BOC-THR(ME)-OH
- Product Name
- BOC-THR(ME)-OH
- CAS No.
- 48068-25-3
- Chemical Name
- BOC-THR(ME)-OH
- Synonyms
- BOC-THR(ME);BOC-THR(ME)-OH;Boc-L-Thr(Me)-OH;BOC-O-METHYL-L-THREONINE;BOC-THR(ME)-OH USP/EP/BP;N-Boc-O-Methyl-L-threonine;N-Boc-O-methyl-L-threonine,95%;(Tert-Butoxy)Carbonyl Thr(Me)-OH;O-Methyl-L-threonine, N-BOC protected;N-(tert-butoxycarbonyl)-O-methyl-L-threonine
- CBNumber
- CB3748587
- Molecular Formula
- C10H19NO5
- Formula Weight
- 233.26
- MOL File
- 48068-25-3.mol
BOC-THR(ME)-OH Property
- Boiling point:
- 362.1±37.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.50±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C10H19NO5/c1-6(15-5)7(8(12)13)11-9(14)16-10(2,3)4/h6-7H,1-5H3,(H,11,14)(H,12,13)/t6-,7+/m1/s1
- InChIKey
- VWSUOKFUIPMDDX-RQJHMYQMSA-N
- SMILES
- C(O)(=O)[C@H]([C@H](OC)C)NC(OC(C)(C)C)=O
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B657418
- Product name
- Boc-O-Methyl-L-threonine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 236634
- Product name
- Boc-O-methyl-L-threonine
- Packaging
- 250mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- 4156-1-W1
- Product name
- O-Methyl-L-threonine, N-Boc protected
- Packaging
- 25g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- AS33266
- Product name
- Boc-O-Methyl-L-threonine
- Purity
- 96+%
- Packaging
- 25g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- OR61332
- Product name
- O-Methyl-L-threonine,N-BOCprotected
- Purity
- 98%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
BOC-THR(ME)-OH Chemical Properties,Usage,Production
Uses
Boc-Thr(Me)-OH is a threonine derivative[1].
Synthesis
4144-02-9
24424-99-5
48068-25-3
GENERAL METHOD: O-Methyl-L-threonine (10 g, 75.11 mmol) was dissolved in a solvent mixture of THF (350 mL) and water (350 mL) and cooled to 0 °C. NaHCO3 (18.93 g, 225.32 mmol) and di-tert-butyl dicarbonate (Boc2O, 24.59 g, 112.66 mmol) were added sequentially, and the reaction mixture was gradually warmed to room temperature and stirred for 18 hours. Upon completion of the reaction, the pH was adjusted to 4 with aqueous KHSO4 to quench the reaction, followed by extraction with EtOAc (5 × 150 mL). The organic layers were combined, dried with Na2SO4 and concentrated under reduced pressure. The residue was ground with heptane to afford (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-methoxybutyric acid as a white solid (16.50 g, 94% yield).1H NMR (400 MHz, CDCl3): δ 1.22 (d, 3H), 1.45 (s, 9H), 3.28 (s, 3H), 3.98 (br d, 1H). 4.38 (d, 1H), 5.28 (d, 1H), 10.40-10.60 (br s, 1H).
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
BOC-THR(ME)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-THR(ME)-OH manufacturers
- Product
- Boc-Thr(me)-OH 48068-25-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-22
- Product
- BOC-THR(ME)-OH 48068-25-3
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23