Boc-Aib-OH

Product Name: Boc-Aib-OH
CAS No.: 30992-29-1
Chemical Name: Boc-Aib-OH
Synonyms: 2-((tert-butoxycarbonyl)aMino)-2-Methylpropanoic acid;BOC-Aib;N-BOC-2-AMINOISOBUTYRIC ACID;2-(Boc-Amino)Isobutyric Acid;N-Boc-2-aMino-2-Methylpropanoic acid;ANAM-001;tert Acid;BOC-AIB-OH;N-ALPHA-T-B;Boc-L-Aib-OH
CBNumber: CB0133216
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 30992-29-1.mol

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Boc-Aib-OH Property

Melting point:: 118-122 °C
Boiling point:: 341.54°C (rough estimate)
Density: 1.1886 (rough estimate)
refractive index: 1.4315 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Crystalline Powder
pka: 4.11±0.10(Predicted)
color: White
BRN: 1953772
InChI: InChI=1S/C9H17NO4/c1-8(2,3)14-7(13)10-9(4,5)6(11)12/h1-5H3,(H,10,13)(H,11,12)
InChIKey: VLHQXRIIQSTJCQ-LURJTMIESA-N
SMILES: C(O)(=O)[C@](C)(C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 30992-29-1(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53077
Product name: Boc-Aib-OH
Purity: Novabiochem?
Packaging: 25g
Price: $226
Updated: 2025/07/31

TCI Chemical

Product number: B3323
Product name: 2-(tert-Butoxycarbonylamino)isobutyric Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: B3323
Product name: 2-(tert-Butoxycarbonylamino)isobutyric Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $76
Updated: 2025/07/31

TRC

Product number: B656940
Product name: Boc-α-Methylalanine
Packaging: 50g
Price: $305
Updated: 2021/12/16

TRC

Product number: B656940
Product name: Boc-α-Methylalanine
Packaging: 10g
Price: $120
Updated: 2021/12/16

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Boc-Aib-OH Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Boc-α-Methylalanine is used as a catalyst in the preparation of 2-benzopyranone derivatives (isocoumarin) as well as arylbenzeneacetic acids.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

62-57-7

30992-29-1

The general procedure for the synthesis of 2-((tert-butoxycarbonyl)amino)-2-methylpropionic acid from di-tert-butyl dicarbonate and 2-aminoisobutyric acid is as follows: Preparation of Example 26: 2-(tert-butoxycarbonylamino)-2-methylpropionic acid 200 mg (1.94 mmol) of 2-amino-2-methylpropionic acid was dissolved in a solvent mixture of 8.0 mL of 1.0 N NaOH solution and 8.0 mL of 1,4-dioxane, followed by the addition of 846 mg (3.88 mmol) of di-tert-butyl dicarbonate (Boc2O). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, 1,4-dioxane was removed by distillation under reduced pressure. The residue was adjusted to pH 3 with 1N HCl solution and then extracted with 320 mL of ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 315 mg of the white solid product 2-(tert-butoxycarbonylamino)-2-methylpropanoic acid in 80% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 5.07 (brs, 1H), 1.54 (s, 6H), 1.45 (s, 9H).

References

[1] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 4, p. 1391 - 1397
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 20, p. 5679 - 5683
[3] Angew. Chem., 2018, vol. 130, p. 5781 - 5785,5
[4] Patent: US2015/210635, 2015, A1. Location in patent: Paragraph 0502-0504
[5] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0118; 0119

Boc-Aib-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Aib-OH Suppliers

Americas 1 Belgium 1 Canada 2 China 280 Europe 2 France 1 Germany 6 India 5 Japan 4 South Korea 1 Switzerland 2 United Kingdom 6 United States 26 Global 337

Taizhou Tianhong Biochemistry Technology Co., Ltd.

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Alfa Aesar

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Sichuan Tongsheng Amino acids Co.,Ltd.

Tel: 0838-2274206 13908101207
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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from Boc-Aib-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Aib-OH 30992-29-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-alpha-Methylalanine 30992-29-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-(tert-Butoxycarbonylamino)isobutyric Acid 30992-29-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

30992-29-1, Boc-Aib-OHRelated Search:

PENICILLIN V 3-Aminophenol Methyl acrylate ALTRENOGEST Isobutyric acid 2-(4-Chlorophenoxy)-2-methylpropionic acid EC 2.6.1.2 Dimethyl 2,2'-azobis(2-methylpropionate) Bensulfuron methyl Phenprobamate D-Alanine CARBONYL SULFIDE Glycine Kresoxim-methyl Diethylstilbestrol 6-Aminocaproic acid Tris(hydroxymethyl)aminomethane α-Lipoic Acid

RARECHEM EM WB 0052

BOC-alpha-Methylalanine,98%

N-BOC-2-AMINOISOBUTYRIC ACID

N-ALPHA-T-BUTOXYCARBONYL-ALPHA-AMINOISOBUTYRIC ACID

2-Methyl-2-(tert-butoxycarbonylamino)propionic acid

N-(tert-Butoxycarbonyl)-2-methylalanine

N-(tert-Butoxycarbonyl)-2-methyl-L-alanine

IFLAB-BB F2108-0194

BOC-(ME)ALA-OH

BOC-ALPHA-AMINOISOBUTYRIC ACID

BOC-ALPHA-ME-ALA-OH

BOC-ALPHA-METHYLALANINE

BOC-2-AMINOISOBUTYRIC ACID

BOC-AIB-OH

ALPHA-(BOC-AMINO)ISOBUTYRIC ACID

Boc-Aib-OH=Boc-alpha-Me-Ala-OH

n-tert-butoxycarbonyl-2-aminoisobutyric acid

α-(boc-amino)isobutyric acid

N-BOC-2-AMINOISOBUTANOICACID

A-(BOC-AMINO)ISOBUTYRICACID

N-ALPHA-T-BUTYLOXYCARBONYL-2-AMINO-ISOBUTYRIC ACID

BOC-AMINOISOBUTYRRIC ACID ( BOC-AIBA )

Boc-α-methylalanine

N-BOC-2-METHYL-ALANINE

Boc--aminoisobutyric acid, Boc--methylalanine

2-Methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

Alanine, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl-

2-(tert-Butoxycarbonylamino)-2-methylpropionic acid

2-(tert-Butoxycarbonylamino)isobutyric acid

2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-methylpropanoic acid

(Tert-Butoxy)Carbonyl Aib-OH

ANAM-001

N-Boc-2-aminoisobutyric acid, 98+%

N-(tert-butoxycarbonyl)-alpha-methylalanine

N-ALPHA-T-B

2-(Boc-Amino)Isobutyric Acid

Boc-Aib-OH(Boc-α-aMinoisobutyric acid)

2-aMino-4-(tert-butoxy)-2-Methyl-4-oxobutanoic acid

2-((tert-butoxycarbonyl)aMino)-2-Methylpropanoic acid

N-Boc-2-aMino-2-Methylpropanoic acid

2-(Boc-amino)isobutyric Acid N-Boc-alpha-methylalanine Boc-Aib-OH

Boc-a-Me-Ala-OH

2-(<i>tert</i>-ButoxycarbonylaMino)isobutyric acid

Boc-a-aminoisobutyric acid

2-AcetylaMino-2-Methyl-propionic acid

coMpound with 2-Methyl-propan-2-ol

Boc-Aib-OH >=99.0% (T)

Boc-L-Aib-OH

Boc-a-aminoisobutyric acid≥ 98% (HPLC)

Boc-a-methylalanine

N-ALPHA-T-BUTOXYCARBONYL-ALPHA-METHYL-L-ALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-2-AMINO-ISOBUTYRIC ACID

N-ALPHA-T-BOC-ALPHA-AMINOISOBUTYRIC ACID

N-ALPHA-T-BOC-ALPHA-METHYLALANINE

N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-alanine

BOC-Aib

2-(tert-Butoxycarbonylamino)isobutyric Acid &gt

tert Acid