Description Application Uses Biological Activity Interactions in vitro
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Altrenogest

Description Application Uses Biological Activity Interactions in vitro
Product Name
Altrenogest
CAS No.
850-52-2
Chemical Name
Altrenogest
Synonyms
11-trien-3-one,17-alpha-allyl-17-hydroxy-estra-9;Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propenyl)-, (17b)-;r2267;D02840;ru2267;A 35957;drc6246;REGUMATE;ltrenogest;Altrenoges
CBNumber
CB7211951
Molecular Formula
C21H26O2
Formula Weight
310.44
MOL File
850-52-2.mol
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Altrenogest Property

Melting point:
120°
alpha 
D20 -72° (c = 0.5 in ethanol)
Boiling point:
390.58°C (rough estimate)
Density 
1.0865 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
pka
14.59±0.40(Predicted)
color 
White to Yellow
Merck 
14,319
InChI
InChI=1/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/s3
InChIKey
VWAUPFMBXBWEQY-ANULTFPQSA-N
SMILES
C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC=C |&1:1,14,16,20,r|
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Safety

WGK Germany 
3
RTECS 
KG7745000
HS Code 
2937.23.5050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33994
Product name
Altrenogest
Purity
VETRANAL?, analytical standard
Packaging
100MG
Price
$119
Updated
2024/03/01
TCI Chemical
Product number
A2892
Product name
Altrenogest
Purity
>98.0%(HPLC)
Packaging
200mg
Price
$63
Updated
2024/03/01
TCI Chemical
Product number
A2892
Product name
Altrenogest
Purity
>98.0%(HPLC)
Packaging
1g
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
27218
Product name
Altrenogest
Packaging
250mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
27218
Product name
Altrenogest
Packaging
500mg
Price
$116
Updated
2024/03/01
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Altrenogest Chemical Properties,Usage,Production

Description

Altrenogest is used to suppress estrus in mares in order to facilitate induction of normal estrous cycle activity. It is also used in mares to synchronize scheduled breeding activity. In the suppression of estrous behavior in mares, this is usually related to mares that are used as performance horses.

Application

Altrenogest is a progestin of the 19-nortestosterone group. As a veterinary medication, it is used extensively in the reproductive management of mares to control the reproductive cycle, help maintain pregnancy, and help with behavior modification. Altrenogest has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to subtherapeutic progestin levels. Altrenogest is typically administered orally by applying directly on the base of the mare’s tongue or on the mare’s feed.

Uses

Altrenogest is used for suppression of estrus. The mare will experience a predictable occurrence of estrus following drug withdrawal. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. By managing the reproductive cycle, horse owners have more control over breeding procedures and the timing of the arrival of foals.

Biological Activity

Altrenogest suspension by NexGen is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced.

Interactions

Rifampin may increase the speed of metabolism of Regu-Mate.

in vitro

Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with Altrenogest (Allyltrenbolone) appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. The oil and gel Altrenogest (Allyltrenbolone) preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest (Allyltrenbolone) treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL.

Chemical Properties

Pale Yellow Solid

Uses

Altrenogest can be used as a synthetic progestational agent used in veterinary medicine for the control of estrus in mares and antineoplastic.

Definition

ChEBI: Altrenogest is a 3-hydroxy steroid.

brand name

REGUMATE (Roussel-UCLAF, France).

Side effects

People exposed to altrenogest products have potential health risks. Reproductive adverse effects reported in women and girls include abnormal or absent menstrual cycles, and in men include decreased libido. Other adverse effects reported after exposure include headaches, fever, abdominal pain, nausea, diarrhea, vomiting, and rashes.
Altrenogest causes essentially no side effects in mares, and it may be used for prolonged periods.

Veterinary Drugs and Treatments

Altrenogest (Regu-Mate) is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. Some authors (Squires et al. 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered excellent candidates for progestin treatment.
Altrenogest is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. Estrus will ensue 2 – 5 days after treatment is completed and most mares ovulate between 8 – 15 days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to sub-therapeutic progestin levels.
The product Matrix is labeled for synchronization of estrus in sexually mature gilts that have had at least one estrous cycle. Treatment with altrenogest results in estrus (standing heat) 4-9 days after completion of the 14-day treatment period.
Altrenogest has been used in dogs for luteal insufficiency and as a treatment to prevent premature delivery.

Altrenogest Preparation Products And Raw materials

Raw materials

Preparation Products

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Altrenogest Suppliers

Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@qq.com
Country
China
ProdList
1890
Advantage
58
CHENGHUI PHARMACEUTICAL GROUP LTD
Tel
0531-58897070 15254140813
Fax
0531-58897046
Email
market@jnchsd.com
Country
China
ProdList
208
Advantage
58
Shanghai Jinli Pharmaceutical Co.,Ltd.
Tel
+86-021-57256005 +86-15921811235
Email
chang@shjlchem.com
Country
China
ProdList
9
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17839
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
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View Lastest Price from Altrenogest manufacturers

Hebei Kangcang new material Technology Co., LTD
Product
Altrenogest 850-52-2
Price
US $11.00-90.00/kg
Min. Order
0.10000000149011612kg
Purity
99%
Supply Ability
10 tons
Release date
2024-03-20
PNP Biotech Co. Ltd
Product
Altrenogest 850-52-2
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2022-10-19
Shanghai Aosiris new Material Technology Co., LTD
Product
Altrenogest 850-52-2
Price
US $3.00-1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10 tons
Release date
2024-03-27

850-52-2, AltrenogestRelated Search:


  • 11-trien-3-one,17-alpha-allyl-17-hydroxy-estra-9
  • 17-allyltrenbolone
  • 17-alpha-allyl-estratriene-4,9,11,17-beta-ol-3-one
  • 17-hydroxy-17-(2-propenyl)-(17-beta)-estra-11-trien-3-one
  • D02840
  • ALLYLTRENBOLONE
  • ALTRENOGEST
  • 17-ALPHA-ALLYL-17-BETA-HYDROXYOESTRA-4,9,11-TRIEN-3-ONE
  • REGUMATE
  • 17-α-Allyl-17-β-hydroxyoestra-4,9,11-trien-3-one, Allyltrenbolone, Regumate
  • 17a-Allyl-estratriene-4,9,11,17b-ol-3-one
  • Estra-4,9,11-trien-3-one, 17a-allyl-17-hydroxy-
  • Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propenyl)-, (17b)-
  • 17α-Allyl-17-hydroxy-estra-4,9,11-trien-3-one
  • Altrenogest (usan/inn)
  • Allyltrienolone
  • Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propenyl)-, (17.beta.)-
  • 17-α-allyl-17-β-hydroxyoestra-4,9,11-trien-3-one
  • Altrenogest, Vetranal
  • (8S,13S,14S,17R)-17-hydroxy-13-methyl-17-prop-2-enyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • 14-hydroxy-15-Methyl-14-(prop-2-en-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6,16-trien-5-one
  • (17β)-17-Hydroxy-17-(2-propen-1-yl)estra-4,9,11-trien-3-one
  • (17β)-17-Hydroxy-17-(2-propenyl)estra-4,9,11-trien-3-one
  • A 35957
  • Altrenogest 0
  • (8S,13S,14S,17R)-17-allyl-17-hydroxy-13-methyl-1,2,7,8,13,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3(14H)-one
  • Altrenogest Intermediate
  • drc6246
  • r2267
  • ru2267
  • Natural Altrenogest
  • Altrenogest Standard
  • Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propen-1-yl)-, (17β)-
  • (8S,13S,14S,17S)-17-Allyl-17-hydroxy-13-methyl-6,7,8,13,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • 17-alpha-Allyl-17-beta-hydroxyestra-4,9,11-trien-3-one
  • Progesterone Altrenogest
  • Steroids Altreniogest
  • Allyl progesterone / tetraestrone
  • ltrenogest
  • Altrenogest (Allyltrenbolone
  • (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline,hydrochloride
  • Four xi estrone
  • Altrenoges
  • Allyl progesterone*
  • 4, 9, 11-ESTRATRIEN-17α-ALLYL-17β-OL-3-ONE
  • 850-52-2
  • 850-52-5
  • C21O29
  • FLUDARA
  • Hormone
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Steroid and Hormone
  • 850-52-2
  • API