Boc-L-Threonine

Product Name: Boc-L-Threonine
CAS No.: 2592-18-9
Chemical Name: Boc-L-Threonine
Synonyms: BOC-THR-OH;BOC-L-THR-OH;BOC-THREONINE;Boc-Thr-OH 98%;BOC-L-THREONINE;N-Boc-Threonine;Boc-L-Threionine;Boc-Thr-OH, 95+%;Boc-Thr-OH, 98.5%;BOC-L-THREONINE-OH
CBNumber: CB1491517
Molecular Formula: C9H17NO5
Formula Weight: 219.24
MOL File: 2592-18-9.mol

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Boc-L-Threonine Property

Melting point:: 80-82 °C(lit.)
Boiling point:: 360.05°C (rough estimate)
alpha: -8.5 º (c=1, acetic acid)
Density: 1.2470 (rough estimate)
refractive index: -7 ° (C=1, AcOH)
storage temp.: -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.60±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D 8.5±1°, c = 1% in acetic acid
BRN: 2331474
InChI: InChI=1S/C9H17NO5/c1-5(11)6(7(12)13)10-8(14)15-9(2,3)4/h5-6,11H,1-4H3,(H,10,14)(H,12,13)/t5-,6+/m1/s1
InChIKey: LLHOYOCAAURYRL-RITPCOANSA-N
SMILES: C(O)(=O)[C@H]([C@H](O)C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 2592-18-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53065
Product name: Boc-Thr-OH
Purity: Novabiochem?
Packaging: 25g
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.53065
Product name: Boc-Thr-OH
Purity: Novabiochem?
Packaging: 100g
Price: $522
Updated: 2024/03/01

Sigma-Aldrich

Product number: 15505
Product name: Boc-Thr-OH
Purity: ≥98.5% (T)
Packaging: 25g
Price: $88
Updated: 2023/06/20

TCI Chemical

Product number: B1638
Product name: N-(tert-Butoxycarbonyl)-L-threonine
Purity: >98.0%(T)
Packaging: 10g
Price: $453
Updated: 2025/07/31

TRC

Product number: B668005
Product name: N-Boc-L-threonine
Packaging: 50g
Price: $360
Updated: 2021/12/16

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Boc-L-Threonine Chemical Properties,Usage,Production

Chemical Properties

WHITE AMORPHOUS POWDER

Uses

N-Boc-L-threonine is an N-Boc-protected form of L-Threonine (T405500). L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

72-19-5

24424-99-5

2592-18-9

The general procedure for the synthesis of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid from L-threonine and di-tert-butyl dicarbonate was as follows: 1. To a methanol (5 mL) solution of L-threonine (400 mg, 3.36 mmol), a water (5 mL) solution of sodium bicarbonate (434 mg, 5.17 mmol) was added, followed by di-tert-butyl dicarbonate (1.07 g, 4.90 mmol). 2. The reaction mixture was stirred at room temperature for 3 days. 3. Upon completion of the reaction, the solvent was removed by vacuum distillation. 4. 4. The residue was diluted with water (20 mL) and washed with ether (2 x 20 mL). 5. The aqueous layer was acidified with saturated aqueous sodium bisulfite and then extracted with 2-methyltetrahydrofuran. 6. The organic layer was dried over anhydrous sodium sulfate and subsequently concentrated in vacuo to afford the title compound (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid as a white solid (730 mg, 99% yield). 7. The product was characterized by 1H NMR (400 MHz, CDCl3) and LC-MS: 1H NMR δ 1.24 (d, 3H), 1.44 (s, 9H), 4.26 (d, 1H), 4.40 (d, 1H), 5.52 (d, 1H), 5.69 (br s, 1H); LCMS Rt = 1.68 min, MS m/z 218 [M + H]+.

References

[1] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 161; 162
[2] Patent: WO2013/110643, 2013, A1. Location in patent: Paragraph 00118; 00119
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 8, p. 1795 - 1802
[4] Patent: CN102993200, 2016, B. Location in patent: Paragraph 0043; 0044; 0045
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5770 - 5781

Boc-L-Threonine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-Threonine Suppliers

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View Lastest Price from Boc-L-Threonine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-L-Threonine 2592-18-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-23

Hebei Chuanghai Biotechnology Co., Ltd

Product: Boc-L-Threonine 2592-18-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Boc-L-Threonine 2592-18-9
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-02

2592-18-9, Boc-L-ThreonineRelated Search:

L-Threonine N-Carbobenzyloxyglycine tert-Butyl carbazate DI-TERT-BUTYL ETHER BOC-THR(ME)-OH N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine Boc-Thr(Bzl)-OH Boc-O-tert-butyl-L-threonine BOC-D-THREONINE(BZL)-OH BOC-D-THREONINE extrapure,N-ALPHA-T-BOC-D-THREONINE / (2R,3S),N-ALPHA-T-BOC-D-THREONINE,BOC-D-THREONINE BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-THR(P-CHLORO-BZL)-OH DCHA N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID BOC-L-THREONINE DCHA tert-butyl [R-(R*,S*)]-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate BOC-THR(BZL)-ONP Methyl N-(tert-butoxycarbonyl)-L-threoninate BPOC-THR(TBU)-OSU

N-(TERT-BUTOXYCARBONYL)-L-THREONINE 98%

N-T-BOC-L-THREONINE CRYSTALLINE

Boc-L-Threionine

N-ALPHA-T-BUTYLOXYCARBONYL-L-THREONINE

N-Boc-L-threonine, 98+%

BOC-L-THREONINE extrapure

N-(tert-Butoxycarbonyl)-L-threonine, Boc-L-threonine

BOC-L-THREONINE

BOC-L-THREONINE-OH

BOC-L-THR-OH

BOC-THR-OH

BOC-THREONINE

(Tert-Butoxy)Carbonyl Thr-OH

Boc-Thr-OH, 98.5%

BOC-L-Threonine,98%

L-Threonine, N-BOC protected

BOC-L-Threonine(BOC-L-Thr-OH)

N-Boc-L-threonine Boc-Thr-OH

3-Hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-

tert-Butoxycarbonyl-L-threonine

(2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutanoic acid

(2S,3R)-2-(tert-Butoxycarbonylamino)-3-hydroxybutyric acid

(2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutyric acid

N-[(1,1-Dimethylethoxy)carbonyl]-L-threonine

N-Boc-Threonine

Boc-L-threonine≥ 98% (HPLC)

N-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-(TERT-BUTOXYCARBONYL)-L-THREONINE

N-(TERT-BUTOXYCARBONYL)-P-THREONINE

N-T-BUTOXYCARBONYL-L-THREONINE

N-ALPHA-T-BUTOXYCARBONYL-L-THREONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-ALPHA-T-BOC-L-THREONINE

Boc-Thr-OH, 95+%

N-(tert-Butoxycarbonyl)-L-threonine &gt

Boc-L-Threonine USP/EP/BP

(2S,3R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

N-tert-Boc-L-threonine

Boc-Thr-OH 98%

2592-18-9

592-18-9

CH3CHOHCHCOOHNHCOOCCH33

Protected & Labeled Amino Acids

Boc-Amino Acids

Amino Acids (N-Protected)

Amino Acid Derivatives

Peptide Synthesis

Threonine

Specialty Synthesis

Threonine [Thr, T]

Boc-Amino Acids and Derivative

Amino Acids

Amino Acids (N-Protected)

Biochemistry

Boc-Amino Acids

Boc-Amino acid series