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Progabide

Product Name
Progabide
CAS No.
62666-20-0
Chemical Name
Progabide
Synonyms
Gabren;Gabrene;SL-76.002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
CBNumber
CB1296044
Molecular Formula
C17H16ClFN2O2
Formula Weight
334.77
MOL File
62666-20-0.mol
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Progabide Property

Melting point:
133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Boiling point:
525.4±50.0 °C(Predicted)
Density 
1.2822 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
form 
Solid
pka
pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
color 
Light Yellow to Yellow
Water Solubility 
37.16mg/L(37 ºC)
CAS DataBase Reference
62666-20-0
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Safety

Toxicity
LD50 i.p. in mice: 900 mg/kg (Kaplan)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P755350
Product name
Progabide
Packaging
100mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP103146
Product name
Progabide
Packaging
50mg
Price
$200
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48387
Product name
Progabide
Packaging
100mg
Price
$650
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009296
Product name
PROGABIDE
Purity
95.00%
Packaging
100MG
Price
$750.75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP103146
Product name
Progabide
Packaging
10mg
Price
$80
Updated
2021/12/16
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Progabide Chemical Properties,Usage,Production

Description

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

Chemical Properties

Bright Yellow Solid

Originator

Synthelabo (France)

Uses

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

Definition

ChEBI: Progabide is a diarylmethane.

brand name

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

Progabide Preparation Products And Raw materials

Raw materials

Preparation Products

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Progabide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7266
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9355
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
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View Lastest Price from Progabide manufacturers

Dideu Industries Group Limited
Product
Progabide 62666-20-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22

62666-20-0, ProgabideRelated Search:


  • progabide
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  • Halogabide
  • (E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
  • 4-[[(Z)-(4-Chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide
  • 4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide
  • C-abren(e)
  • SL-76.002
  • 4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide
  • Gabren
  • Gabrene
  • Progabide USP/EP/BP
  • 62666-20-0
  • C17H16ClFN2O2
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals