Pregnenolone
- Product Name
- Pregnenolone
- CAS No.
- 145-13-1
- Chemical Name
- Pregnenolone
- Synonyms
- prenenolone;5-pregnen-3B-ol-20-one;3β-Hydroxypregn-5-en-20-one;DELTA5-PREGNEN-3BETA-OL-20-ONE;5-Preg;ZK-5553;-20-one;prenolon;pregnolon;nen-3β-oL
- CBNumber
- CB1684326
- Molecular Formula
- C21H32O2
- Formula Weight
- 316.48
- MOL File
- 145-13-1.mol
Pregnenolone Property
- Melting point:
- 188-190 °C
- alpha
- 28.5 º (c=1, EtOH)
- Boiling point:
- 395.89°C (rough estimate)
- Density
- 1.0382 (rough estimate)
- vapor pressure
- 0-0Pa at 20-25℃
- refractive index
- 1.5344 (estimate)
- Flash point:
- 9℃
- storage temp.
- Refrigerator
- solubility
- ethanol: soluble10mg/mL, clear, colorless to faintly yellow
- form
- Powder
- pka
- 15.00±0.70(Predicted)
- color
- White to off-white
- Water Solubility
- 41mg/L(room temperature)
- Merck
- 7733
- BRN
- 2059026
- InChIKey
- ORNBQBCIOKFOEO-QGVNFLHTSA-N
- LogP
- 4.4 at 20℃
- CAS DataBase Reference
- 145-13-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Pregnenolone(145-13-1)
Safety
- Safety Statements
- 22-24/25
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- RTECS
- TU5560700
- HS Code
- 29372900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P9129
- Product name
- 5-Pregnen-3β-ol-20-one
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $31.62
- Updated
- 2024/03/01
- Product number
- P-104
- Product name
- Pregnenolone solution
- Purity
- 100?μg/mL in acetonitrile, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $70.7
- Updated
- 2024/03/01
- Product number
- PHR2564
- Product name
- Pregnenolone
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100MG
- Price
- $583
- Updated
- 2022/05/15
- Product number
- 19864
- Product name
- Pregnenolone
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19864
- Product name
- Pregnenolone
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2024/03/01
Pregnenolone Chemical Properties,Usage,Production
Description
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a number of physiologically active C21 steroids, including the female sex hormone progesterone and the adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19 steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18 female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
Description
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens. Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
Chemical Properties
white to off-white powder
Uses
glucocortcoid, antiinflammatory
Uses
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
Definition
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
General Description
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.
in vitro
pregnenolone is the precursor from which almost all of the other steroid hormones are made, including dhea, testosterone, progesterone, the estrogens and cortisol. pregnenolone also operates as a powerful neurosteroid in the brain, which modulates the transmission of messages from neuron to neuron and strongly influencing learning and memory processes [1].
in vivo
the ability of pregnenolone sulfate derivatives (pregs) to modulate the age-induced learning impairment was tested in 16- month-old mice using the step-down type of passive avoidance. decreased step-down latency was observed in the passive avoidance task in 16-month-old mice compared to 3-month-old mice, revealing retention deficits in old mice. pretraining injections of pregs dose-dependently improved the 24 h delay retention performances in this task in old mice [1].
References
[1] vallée m, mayo w, le moal m. role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. brain res brain res rev. 2001 nov;37(1-3):301-12.
Pregnenolone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pregnenolone manufacturers
- Product
- Pregnenolone 145-13-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 50000KG/month
- Release date
- 2024-04-25
- Product
- Pregnenolone 145-13-1
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2023-10-12
- Product
- Pregnenolone 145-13-1
- Price
- US $90.00-80.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- min99%
- Supply Ability
- 100 tons
- Release date
- 2024-03-20