PREGNENOLONE SULFATE SODIUM SALT
- Product Name
- PREGNENOLONE SULFATE SODIUM SALT
- CAS No.
- 1852-38-6
- Chemical Name
- PREGNENOLONE SULFATE SODIUM SALT
- Synonyms
- Pregnenolone 3-Sulfate;PREGNENOLONE SULFATE SODIUM;Pregnenolone-3-sulfate Sodium;SodiuM Pregnenolone-d4 Sulfate;5-Pregnen-3β-ol-20-one sulfate;Pregnenolone sulphate Na+ salt;Pregnenolone monosulfate sodium;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;Pregnenolone-3-sulfate SodiuM Salt
- CBNumber
- CB8701970
- Molecular Formula
- C21H31NaO5S
- Formula Weight
- 418.52
- MOL File
- 1852-38-6.mol
PREGNENOLONE SULFATE SODIUM SALT Property
- Melting point:
- 192 °C(lit.)
- storage temp.
- Store at -20°C
- solubility
- methanol and water: 1.93 mg/mL
- form
- A crystalline solid
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- P162
- Product name
- Pregnenolone sulfate sodium salt
- Packaging
- 25mg
- Price
- $28.4
- Updated
- 2025/07/31
- Product number
- P162
- Product name
- Pregnenolone sulfate sodium salt
- Packaging
- 100mg
- Price
- $82.74
- Updated
- 2025/07/31
- Product number
- 21004
- Product name
- Pregnenolone sulfate (sodium salt)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 21004
- Product name
- Pregnenolone sulfate (sodium salt)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $80
- Updated
- 2024/03/01
- Product number
- 21004
- Product name
- Pregnenolone sulfate (sodium salt)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $163
- Updated
- 2024/03/01
PREGNENOLONE SULFATE SODIUM SALT Chemical Properties,Usage,Production
Description
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
Uses
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).
Uses
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
in vivo
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
IC 50
CB1; Human Endogenous Metabolite
storage
Store at +4°C
References
[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237
PREGNENOLONE SULFATE SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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