Boc-Thr(Bzl)-OH

Product Name: Boc-Thr(Bzl)-OH
CAS No.: 15260-10-3
Chemical Name: Boc-Thr(Bzl)-OH
Synonyms: PLIT-017;BOC-THR-OH;BOC-L-THR-OH;BOC-THR(BZL);BOC-THREONINE;BOC-L-THR(BZL);BOC-THR(BZL)-OH;Bor-Thr(Bz1)-OH;BOC-Thr (Obzl) OH;BOC-L-THR(BZL)-OH
CBNumber: CB8164096
Molecular Formula: C16H23NO5
Formula Weight: 309.36
MOL File: 15260-10-3.mol

More

Less

Boc-Thr(Bzl)-OH Property

Melting point:: 80-82 °C(lit.)
alpha: 22 º (c=2 in 95% ethanol)
Boiling point:: 461.5±45.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
refractive index: 16.5 ° (C=1, MeOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.50±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D +16.5±1°, c = 1% in methanol
BRN: 3065591
InChI: InChI=1S/C16H23NO5/c1-11(21-10-12-8-6-5-7-9-12)13(14(18)19)17-15(20)22-16(2,3)4/h5-9,11,13H,10H2,1-4H3,(H,17,20)(H,18,19)/t11-,13+/m1/s1
InChIKey: CTXPLTPDOISPTE-YPMHNXCESA-N
SMILES: C(O)(=O)[C@H]([C@H](OCC1=CC=CC=C1)C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 15260-10-3(CAS DataBase Reference)
EPA Substance Registry System: L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- (15260-10-3)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 2924 29 70

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53004
Product name: Boc-Thr(Bzl)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $182
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53004
Product name: Boc-Thr(Bzl)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $566
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53004
Product name: Boc-Thr(Bzl)-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2270
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53004
Product name: Boc-Thr(Bzl)-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2270
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15405
Product name: Boc-Thr(Bzl)-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $69
Updated: 2022/05/15

More

Less

Boc-Thr(Bzl)-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

Boc-O-benzyl-L-threonine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Application

Boc-Thr(Bzl)-OH is a standard building block for introduction of threonine amino-acid residues by Boc SPPS.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2592-18-9

100-39-0

15260-10-3

To a stirred solution of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid (250 g, 1.44 mol) in DMF (1 L) was added 60% sodium hydride (68 g, 2.85 mol) in batches at -20 °C and protected by nitrogen and stirring was continued for 2 hours. Subsequently, benzyl bromide (167 mL, 1.36 mol) was slowly added dropwise and the reaction mixture was continued to be stirred at room temperature for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction was quenched with ice water and subsequently washed with ether (2 x 250 mL). The aqueous layer was separated and the pH was adjusted to about 2 with citric acid solution, followed by extraction with ethyl acetate (2 x 300 mL). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (2S,3R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)butanoic acid (320 g, 90% yield) as a thick paste.1H-NMR (500 MHz, DMSO-d6) data: δ 12.64 (broad single peak, 1H), 7.34-7.25 (multiple peaks, 5H), and 6.46 (double peak, J=8.5Hz, 1H), 4.53 (double peak, J=11.5Hz, 1H), 4.39 (double peak, J=12.0Hz, 1H), 4.00-3.98 (multiple peaks, 2H), 1.39 (single peak, 9H), 1.15 (double peak, J=6.0Hz, 3H).

References

[1] Patent: WO2018/26763, 2018, A1. Location in patent: Page/Page column 63
[2] Patent: WO2014/120786, 2014, A1. Location in patent: Paragraph 0101
[3] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 0093
[4] Patent: WO2017/195069, 2017, A1. Location in patent: Page/Page column 66
[5] Bulletin of the Chemical Society of Japan, 1995, vol. 68, # 5, p. 1369 - 1377

Boc-Thr(Bzl)-OH Preparation Products And Raw materials

Raw materials

L-Threonine 1,4-Dioxane

Preparation Products

More

Less

Boc-Thr(Bzl)-OH Suppliers

Americas 1 China 226 Europe 3 France 1 Germany 6 Hungary 1 India 11 Japan 6 Poland 1 South Korea 1 Switzerland 4 United Kingdom 9 United States 53 Global 323

Sichuan HongRi Pharma-Tech Co., Ltd

Tel: 02888457210; 18380436509
Fax: 0838-2822568
Email: 2065506070@qq.com
Country: China
ProdList: 2025
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from Boc-Thr(Bzl)-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-Thr(Bzl)-OH 15260-10-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Thr(Bzl)-OH 15260-10-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-27

Hebei Zhanyao Biotechnology Co. Ltd

Product: Boc-O-Benzyl-L-Threonine 15260-10-3
Price: US $10.00/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-12-14

15260-10-3, Boc-Thr(Bzl)-OHRelated Search:

tert-Butyl peroxyacetate tert-Butanol L-Threonine Benzyl chloride Benzyl benzoate Benzyl alcohol Benzyl isocyanate Benzyl nicotinate Benzyl N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine N-ALPHA-T-BOC-O-BENZYL-D-THREONINE / (2R,3S),N-ALPHA-T-BOC-O-BENZYL-D-THREONINE,BOC-O-BENZYL-D-THREONINE Boc-L-Threonine BOC-THR(P-CHLORO-BZL)-OH DCHA BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-O-BENZYL-L-THREONINE N-CARBOXY ANHYDRIDE BOC-O-BENZYL-L-THREONINE P-NITROPHENYL ESTER,BOC-O-BENZYL-L-THREONINE 4-NITROPHENYL ESTER BOC-THR(BZL)-OSU BOC-O-BENZYL-D-THREONINE 4-OXYMETHYLPHENYLACETAMIDOMETHYL RESIN,BOC-O-BENZYL-D-THREONINE MERRIFIELD RESIN

BOC-THR-OH

BOC-THR(BZL)-OH

Butoxacarbonylbenzylthreonine

Butoxycarbonylbenzylthreonine

N-T-boc-O-benzyl-L-threonine*crystalline

O-benzyl-N-tert-butoxycarbonyl-L-threonine

N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE

NALPHA-tert-Butoxycarbonyl-O-benzyl-L-threonine

BOC-Thr (Obzl) OH

(2S,3R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)butanoic acid

(2S,3R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)butanoic acid

L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

Boc-O-Bzl-L-Thr-OH

N-(tert-Butyloxycarbonyl)-O-benzyl-L-threonine

N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-threonine

Boc-O-benzyl-L-threonine, N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine

Boc-O-Benzyl-L-threo

N-Boc-O-benzyl-L-threonine Boc-Thr(Bzl)-OH

Bor-Thr(Bz1)-OH

2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-phenylmethoxybutanoate

n-[(1,1-dimethylethoxy)carbonyl]-o-(phenylmethyl)-l-threonin

TBOC-L-THREONINE (BZL)

T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE

N-T-BUTOXYCARBONYL-L-THREONINE

N-T-BUTOXYCARBONYL-O-BENZYL-L-THREONINE

N-TERT-BUTOXACARBONYL-O-BENZYL-L-THREONINE

N-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-(TERT-BUTOXYCARBONYL)-P-THREONINE

N-(TERT-BUTOXYCARBONYL)-O-BENZYL-L-THREONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-THREONINE

N-ALPHA-TERT-BOC-O-BENZYL-L-THREONINE

N-ALPHA-T-BUTOXYCARBONYL-L-THREONINE

N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-THREONINE

N-ALPHA-T-BOC-L-THREONINE

N-ALPHA-T-BOC-O-BENZYL-L-THREONINE

N-BOC-O-BENZYL-L-THREONINE

BOC-L-THREONINE-OH

BOC-L-THR-OH

BOC-L-THREONINE (BZL)

BOC-L-THR(BZL)-OH

BOC-L-THR(BZL)

BOC-O-BENZYL-L-THREONINE

BOC-THR(BZL)

BOC-THREONINE

BOC-THREONINE(BZL)-OH

Boc-O-benzyl-L-threonine≥ 99% (HPLC)

(Tert-Butoxy)Carbonyl Thr(Bzl)-OH

PLIT-017

N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine &gt

(2S,3R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxybutanoicaci

Boc-O-Benzyl-L-threonine USP/EP/BP

N-tert-Butoxycarbonyl-O-benzylthreonine

15260-10-3

C16H23NO5

CH3CHOCH2C6H5CHCOOHNHCOOCCH33

Amino Acid Derivatives

Boc-Amino Acids