D-Alanine
- Product Name
- D-Alanine
- CAS No.
- 338-69-2
- Chemical Name
- D-Alanine
- Synonyms
- D-ALA;H-D-ALA-OH;(R)-2-aMinopropanoic acid;D-alaine;(R)-Alanine;D-ALPHA-ALANINE;D-AL;Canef;Cranoc;Vastin
- CBNumber
- CB7783360
- Molecular Formula
- C3H7NO2
- Formula Weight
- 89.09
- MOL File
- 338-69-2.mol
D-Alanine Property
- Melting point:
- 291 °C (dec.)(lit.)
- alpha
- -14.5 º (c=10, 6N HCl)
- Boiling point:
- 212.9±23.0 °C(Predicted)
- Density
- 1.4310 (estimate)
- refractive index
- -14 ° (C=2, 6mol/L HCl)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: soluble
- form
- Crystalline Powder or Crystals
- pka
- 2.31±0.10(Predicted)
- color
- White to off-white
- Odor
- odorless
- Water Solubility
- 155 g/L (20 ºC)
- Merck
- 14,204
- BRN
- 1720249
- LogP
- -0.574 (est)
- CAS DataBase Reference
- 338-69-2(CAS DataBase Reference)
- NIST Chemistry Reference
- D-Alanine(338-69-2)
- EPA Substance Registry System
- D-Alanine (338-69-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29224995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A7377
- Product name
- D-Alanine
- Purity
- ≥98% (HPLC)
- Packaging
- 5g
- Price
- $55.2
- Updated
- 2024/03/01
- Product number
- A7377
- Product name
- D-Alanine
- Purity
- ≥98% (HPLC)
- Packaging
- 25g
- Price
- $190
- Updated
- 2024/03/01
- Product number
- A0177
- Product name
- D-Alanine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- A0177
- Product name
- D-Alanine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $82
- Updated
- 2024/03/01
- Product number
- A10231
- Product name
- D-Alanine, 99%
- Packaging
- 5g
- Price
- $38.8
- Updated
- 2024/03/01
D-Alanine Chemical Properties,Usage,Production
Chemical Properties
A white crystalline Powder with no peculiar smell and a sweet taste. It is easily soluble in water, slightly soluble in ethanol, and insoluble in acetone and ether. The decomposition point is 297°C. The specific rotation is [α]25D -1.8° (0.5–2.0 mg/ml, H2O) and [α]25D -14.6° (0.5–2.0 mg/ml, 5 mol/L HCl).
Uses
D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.
Application
D-Alanine is a LHRH-antagonists, e.g., Abarelix (antineoplas- tic)
Definition
ChEBI: D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.
Preparation
D-Alanine can be obtained by hydrolysis and refining of proteins such as gelatin, sericin and corn protein, or it can be synthesized by chemical methods.
General Description
Alanine is a non essential amino acid.
Biochem/physiol Actions
D-Alanine is the non-proteinogenic form of alanine which is used in bacterial cell wall biosynthesis. D-Alanine is used to study the specificity and kinetics of alanine racemase(s) (alaR).
Purification Methods
Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]
References
[1] ISAO UMEMURA. d-Alanine production from dl-alanine by Candida maltosa with asymmetric degrading activity[J]. Applied Microbiology and Biotechnology, 1992, 36 6: 722-726. DOI:10.1007/BF00172182.
[2] TIAN (AUTUMN) QIU. Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice[J]. Communications Biology, 2023: 1-11. DOI:10.1038/s42003-023-05209-y.
[3] AMIT PRIYADARSHI . Structural insights into the alanine racemase from Enterococcus faecalis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2009, 1794 7: Pages 1030-1040. DOI:10.1016/j.bbapap.2009.03.006.
[4] CINDY J. LEE Jonathan V S Tian A Qiu. d-Alanine: Distribution, origin, physiological relevance, and implications in disease[J]. Biochimica et biophysica acta. Proteins and proteomics, 2020, 1868 11: Article 140482. DOI:10.1016/j.bbapap.2020.140482.
D-Alanine Preparation Products And Raw materials
Raw materials
Preparation Products
D-Alanine Suppliers
- Tel
- 0510-88770633 13961738808
- jingyaobiotech@126.com
- Country
- China
- ProdList
- 324
- Advantage
- 55
- Tel
- 027-88188016 18717196322
- 1764683941@qq.com
- Country
- China
- ProdList
- 5749
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 4986
- Advantage
- 55
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
View Lastest Price from D-Alanine manufacturers
- Product
- D-Alanine 338-69-2
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-05-21
- Product
- D-Alanine 338-69-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min AJI
- Supply Ability
- 1000kg
- Release date
- 2021-09-22
- Product
- D-alanine 338-69-2
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-11-14