Boc-L-Threonine

Product Name: Boc-L-Threonine
CAS No.: 2592-18-9
Chemical Name: Boc-L-Threonine
Synonyms: BOC-THR-OH;BOC-L-THR-OH;BOC-THREONINE;Boc-Thr-OH 98%;BOC-L-THREONINE;N-Boc-Threonine;Boc-L-Threionine;Boc-Thr-OH, 95+%;Boc-Thr-OH, 98.5%;BOC-L-THREONINE-OH
CBNumber: CB1491517
Molecular Formula: C9H17NO5
Formula Weight: 219.24
MOL File: 2592-18-9.mol

More

Less

Boc-L-Threonine Property

Melting point:: 80-82 °C(lit.)
Boiling point:: 360.05°C (rough estimate)
alpha: -8.5 º (c=1, acetic acid)
Density: 1.2470 (rough estimate)
refractive index: -7 ° (C=1, AcOH)
storage temp.: -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.60±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D 8.5±1°, c = 1% in acetic acid
BRN: 2331474
InChI: InChI=1S/C9H17NO5/c1-5(11)6(7(12)13)10-8(14)15-9(2,3)4/h5-6,11H,1-4H3,(H,10,14)(H,12,13)/t5-,6+/m1/s1
InChIKey: LLHOYOCAAURYRL-RITPCOANSA-N
SMILES: C(O)(=O)[C@H]([C@H](O)C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 2592-18-9(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
HS Code: 29241990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53065
Product name: Boc-Thr-OH
Purity: Novabiochem?
Packaging: 25g
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.53065
Product name: Boc-Thr-OH
Purity: Novabiochem?
Packaging: 100g
Price: $522
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15505
Product name: Boc-Thr-OH
Purity: ≥98.5% (T)
Packaging: 25g
Price: $88
Updated: 2023/06/20

TCI Chemical

Product number: B1638
Product name: N-(tert-Butoxycarbonyl)-L-threonine
Purity: >98.0%(T)
Packaging: 10g
Price: $453
Updated: 2025/07/31

TRC

Product number: B668005
Product name: N-Boc-L-threonine
Packaging: 50g
Price: $360
Updated: 2021/12/16

More

Less

Boc-L-Threonine Chemical Properties,Usage,Production

Chemical Properties

WHITE AMORPHOUS POWDER

Uses

N-Boc-L-threonine is an N-Boc-protected form of L-Threonine (T405500). L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

72-19-5

24424-99-5

2592-18-9

The general procedure for the synthesis of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid from L-threonine and di-tert-butyl dicarbonate was as follows: 1. To a methanol (5 mL) solution of L-threonine (400 mg, 3.36 mmol), a water (5 mL) solution of sodium bicarbonate (434 mg, 5.17 mmol) was added, followed by di-tert-butyl dicarbonate (1.07 g, 4.90 mmol). 2. The reaction mixture was stirred at room temperature for 3 days. 3. Upon completion of the reaction, the solvent was removed by vacuum distillation. 4. 4. The residue was diluted with water (20 mL) and washed with ether (2 x 20 mL). 5. The aqueous layer was acidified with saturated aqueous sodium bisulfite and then extracted with 2-methyltetrahydrofuran. 6. The organic layer was dried over anhydrous sodium sulfate and subsequently concentrated in vacuo to afford the title compound (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid as a white solid (730 mg, 99% yield). 7. The product was characterized by 1H NMR (400 MHz, CDCl3) and LC-MS: 1H NMR δ 1.24 (d, 3H), 1.44 (s, 9H), 4.26 (d, 1H), 4.40 (d, 1H), 5.52 (d, 1H), 5.69 (br s, 1H); LCMS Rt = 1.68 min, MS m/z 218 [M + H]+.

References

[1] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 161; 162
[2] Patent: WO2013/110643, 2013, A1. Location in patent: Paragraph 00118; 00119
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 8, p. 1795 - 1802
[4] Patent: CN102993200, 2016, B. Location in patent: Paragraph 0043; 0044; 0045
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5770 - 5781

Boc-L-Threonine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Boc-L-Threonine Suppliers

Americas 1 Belgium 1 China 241 Europe 3 France 3 Germany 6 Hungary 1 India 30 Japan 7 South Korea 1 Switzerland 5 United Kingdom 12 United States 51 Global 362

Suzhou Daolan Biomedical Technology Co., Ltd.

Tel: 13771737464
Email: sales@dolanchem.com
Country: China
ProdList: 2172
Advantage: 58

Zhangjiagang Specom Biochemical Co., Ltd.

Tel: 512-0512-58992291,58992287 18606280718
Email: admin@spbiochem.com
Country: China
ProdList: 254
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from Boc-L-Threonine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-L-Threonine 2592-18-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-23

Hebei Chuanghai Biotechnology Co., Ltd

Product: Boc-L-Threonine 2592-18-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Boc-L-Threonine 2592-18-9
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-02

2592-18-9, Boc-L-ThreonineRelated Search:

L-Threonine N-Carbobenzyloxyglycine tert-Butyl carbazate DI-TERT-BUTYL ETHER BOC-THR(ME)-OH N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine Boc-Thr(Bzl)-OH Boc-O-tert-butyl-L-threonine BOC-D-THREONINE(BZL)-OH BOC-D-THREONINE extrapure,N-ALPHA-T-BOC-D-THREONINE / (2R,3S),N-ALPHA-T-BOC-D-THREONINE,BOC-D-THREONINE BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-THR(P-CHLORO-BZL)-OH DCHA N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID BOC-L-THREONINE DCHA tert-butyl [R-(R*,S*)]-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate BOC-THR(BZL)-ONP Methyl N-(tert-butoxycarbonyl)-L-threoninate BPOC-THR(TBU)-OSU

N-(TERT-BUTOXYCARBONYL)-L-THREONINE 98%

N-T-BOC-L-THREONINE CRYSTALLINE

Boc-L-Threionine

N-ALPHA-T-BUTYLOXYCARBONYL-L-THREONINE

N-Boc-L-threonine, 98+%

BOC-L-THREONINE extrapure

N-(tert-Butoxycarbonyl)-L-threonine, Boc-L-threonine

BOC-L-THREONINE

BOC-L-THREONINE-OH

BOC-L-THR-OH

BOC-THR-OH

BOC-THREONINE

(Tert-Butoxy)Carbonyl Thr-OH

Boc-Thr-OH, 98.5%

BOC-L-Threonine,98%

L-Threonine, N-BOC protected

BOC-L-Threonine(BOC-L-Thr-OH)

N-Boc-L-threonine Boc-Thr-OH

3-Hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-

tert-Butoxycarbonyl-L-threonine

(2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutanoic acid

(2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutyric acid

(2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutyric acid

N-[(1,1-Dimethylethoxy)carbonyl]-L-threonine

N-Boc-Threonine

Boc-L-threonine≥ 98% (HPLC)

N-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-(TERT-BUTOXYCARBONYL)-L-THREONINE

N-(TERT-BUTOXYCARBONYL)-P-THREONINE

N-T-BUTOXYCARBONYL-L-THREONINE

N-ALPHA-T-BUTOXYCARBONYL-L-THREONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-ALPHA-T-BOC-L-THREONINE

Boc-Thr-OH, 95+%

N-(tert-Butoxycarbonyl)-L-threonine &gt

Boc-L-Threonine USP/EP/BP

(2S,3R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

N-tert-Boc-L-threonine

Boc-Thr-OH 98%

2592-18-9

592-18-9

CH3CHOHCHCOOHNHCOOCCH33

Protected & Labeled Amino Acids

Boc-Amino Acids

Amino Acids (N-Protected)

Amino Acid Derivatives

Peptide Synthesis

Threonine

Specialty Synthesis

Threonine [Thr, T]

Boc-Amino Acids and Derivative

Amino Acids

Amino Acids (N-Protected)

Biochemistry

Boc-Amino Acids

Boc-Amino acid series