Progabide

Product Name: Progabide
CAS No.: 62666-20-0
Chemical Name: Progabide
Synonyms: Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
CBNumber: CB1296044
Molecular Formula: C17H16ClFN2O2
Formula Weight: 334.77
MOL File: 62666-20-0.mol

More

Less

Progabide Property

Melting point:: 133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Boiling point:: 525.4±50.0 °C(Predicted)
Density: 1.2822 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
form: Solid
pka: pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
color: Light Yellow to Yellow
Water Solubility: 37.16mg/L(37 ºC)
CAS DataBase Reference: 62666-20-0

More

Less

Safety

Toxicity: LD50 i.p. in mice: 900 mg/kg (Kaplan)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: P755350
Product name: Progabide
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP103146
Product name: Progabide
Packaging: 50mg
Price: $200
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48387
Product name: Progabide
Packaging: 100mg
Price: $650
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009296
Product name: PROGABIDE
Purity: 95.00%
Packaging: 100MG
Price: $750.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP103146
Product name: Progabide
Packaging: 10mg
Price: $80
Updated: 2021/12/16

More

Less

Progabide Chemical Properties,Usage,Production

Description

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

Chemical Properties

Bright Yellow Solid

Originator

Synthelabo (France)

Uses

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

Definition

ChEBI: Progabide is a diarylmethane.

brand name

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

Progabide Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Butyric Acid Cyclohexane Chloroform Tetrahydrofuran Sodium bicarbonate Magnesium sulfate

Preparation Products

More

Less

Progabide Suppliers

Canada 1 China 37 Europe 2 India 1 United States 8 USA 1 Global 50

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15085
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3238
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29016
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24131
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9799
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4030
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 4257
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29989
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5019
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-61856358 15829046862
Email: 1035@dideu.com
Country: China
ProdList: 10011
Advantage: 58

RD International Technology Co., Limited

Tel: 18988968278
Email: sales@ubiochem.com
Country: China
ProdList: 9146
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32480
Advantage: 60

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6805
Advantage: 58

Shanghai Yubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 344843571@qq.com
Country: CHINA
ProdList: 6322
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6192
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6979
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6011
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6942
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6005
Advantage: 58

Ningbo Pangs Chem Int'l Co., Ltd.

Tel: --
Fax: --
Email: zjuxiaoling@gmail.com
Country: China
ProdList: 269
Advantage: 50

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: --
Fax: --
Email: sales@rovathin.com
Country: China
ProdList: 4396
Advantage: 58

More

Less

View Lastest Price from Progabide manufacturers

Dideu Industries Group Limited

Product: Progabide 62666-20-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-22

62666-20-0, ProgabideRelated Search:

FLORASULAM Propafenone Methylparaben Thiophanate-methyl Bensulfuron methyl Flutamide 2-Aminocyclohexanol Cyclamic acid p-Aminobenzamide Sulfluramid Flumetralin Tiopronin FLUMIOXAZIN Molasses Kresoxim-methyl Methyl acrylate 3-Aminobenzenesulfonamide Sulfanilamide

progabide

BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-

Halogabide

(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide

4-[[(Z)-(4-Chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide

4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide

C-abren(e)

SL-76．002

4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide

Gabren

Gabrene

Progabide USP/EP/BP

62666-20-0

C17H16ClFN2O2

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals