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Trenbolone

Product Name
Trenbolone
CAS No.
10161-33-8
Chemical Name
Trenbolone
Synonyms
17β-Trenbolone;17β-Trenbolone;Parabola;Trenbolone enthanate;trenbolon;BETA-TRENBOLONE;R 2580;ru2341;Tren 100;TRENBOLONE
CBNumber
CB4459901
Molecular Formula
C18H22O2
Formula Weight
270.37
MOL File
10161-33-8.mol
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Trenbolone Property

Melting point:
170°C
alpha 
D20 +19° (c = 0.45 in ethanol)
Boiling point:
490.8±45.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
Flash point:
2℃
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
pka
14.73±0.40(Predicted)
InChI
InChI=1/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/s3
InChIKey
MEHHPFQKXOUFFV-OWSLCNJRSA-N
SMILES
[C@@]12([H])CC[C@H](O)[C@@]1(C)C=CC1=C3CCC(=O)C=C3CC[C@@]21[H] |&1:0,4,6,20,r|
CAS DataBase Reference
10161-33-8(CAS DataBase Reference)
EPA Substance Registry System
Estra-4,9,11-trien-3-one, 17-hydroxy-, (17.beta)- (10161-33-8)
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Safety

Hazard Codes 
T,Xn,F
Risk Statements 
60-36-20/21/22-11
Safety Statements 
53-22-36/37/39-45-36/37-26-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
KG7752000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3925
Product name
Trenbolone
Purity
analytical standard, for drug analysis
Packaging
1g
Price
$490
Updated
2024/03/01
Sigma-Aldrich
Product number
T-043
Product name
Trenbolone solution
Purity
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$125
Updated
2024/03/01
Cayman Chemical
Product number
16896
Product name
Trenbolone
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16896
Product name
Trenbolone
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
T3925
Product name
Trenbolone
Purity
analytical standard, for drug analysis
Packaging
250mg
Price
$159
Updated
2024/03/01
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Trenbolone Chemical Properties,Usage,Production

Description

Trenbolone, also known as trienolone or trienbolone, is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency.

Chemical Properties

Yellow Solid

Originator

Parabolan,Negma,France,1980

Uses

Trenbolone is a controlled substance (anabolic steroid). It is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.

Preparation

Trenbolone synthesis: To a cold mixture of 47.9 g 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in 375 mL anhydrous methylene chloride (DCM), a solution of 54.9 g compound (II-a) and 11.5 mL acetic acid in 150 mL anhydrous DCM is added dropwise under stirring, while keeping the internal temperature at -5 °C. The addition funnel is rinsed with 25 mL DCM and this aliquot is added to the reaction mixture. After 4 hours, reaction conversion reaches 99.25% by HPLC. The reaction mixture is quenched by addition of a solution composed of 5.7 g of Na2S2O5, 50 mL water and 10 mL MeOH. The obtained slurry is warmed to 15-23°C and left stirring for 0.5 h, after which it was filtered. The filter cake is washed with 2x40 mL DCM and the solid discarded. The obtained biphasic mixture is separated, and the organic phase washed twice with a solution of 100 mL water, 10 mL MeOH and 3.9 g of NaHCO3. The phases are separated, and the organic layer washed one final time with a solution of 100 mL water, 10 mL MeOH and 3.9 g of NaHCO3. The combined solution is concentrated with stirring to 150 mL (total volume) under vacuum, keeping the internal temperature below 30 °C. To the resulting solution, 150 mL of acetone are added, and the obtained mixture concentrated under vacuum to 150 mL (total volume) again, keeping the internal temperature below 30 °C. This addition/concentration protocol is repeated 3 times. The resulting suspension is cooled to 0 °C and kept at this temperature for 0.5 h with stirring, after which it is filtered, and the filter cake is washed twice with 50 mL cold acetone. The wet solid is dried at 40 °C under vacuum to give Trenbolone in 76% yield and 98.2 % A/A purity by HPLC.

Synthesis of Trenbolone acetate

Definition

ChEBI: Trenbolone is a 3-oxo-Delta(4) steroid that is estra-4,9,11-triene carrying an oxo group at position 3 and a hydroxy group at position 17beta. It is a synthetic anabolic steroid used for muscle growth in livestock. It has a role as a plant metabolite and an endocrine disruptor. It is a 3-oxo-Delta(4) steroid, a 17beta-hydroxy steroid, a C18-steroid and an anabolic androgenic steroid.

brand name

[Trenbolone is INN and BAN.

Therapeutic Function

Anabolic steroid

Side effects

Trenbolone's side effects aren't only physical but also mental, with users commonly reporting feeling increasingly: irritable, anxious, paranoid and depressed (than on other steroids).
Such side effects can be linked to Trenbolone having a stimulating effect on the central nervous system, causing an increase in adrenaline output and thus shifting Tren-users into a state of fight or flight mode.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

References

https://en.wikipedia.org/wiki/Trenbolone
https://www.steroid.com/Trenbolone.php
Škorjanc, D, M. Brus, and I. Vojtic. "A short review of chain controlling systems in livestock production technology. " Agricultura (2005).

Trenbolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Trenbolone Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4554
Advantage
62
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
977
Advantage
58
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
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View Lastest Price from Trenbolone manufacturers

CONTIDE BIOTECH CO.,LTD
Product
Trenbolone Enanthate (parabolan) 10161-33-8
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-03-27
Hebei Miaoyin Technology Co.,Ltd
Product
Trenbolone 10161-33-8
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000
Release date
2023-04-14
.GZ HONESTCHEM CO.,LTD
Product
Trenbolone 10161-33-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
500KG
Release date
2018-09-14

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