ChemicalBook > CAS DataBase List > Progabide

Progabide

Product Name
Progabide
CAS No.
62666-20-0
Chemical Name
Progabide
Synonyms
Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;Progabide, 10 mM in DMSO;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide
CBNumber
CB1296044
Molecular Formula
C17H16ClFN2O2
Formula Weight
334.77
MOL File
62666-20-0.mol
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Progabide Property

Melting point:
133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
Boiling point:
525.4±50.0 °C(Predicted)
Density 
1.2822 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
form 
Solid
pka
pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
color 
Light Yellow to Yellow
Water Solubility 
37.16mg/L(37 ºC)
CAS DataBase Reference
62666-20-0
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Safety

Toxicity
LD50 i.p. in mice: 900 mg/kg (Kaplan)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P755350
Product name
Progabide
Packaging
100mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP103146
Product name
Progabide
Packaging
50mg
Price
$200
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48387
Product name
Progabide
Packaging
100mg
Price
$650
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009296
Product name
PROGABIDE
Purity
95.00%
Packaging
100MG
Price
$750.75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP103146
Product name
Progabide
Packaging
10mg
Price
$80
Updated
2021/12/16
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Progabide Chemical Properties,Usage,Production

Description

Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.

Chemical Properties

Bright Yellow Solid

Originator

Synthelabo (France)

Uses

Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.

Definition

ChEBI: Progabide is a diarylmethane.

brand name

Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.

World Health Organization (WHO)

Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.

Progabide Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Butyric Acid Cyclohexane Chloroform Tetrahydrofuran Sodium bicarbonate Magnesium sulfate

Preparation Products

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Progabide Suppliers

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View Lastest Price from Progabide manufacturers

Dideu Industries Group Limited
Product
Progabide 62666-20-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22

62666-20-0, ProgabideRelated Search:

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  • progabide
  • BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-
  • Halogabide
  • (E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
  • 4-[[(Z)-(4-Chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide
  • 4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide
  • C-abren(e)
  • SL-76．002
  • 4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide
  • Gabren
  • Gabrene
  • Progabide USP/EP/BP
  • Progabide, 10 mM in DMSO
  • 62666-20-0
  • C17H16ClFN2O2
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals