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Allylestrenol

Product Name
Allylestrenol
CAS No.
432-60-0
Chemical Name
Allylestrenol
Synonyms
organon;Turinal;gestanin;gestanol;gestanon;gestanyn;orageston;NSC 37723;ALLYLESTRENOL;allyl-estreno
CBNumber
CB7739529
Molecular Formula
C21H32O
Formula Weight
300.48
MOL File
432-60-0.mol
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Allylestrenol Property

Melting point:
79.5-80°
Boiling point:
381.7°C (rough estimate)
Density 
0.9914 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
14.95±0.40(Predicted)
form 
Solid
color 
White to Pale Yellow
Merck 
14,291
CAS DataBase Reference
432-60-0(CAS DataBase Reference)
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Safety

RTECS 
KG7960000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A554755
Product name
Allylestrenol
Packaging
100mg
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
28191
Product name
Allylestrenol,97-102%(assay)
Purity
97-102%(assay)
Packaging
250MG
Price
$44.8
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55289
Product name
Allylestrenol
Packaging
500mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
28191
Product name
Allylestrenol,97-102%(assay)
Purity
97-102%(assay)
Packaging
1G
Price
$93.18
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55289
Product name
Allylestrenol
Packaging
1g
Price
$143.8
Updated
2021/12/16
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Allylestrenol Chemical Properties,Usage,Production

Originator

Alilestrenol ,Terapia

Uses

A synthetic steroid with progestational activity.

Uses

Allylestrenol, is a synthetic sexualsteroid, that is used worldwide in case of endangered pregnancies.

Definition

ChEBI: Allylestrenol is a steroid. It derives from a hydride of an estrane.

Manufacturing Process

To 145 ml of dry methylamine which is cooled to -20°C 1.5 g of lithium cut to small pieces are added. To the solution which is blue in color after 10-20 min, a solution of 3.0 g of oestradiol-3-methylether in 145 ml of absolute ether is added drop wise. Subsequently the reaction mixture is stirred at -10°C for 40 h, after which 50 ml of absolute ethanol are added. Then the methylamine is distilled off at law pressure.
To the remaining solution 50 ml of ether and 50 ml of water are added. The water layer is separated and extracted with ether. The ethereal layer is washed with a 2 N hydrochloric acid solution, subsequently with a saturated sodium bicarbonate solution, and then with water. The ethereal solution is dried and evaporated to dryness. The resulting crude reaction product is dissolved in a mixture of benzene and petroleum ether (1:3) and chromatographed over aluminium oxide. The δ4-17β-hydroxy-oestrene obtained after chromatographic purification has a melting point of 80°-90°C and 95°-100°C after repeated crystallization from petroleum ether.
A solution of 13.2 g of chromium trioxide in a mixture of 120 ml of water and 20 ml of acetic acid is added, with stirring, to a solution of 20 g of δ4-17β- hydroxy-oestrene in 400 ml of benzene. Subsequently the reaction mixture is vigorously stirred at room temperature for 16 h, after which the benzene layer is separated.
The remaining aqueous layer is extracted a few times with benzene and the benzene extracts collected are then added to the separated benzene layer. The benzene extracts are successively washed with dilute sulfuric acid and water and then evaporated to dryness. The residue is crystallized from acetone, and the δ4-17β-oxo-oestrene, melting point 114°-116°C is obtained. To a mixture of 22.4 ml of absolute ether and 1.84 g of magnesium, a mixture of 2.72 ml of allyl bromide and 2.72 ml of absolute ether is added in nitrogen atmosphere. Subsequently a solution of 2 g of δ4-17β-oxo-oestrene in 30 ml of absolute ether is added to this reaction mixture, after which the whole is stirred for 4 h. Then the reaction mixture is poured into acidified ice water. The aqueous mixture is extracted with ether; the ether layer is separated, washed with water, dried over sodium sulfate and evaporated to dryness. The residue is recrystallized from a mixture of ether and petroleum ether, giving δ4-17β-hydroxy-17α-allyl-oestrene, melting point 79.5°-80°C.

Therapeutic Function

Progestin; Antiandrogen

Allylestrenol Preparation Products And Raw materials

Raw materials

Preparation Products

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Allylestrenol Suppliers

Changzhou Siyao Pharmaceuticals Co., Ltd
Tel
0519-88813110
Fax
0519-88825678
Email
siyao@czsiyao-pharm.com
Country
China
ProdList
26
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from Allylestrenol manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Allylestrenol 432-60-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-13
Wuhan Haorong Biotechnology Co.,Ltd
Product
Allylestrenol 432-60-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27
Wuhan Cell Pharmaceutical Co., Ltd
Product
Allylestrenol 432-60-0
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-05-17

432-60-0, AllylestrenolRelated Search:


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  • 17-allylestr-4-en-17-beta-ol
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  • 17-alpha-allyl-3-deoxy-19-nortestosterone
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  • 17-alpha-allyl-4-oestrene-17-beta-ol
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  • 21-methylene-19-nor-17-alpha-preg-4-en-17-o
  • 21-methylene-19-nor-17-alpha-preg-4-en-17-ol
  • ALLYLESTRENOL
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  • Estr-4-en-17b-ol, 17-allyl- (6CI, 8CI)
  • Estr-4-en-17-ol, 17-(2-propenyl)-, (17β)-
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  • 3-deoxy-17-alpha-allyl-19-nortestosterone
  • allyl-estreno
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