ChemicalBook > CAS DataBase List > D-Alanine

D-Alanine

Product Name
D-Alanine
CAS No.
338-69-2
Chemical Name
D-Alanine
Synonyms
D-ALA;H-D-ALA-OH;(R)-2-aMinopropanoic acid;D-alaine;(R)-Alanine;D-ALPHA-ALANINE;D-AL;Canef;Cranoc;Vastin
CBNumber
CB7783360
Molecular Formula
C3H7NO2
Formula Weight
89.09
MOL File
338-69-2.mol
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D-Alanine Property

Melting point:
291 °C (dec.)(lit.)
alpha 
-14.5 º (c=10, 6N HCl)
Boiling point:
212.9±23.0 °C(Predicted)
Density 
1.4310 (estimate)
refractive index 
-14 ° (C=2, 6mol/L HCl)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
Crystalline Powder or Crystals
pka
2.31±0.10(Predicted)
color 
White to off-white
Odor
odorless
optical activity
Consistent with structure
Water Solubility 
155 g/L (20 ºC)
Merck 
14,204
BRN 
1720249
LogP
-0.574 (est)
CAS DataBase Reference
338-69-2(CAS DataBase Reference)
NIST Chemistry Reference
D-Alanine(338-69-2)
EPA Substance Registry System
D-Alanine (338-69-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7377
Product name
D-Alanine
Purity
≥98% (HPLC)
Packaging
5g
Price
$59.1
Updated
2025/07/31
Sigma-Aldrich
Product number
A7377
Product name
D-Alanine
Purity
≥98% (HPLC)
Packaging
25g
Price
$203
Updated
2025/07/31
TCI Chemical
Product number
A0177
Product name
D-Alanine
Purity
>98.0%(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
A0177
Product name
D-Alanine
Purity
>98.0%(T)
Packaging
25g
Price
$82
Updated
2025/07/31
Sigma-Aldrich
Product number
A7377
Product name
D-Alanine
Purity
≥98% (HPLC)
Packaging
100g
Price
$678
Updated
2025/07/31
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D-Alanine Chemical Properties,Usage,Production

Chemical Properties

A white crystalline Powder with no peculiar smell and a sweet taste. It is easily soluble in water, slightly soluble in ethanol, and insoluble in acetone and ether. The decomposition point is 297°C. The specific rotation is [α]25D -1.8° (0.5–2.0 mg/ml, H2O) and [α]25D -14.6° (0.5–2.0 mg/ml, 5 mol/L HCl).

Uses

D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.

Application

D-Alanine is a LHRH-antagonists, e.g., Abarelix (antineoplas- tic)

Definition

ChEBI: D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.

Preparation

D-Alanine can be obtained by hydrolysis and refining of proteins such as gelatin, sericin and corn protein, or it can be synthesized by chemical methods.

General Description

Alanine is a non essential amino acid.

Biochem/physiol Actions

D-Alanine is the non-proteinogenic form of alanine which is used in bacterial cell wall biosynthesis. D-Alanine is used to study the specificity and kinetics of alanine racemase(s) (alaR).

Purification Methods

Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]

References

[1] ISAO UMEMURA. d-Alanine production from dl-alanine by Candida maltosa with asymmetric degrading activity[J]. Applied Microbiology and Biotechnology, 1992, 36 6: 722-726. DOI:10.1007/BF00172182.
[2] TIAN (AUTUMN) QIU. Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice[J]. Communications Biology, 2023: 1-11. DOI:10.1038/s42003-023-05209-y.
[3] AMIT PRIYADARSHI . Structural insights into the alanine racemase from Enterococcus faecalis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2009, 1794 7: Pages 1030-1040. DOI:10.1016/j.bbapap.2009.03.006.
[4] CINDY J. LEE   Jonathan V S Tian A Qiu. d-Alanine: Distribution, origin, physiological relevance, and implications in disease[J]. Biochimica et biophysica acta. Proteins and proteomics, 2020, 1868 11: Article 140482. DOI:10.1016/j.bbapap.2020.140482.

D-Alanine Preparation Products And Raw materials

Raw materials

2-Acetylamino-propionic acid

Preparation Products

BOC-D-Alanine Alitame Enalapril Imidapril D-Alaninamide, L-.alpha.-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-, hydrate (2:5) Glycine Bilirubin D-Cycloserine DL-Alanine
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View Lastest Price from D-Alanine manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
D-Alanine 338-69-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99%
Supply Ability
20000T
Release date
2025-06-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Alanine 338-69-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min AJI
Supply Ability
1000kg
Release date
2021-09-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
D-Alanine 338-69-2
Price
US $0.00-0.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

338-69-2, D-AlanineRelated Search:

Phenprobamate EC 2.6.1.2 D(+)-Tryptophan D-Aspartic acid D-Valine D-Alanine Methyl Ester Hydrochloride D-Alanyl-D-alanine Citric acid Ascoric Acid 1-Amino-1-cyclohexanecarboxylic acid D(-)-allo-Threonine D-tert-Butylglycine 4-Hydroxy-D-(-)-2-phenylglycine N-Methyl-D-aspartic acid D-Serine L-Alanine D-Cystine Cycloleucine

  • D-ALANINE, >=98% (HPLC)
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