Gestrinone

Product Name: Gestrinone
CAS No.: 16320-04-0
Chemical Name: Gestrinone
Synonyms: ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
CBNumber: CB3121391
Molecular Formula: C21H24O2
Formula Weight: 308.41
MOL File: 16320-04-0.mol

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Gestrinone Property

Melting point:: 150-152°C
alpha: D20 +84.6° (c = 0.41 in methanol)
Boiling point:: 388.8°C (rough estimate)
Density: 1.1040 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: -20°C Freezer
solubility: DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM)
form: A crystalline solid
pka: 12.76±0.40(Predicted)
color: Off-white to light yellow
Merck: 14,4415
Stability:: Hygroscopic
InChI: InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1
InChIKey: BJJXHLWLUDYTGC-ANULTFPQSA-N
SMILES: C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1
CAS DataBase Reference: 16320-04-0(CAS DataBase Reference)

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Safety

RTECS: JF7964000
Toxicity: mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Purity: ≥98%
Packaging: 100mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Purity: ≥98%
Packaging: 500mg
Price: $459
Updated: 2024/03/01

Cayman Chemical

Product number: 10006488
Product name: Gestrinone
Packaging: 1000mg
Price: $864
Updated: 2024/03/01

Chem-Impex

Product number: 37917
Product name: Gestrinone,≥98%(AssaybyTitration)
Purity: ≥98%(AssaybyTitration)
Packaging: 100MG
Price: $292.36
Updated: 2021/12/16

AvaChem

Product number: 3789
Product name: Gestrinone
Packaging: 5mg
Price: $129
Updated: 2021/12/16

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Gestrinone Chemical Properties,Usage,Production

Description

Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.

Chemical Properties

Light Yellow Solid

Originator

Roussel UCLAF (France)

Uses

Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.

Definition

ChEBI: Gestrinone is an oxo steroid.

brand name

DIMETROSE

Side effects

Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.

Mode of action

The primary action of gestrinone is on the hypothalamic-pituitary axis, where it inhibits gonadotrophin release with a weak inhibitory effect on its synthesis. It also possesses anti-estrogen activity. The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibiting ovulation[1].

References

[1] Xuefeng Gao, Guian Chen, Erruo Wu . “Mechanism of emergency contraception with gestrinone: a preliminary investigation.” Contraception 76 3 (2007): Pages 221-227.

Gestrinone Preparation Products And Raw materials

Raw materials

2-N-BUTOXYETHYL METHACRYLATE Nitrogen Grignard reagent Cyclohexane Pyruvic acid Acetylacetone Double ring Estradiene dione-3-keta Magnesium silicate Pyrrolidine

Preparation Products

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Gestrinone Suppliers

Americas 1 Canada 1 China 84 Europe 1 India 2 Japan 1 United Kingdom 5 United States 8 Global 103

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

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View Lastest Price from Gestrinone manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Gestrinone 16320-04-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-02-10

Nantong Guangyuan Chemicl Co,Ltd

Product: Gestrinone 16320-04-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Gestrinone 16320-04-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

16320-04-0, GestrinoneRelated Search:

Ethyl acrylate Ethyl formate Ethyl pyruvate ISOXADIFEN-ETHYL Ethyl acetate Ethylparaben Ethanol CHLOROPHOSPHONAZO III Pregnenolone Leuprorelin Mifepristone Trenbolone Progesterone 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Gestodene (Z)-Guggulsterone Eltanolone GUGGULSTERONE E

(8s,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGNA-4,9,11-TRIEN-20-YN-3-ONE

D-GESTRINONE

GESTRINONE

9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-19-dinorpregna-(17-alpha)-1

ethylnorgestrienone

gestrigone

r-2323

ru2323

CAS16320-04-0 Gestrinone 99%min Dimetriose

Gestrinone 99%min Dimetriose

13-beta-ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one

13-ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one

13-Ethyl-17α-ethynyl-17-hydroxy-4，9，11-gonatrien-3-one

A-46745

Dimetriose

Dimetrose

Nemestran：Tridomose

(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

13-Ethyl-17α-ethynyl-17β-hydroxygona-4,9,11-trien-3-one

NeMestran

TridoMose

Gestrinone (8S,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one

19-dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,13-ethyl-17-hydroxy-1

13-Ethyl-17-alpha-ethynyl-17-hydroxygon-4,9,11-trien-3-one

Gestrinone (1.0mg/ml in Acetonitrile)

18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-

Gestrinone USP/EP/BP

4, 9, 11-ESTRATRIEN-17α-ETHYLNY-18-HOMO-17β-OL-3-ONE

gestinone.

16320-04-0

C21H24O2

Hormone

Active Pharmaceutical Ingredients

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids