ALDRIN Property

Melting point:

104℃

Boiling point:

450.9°C (rough estimate)

Density 

1.6 g/cm³

vapor pressure 

(x 10^-5 mmHg):6.35 and 12 at 20 and 25 °C, respectively (gas saturation-GC, Grayson and Fosbraey, 1982)24.9 at 25 °C (estimated-GC, Bidleman, 1984)

refractive index 

1.5840 (estimate)

Flash point:

-12 °C

storage temp. 

APPROX 4°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

Water Solubility 

0.2mg/L(25 ºC)

Merck 

13,225

BRN 

2336652

Henry's Law Constant

181 at 5 °C, 371 at 15 °C, 427 at 20 °C, 493 at 25 °C, 714 at 35 °C:in 3% NaCl solution: 287 at 5 °C, 566 at 15 °C, 901 at 25 °C, 1,130 at 35 °C (gas stripping-GC, Cetin et al., 2006)

Exposure limits

NIOSH REL: 0.25 mg/m3, IDLH 25 mg/m3; OSHA PEL: TWA 0.25 mg/m3; ACGIH TLV: TWA 0.25 mg/m3.

Stability:

Stable. Non-flammable. Incompatible with active metals, acid oxidizing agents, acid catalysts.

CAS DataBase Reference

309-00-2(CAS DataBase Reference)

IARC

2A (Vol. 5, Sup 7, 117) 2019

EPA Substance Registry System

Aldrin (309-00-2)

Safety

Hazard Codes 

T,N,Xn,F,Xi

Risk Statements 

24/25-40-48/24/25-50/53-67-65-38-11-36-20/21/22-36/37/38-39/23/24/25-23/24/25-52/53-27-25

Safety Statements 

22-36/37-45-60-61-62-36-26-16-33-7-28-29-9

RIDADR 

2761

OEB

C

OEL

TWA: 0.25 mg/m3 [skin]

WGK Germany 

3

RTECS 

IO2100000

HazardClass 

6.1(a)

PackingGroup 

II

Hazardous Substances Data

309-00-2(Hazardous Substances Data)

Toxicity

LD50 in male, female rats (mg/kg): 39, 60 orally (Gaines)

IDLA

25 mg/m3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

ALDRIN Chemical Properties,Usage,Production

Chemical Properties

off-white solid

Physical properties

Colorless to white, odorless crystals when pure; technical grades are tan to dark brown with a mild, characteristic chemical odor. The odor threshold concentration in water is 17 μg/kg (Sigworth, 1964).

Uses

Aldrin has been used as an insecticide for soil insects and the control of termites around buildings. Industrial exposures occur among groups that have been involved in the manufacture of aldrin, and in the handling and spraying of suspensions and emulsions of this compound.

Uses

Insecticide.

Uses

Formerly as insecticide and fumigant; manufacture and use has been discontinued in the U.S

Definition

ChEBI: An organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with norbornadiene. It was widely used as an insecticide before being banned in the 1970s as a persistent organic pollutant.

General Description

Aldrin, cast solid is a brown to white solid. If the large pieces are broken up or powdered, ALDRIN is toxic by inhalation and skin absorption. ALDRIN is insoluble in water and noncombustible. ALDRIN is used as an insecticide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

ALDRIN may be sensitive to prolonged exposure to light. ALDRIN is stable to heat and in the presence of inorganic and organic bases. ALDRIN is stable to hydrated metal chlorides and mild acids. ALDRIN is thermally stable up to 392° F and ALDRIN is stable between pH 4 and 8. ALDRIN reacts with concentrated acids and phenols in the presence of oxidizing agents. ALDRIN can be corrosive to metals. ALDRIN can react with acid catalysts, acid oxidizing agents and active metals.

Hazard

Toxic by skin absorption. Central nervous system impairment, and liver and kidney damage. Questionable carcinogen.

Health Hazard

Highly toxic to humans and animals by allroutes of exposure; absorbed through skin aswell; toxic symptoms — headache, dizziness,nausea, vomiting, tremor, ataxia, convulsions, central nervous system depression, andrespiratory failure; also causes renal damage; oral LD50 value 30–100 mg/kg in mosttest animals metabolizes to dieldrin; oraladministration in rats and mice increased theincidence of liver and lung cancer, carcinogenicity: animal and human evidence inadequate; exposure limit 0.25 mg/m³ (skin)(ACGIH); RCRA Waste Number P004.

Health Hazard

Poisoning by aldrin usually involves convulsions due to its effects on the central nervous system. Reproductive effects and liver effects have also been reported. It is classified as an extremely toxic chemical. Probable oral lethal dose for humans is between 7 drops and one oz. for a 150 lb. adult human. Conflicting reports of carcinogenicity of ALDRIN remain an area of controversy. Similar chemically and toxicologically to dieldrin.

Fire Hazard

When heated to decomposition, ALDRIN emits toxic fumes of chlorine containing compounds. Commercial solutions may contain flammable or combustible liquids. The dry powder will not burn. Container may explode in heat of fire. Avoid concentrated mineral acids, acid catalysts, acid oxidizing agents, phenols, or active metals.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: excitement, tremors, and nausea or vomiting. An experimental teratogen. Other experimental reproductive effects. Continued acute exposure causes liver damage. Human mutation data reported. See also CHLORINATED HYDROCARBONS. When heated to decomposition it emits toxic fumes of Cl-.

Carcinogenicity

Rodent carcinogenicity evaluations of aldrin have been extensively reviewed, with the conclusion that the mouse-specific hepatocarcinogenic activity of aldrin occurs through a nongenotoxic mode of action involving promotion of spontaneously initiated liver cells.

Environmental Fate

Biological. Dieldrin is the major metabolite formed from the microbial degradation of aldrin via epoxidation (Lichtenstein and Schulz, 1959; Korte et al., 1962; Kearney and Kaufman, 1976). Microorganisms responsible for this reaction were identified as Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum and Penicillium notatum (Korte et al., 1962). Dieldrin may further degrade to photodieldrin (Kearney and Kaufman, 1976). A pure culture of the marine alga namely Dunaliella sp. degraded aldrin to dieldrin andthe diol at yields of 23.2 and 5.2%, respectively (Patil et al., 1972). In four successive 7- day incubation periods, aldrin (5 and 10 mg/L) was recalcitrant to degradation in a settled domestic wastewater inoculum (Tabak et al., 1981). In a mixed microbial population under anaerobic conditions, nearly all aldrin (87%) degraded to two unidentified products in 4 days (Maule et al., 1987)
Soil. Patil and Matsumura (1970) reported 13 of 20 soil microorganisms were able to degrade aldrin to dieldrin under laboratory conditions. Harris and Lichtenstein (1961) studied the volatilization of aldrin (4 ppm) in Plainfield sand and quartz
Aldrin was found to be very persistent in an agricultural soil. Fifteen years after application of aldrin (20 lb/acre), 5.8% of the applied dosage was recovered as dieldrin and 0.2% was recovered as photodieldrin (Lichtenstein et al., 1971).
Plant. Photoaldrin and photodieldrin formed when aldrin was codeposited on bean leaves and exposed to sunlight (Ivie and Casida, 1971). Dieldrin and 1,2,3,4,7,8-hexachloro-1,4,4a,6,7,7a-hexahydro-1,4-endo-methyleneindene-5,7-dicarboxylic acid were identified in aldrin-treated soil on which potatoes were grown (Klein et al., 1973)
Surface Water. Under oceanic conditions, aldrin may undergo dihydroxylation at the chlorine free double bond to produce aldrin diol (Verschueren, 1983). When raw water obtained from the Little Miami River in Ohio containing aldrin (10 μg/L) was p

Solubility in organics

50 g/L in alcohol at 25 °C (quoted, Meites, 1963); very soluble (>600 mg/L) in acetone, benzene, xylenes (Worthing and Hance, 1991), and many chlorinated hydrocarbons such as chloroform, carbon tetrachloride, etc.

Solubility in water

50 g/L in alcohol at 25 °C (quoted, Meites, 1963); very soluble (>600 mg/L) in acetone, benzene, xylenes (Worthing and Hance, 1991), and many chlorinated hydrocarbons such as chloroform, carbon tetrachloride, etc.

Toxicity evaluation

Consistent with its intended use on insects in soil, aldrin is not very water soluble. It binds to sediment, but rarely leaches into deeper soil layers and groundwater. Aldrin is volatile and readily degrades to dieldrin in the environment. When aldrin is applied to silty loam soil, the amount detectable in 1.7 years will have declined by 25% of the amount applied. Aldrin is estimated to have a half-life in soil of 1.5–5.2 years, depending on the composition of the soil.
Persistence is defined in terms of the half-life of a substance in the soil. For aldrin, this has been determined to be 2–15 years. Aldrin is largely converted via biological or abiotic mechanisms to dieldrin, which is significantly more persistent. Both aldrin and dieldrin are absorbed into the food chain. Residues may remain in the soil for a long period, if contaminated plant and animal materials are added to the topsoil. Aldrin and dieldrin are retained in the fatty materials of sewage sludge, and in fish emulsions used as fertilizers. Topical soil application of these materials makes these compounds available to grazing animals, which ingest some soil when they crop grass. Aldrin may be volatilized from sediment, and redistributed by air currents, contaminating distant areas. Nationally, levels of aldrin have declined since agricultural uses were discontinued.