Progabide
- Product Name
- Progabide
- CAS No.
- 62666-20-0
- Chemical Name
- Progabide
- Synonyms
- Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
- CBNumber
- CB1296044
- Molecular Formula
- C17H16ClFN2O2
- Formula Weight
- 334.77
- MOL File
- 62666-20-0.mol
Progabide Property
- Melting point:
- 133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
- Boiling point:
- 525.4±50.0 °C(Predicted)
- Density
- 1.2822 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
- color
- Light Yellow to Yellow
- Water Solubility
- 37.16mg/L(37 ºC)
- CAS DataBase Reference
- 62666-20-0
Safety
- Toxicity
- LD50 i.p. in mice: 900 mg/kg (Kaplan)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P755350
- Product name
- Progabide
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FP103146
- Product name
- Progabide
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 48387
- Product name
- Progabide
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- API0009296
- Product name
- PROGABIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- FP103146
- Product name
- Progabide
- Packaging
- 10mg
- Price
- $80
- Updated
- 2021/12/16
Progabide Chemical Properties,Usage,Production
Description
Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.
Chemical Properties
Bright Yellow Solid
Originator
Synthelabo (France)
Uses
Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.
Definition
ChEBI: Progabide is a diarylmethane.
brand name
Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.
World Health Organization (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.
Progabide Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Progabide manufacturers
- Product
- Progabide 62666-20-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-22