BOC-VAL-NH2

Product Name: BOC-VAL-NH2
CAS No.: 35150-08-4
Chemical Name: BOC-VAL-NH2
Synonyms: BOC-VAL-NH2;BOC-L-VAL-NH2;BOC-L-VALINE AMIDE;(Tert-Butoxy)Carbonyl Val-NH2;Boc-L-valine amide≥ 98% (HPLC);N~2~-(tert-butoxycarbonyl)valinamide;N-tert-Butoxycarbonyl-L-valine amide;N-ALPHA-T-BUTOXYCARBONYL-L-VALINE AMIDE;tert-butyl N-[(1S)-1-carbamoyl-2-methyl-propyl]carbamate;(S)-tert-butyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate
CBNumber: CB4308283
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: 35150-08-4.mol

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BOC-VAL-NH2 Property

Melting point:: 156-157 °C(Solv: methanol (67-56-1))
Boiling point:: 361.7±25.0 °C(Predicted)
Density: 1.042±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Dichloromethane, Ethyl Acetate, Methanol, THF
form: Solid
pka: 11.30±0.46(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 265273
Product name: Boc-L-valine amide
Packaging: 2g
Price: $202
Updated: 2021/12/16

TRC

Product number: B673495
Product name: Boc-L-ValineAmide
Packaging: 25g
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0001835
Product name: BOC-VAL-NH2
Purity: 95.00%
Packaging: 1G
Price: $678
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0001835
Product name: BOC-VAL-NH2
Purity: 95.00%
Packaging: 5G
Price: $1039.5
Updated: 2021/12/16

Matrix Scientific

Product number: 140427
Product name: tert-Butyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate
Purity: >97%
Packaging: 1g
Price: $268
Updated: 2021/12/16

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BOC-VAL-NH2 Chemical Properties,Usage,Production

Uses

Boc-L-Valine Amide is an intermediate in the synthesis of QZ59S-SSS (Q990000) which acts as a potential inhibitor of human P-glycoprotein used to improve the efficacy of cancer chemotherapy.

Synthesis

13734-41-3

35150-08-4

General procedure for the synthesis of tert-butyl (S)-(1-amino-3-methyl-1-oxo-2-butyl)carbamate from Boc-L-valine: to a colorless solution of 150 mg (0.50 mmol) of Boc-L-valine in 10 mL of THF was added 67 μL (0.70 mmol, 1.4 eq.) of ethyl chloroformate at 0 °C and 209 μL ( 1.5 mmol, 3.0 eq.) triethylamine. After stirring at 0 °C for 30 min, 0.75 mL of 1.0 M aqueous ammonium chloride (0.75 mmol, 1.5 equiv) was added to the colorless suspension. The mixture was continued to be stirred at 0 °C for 30 min, followed by the addition of 5 mL of water. The colorless clear solution was extracted with 30 mL of ethyl acetate and the aqueous layer was extracted with another 20 mL of ethyl acetate. The organic layers were combined, washed with 5 mL of brine and dried with anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate) to give 129 mg (86% yield) of tert-butyl (S)-(1-amino-3-methyl-1-oxo-2-butyl)carbamate. The product was a colorless solid, melting point: 149-152 °C; [α]30D = -2.4 (c 1.00, methanol); 1H NMR (400 MHz, CDCl3): δ 0.94 (d, J = 6.8 Hz, 3H, CH3CH), 0.99 (d, J = 6.8 Hz, 3H, CH3CH), 1.45 (s, 9H, (CH3)3C ), 2.16 (ddd, J = 6.7,6.8,6.8 Hz, 1H, CH(CH3)2), 3.96 (dd, J = 6.7,7.8 Hz, 1H, CHCO), 5.03,5.42,5.89 (br, br, br, 1H, 1H, 1H, NH, NH2); 13C NMR (100 MHz, CDCl3) : δ17.8,19.3,28.3,30.8,59.5,79.9,156.0,174.4; IR (KBr, vmax/cm-1): 3386 (CONH), 3345 (CONH), 3205 (CONH), 1680 (CON), 1641 (CON); HRMS (ESI-TOF): Calculated value for C10H20N2O3Na (M + Na)+: 239.1366, measured value: 239.1340. Enantiomeric ratio was determined by HPLC (Chiralcel OD column: hexane/2-propanol = 95/5): retention time 9.4 min.

References

[1] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 25, p. 4771 - 4774
[3] Angewandte Chemie, International Edition, 2009, vol. 48, # 23, p. 4198 - 4201
[4] Bulletin of the Chemical Society of Japan, 1988, vol. 61, # 7, p. 2647 - 2648
[5] Tetrahedron, 2009, vol. 65, # 46, p. 9536 - 9541

BOC-VAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-VAL-NH2 Suppliers

China 69 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 1 United States 13 Global 90

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Sichuan Ampebiochem Co., Ltd.

Tel: 028-65294243 13981822079;18682730901
Email: sales@ampebiochem.com
Country: China
ProdList: 1000
Advantage: 58

Nanjing Derno Pharmaceutical Technology Co., Ltd.

Tel: 025-86957866 13952093866
Fax: 025-68661287
Email: sales@dernopharm.com
Country: China
ProdList: 932
Advantage: 58

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
ProdList: 8258
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Wuxi Asia Peptide Biotechnology Limited Company

Tel: 0510-83583050 13771062561
Fax: 0510-83583039
Email: willsun@peptide-search.com
Country: China
ProdList: 6716
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from BOC-VAL-NH2 manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Val-NH2 35150-08-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Shaanxi Dideu Medichem Co. Ltd

Product: BOC-VAL-NH2 35150-08-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-09

Career Henan Chemical Co

Product: BOC-VAL-NH2 35150-08-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

35150-08-4, BOC-VAL-NH2Related Search:

BOC-VAL-NH2 BOC-D-VAL-NH2 BOC-VAL-GLY-OME BOC-VAL-LEU-GLY-ARG-OH BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE BOC-ILE-GLY-OH BOC-VAL-GLY-ARG-AMC HCL N-T-BOC-VAL-LEU-GLY-ARG P-NITROANILIDE HYDROBROMIDE BOC-VAL-PRO-ARG-MCA BOC-VAL-GLY-OH BOC-VAL-LEU-LYS-AMC ACETATE BOC-ILE-GLU-GLY-ARG-AMC ACETATE SALT BOC-VAL-PRO-ARG-AMC HCL BOC-ILE-N(OCH3)CH3 BOC-VAL-PRO-OH BOC-ILE-GLY-OME BOC-VAL-VAL-OH N-T-BOC-ILE-GLU-GLY-ARG 7-AMIDO-4-METHYL-COUMARIN HYDROCHLORIDE

N-ALPHA-T-BUTOXYCARBONYL-L-VALINE AMIDE

N-tert-Butoxycarbonyl-L-valine amide

BOC-L-VALINE AMIDE

BOC-L-VAL-NH2

BOC-VAL-NH2

(S)-tert-butyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate

N-[(1S)-1-carbamoyl-2-methyl-propyl]carbamic acid tert-butyl ester

N-[(1S)-1-carbamoyl-2-methylpropyl]carbamic acid tert-butyl ester

N~2~-(tert-butoxycarbonyl)valinamide

tert-butyl N-[(1S)-1-carbamoyl-2-methyl-propyl]carbamate

tert-butyl N-[(2S)-1-amino-3-methyl-1-oxo-butan-2-yl]carbamate

tert-butyl N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate

tert-Butyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate

Boc-L-valine amide≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl Val-NH2

Carbamic acid, [(1S)-1-(aminocarbonyl)-2-methylpropyl]-,1,1-dimethylethyl ester

Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, 1,1-dimethylethyl ester

35150-08-4