Methyl N-(tert-butoxycarbonyl)-L-threoninate

Product Name: Methyl N-(tert-butoxycarbonyl)-L-threoninate
CAS No.: 79479-07-5
Chemical Name: Methyl N-(tert-butoxycarbonyl)-L-threoninate
Synonyms: Boc-L-Thr-OMe;Boc-Thr-OMe-OH;N-BOC-L-threonine methylester;(Tert-Butoxy)Carbonyl Thr-OMe;N-Boc-L-threonine methyl ester, 95%;N-Boc-L-threonine methyl ester, 97.5%;Boc-L-threonine methyl ester≥ 98% (HPLC);N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET&;Methyl N-(tert-butoxycarbonyl)-L-threoninate;Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP
CBNumber: CB3504231
Molecular Formula: C10H19NO5
Formula Weight: 233.26
MOL File: 79479-07-5.mol

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Methyl N-(tert-butoxycarbonyl)-L-threoninate Property

Boiling point:: 206 °C(lit.)
Density: 1.123±0.06 g/cm3(Predicted)
refractive index: n20/D 1.45(lit.)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Dichloromethane (Sparingly), DMF (Sparingly)
form: Viscous Liquid
pka: 11.00±0.46(Predicted)
color: Yellow
Water Solubility: Slightly soluble in water.
Major Application: peptide synthesis
InChI: 1S/C10H19NO5/c1-6(12)7(8(13)15-5)11-9(14)16-10(2,3)4/h6-7,12H,1-5H3,(H,11,14)/t6-,7+/m1/s1
InChIKey: MZMWAPNVRMDIPS-RQJHMYQMSA-N
SMILES: COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O

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Safety

WGK Germany: 3
HS Code: 29241990
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 465658
Product name: N-(tert-Butoxycarbonyl)-L-threonine methyl ester
Purity: 95%
Packaging: 10g
Price: $165
Updated: 2022/05/15

TRC

Product number: B619285
Product name: N-Boc-L-Threoninemethylester
Packaging: 10g
Price: $100
Updated: 2021/12/16

TRC

Product number: B619285
Product name: N-Boc-L-Threoninemethylester
Packaging: 25g
Price: $180
Updated: 2021/12/16

Chem-Impex

Product number: 11887
Product name: Boc-L-threoninemethylester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $33.6
Updated: 2021/12/16

Activate Scientific

Product number: AS21105
Product name: N-(tert-Butoxycarbonyl)-L-threonine Methyl Ester
Purity: 95%
Packaging: 5G
Price: $43
Updated: 2021/12/16

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Methyl N-(tert-butoxycarbonyl)-L-threoninate Chemical Properties,Usage,Production

Chemical Properties

Light yellow transparent oil

Uses

N-Boc-L-threonine methyl ester is used as pharmaceutical intermediates and chemical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2592-18-9

77-78-1

60538-19-4

The general procedure for the synthesis of Boc-D-alanine methyl ester from (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid and dimethyl sulfate was as follows: 1) Synthesis of N-Boc-L-threonine methyl ester: Potassium carbonate (34.7 g, 250 mmol) and dimethyl sulfate (29.3 g, 232 mmol) were sequentially added to a solution of N-Boc-L-threonine (50.0 g, 213 mmol) in acetone (250 mL). The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature in air. Insoluble solids were removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent to afford N-tert-butoxycarbonyl-L-threonine methyl ester as a colorless oil (54.6 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 1.26 (3H, d, J = 6.42 Hz), 1.46 (9H, s), 2.02 (1H, d, J = 5.14 Hz), 3.78 (3H, s), 4.28 (1H, m), 5.29 (1H, m). Mass spectra (FAB) showed molecular ion peak m/z: 234 ([M + H]+).

References

[1] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN108003048, 2018, A. Location in patent: Paragraph 0013

Methyl N-(tert-butoxycarbonyl)-L-threoninate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl N-(tert-butoxycarbonyl)-L-threoninate Suppliers

China 91 Germany 2 India 8 Japan 2 Switzerland 2 United Kingdom 1 United States 10 Global 116

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View Lastest Price from Methyl N-(tert-butoxycarbonyl)-L-threoninate manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Thr-OMe 79479-07-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-16

Career Henan Chemical Co

Product: Methyl N-(tert-butoxycarbonyl)-L-threoninate 79479-07-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

Sichuan Jiaying Lai Technology Co.,LTD

Product: Boc-Thr-OMe 79479-07-5
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-22

79479-07-5, Methyl N-(tert-butoxycarbonyl)-L-threoninateRelated Search:

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methyl (2S,3R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxybutanoate

Methyl N-(tert-butoxycarbonyl)-L-threoninate

N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET&

N-BOC-L-threonine methylester

(2S,3R)-methyl 2-(tert-butoxycarbonylamino)-3-hydroxybutanoate

Boc-L-Thr-OMe

Boc-L-threonine methyl ester≥ 98% (HPLC)

(Tert-Butoxy)Carbonyl Thr-OMe

N-Boc-L-threonine methyl ester, 97.5%

(2S, 3S)-2-Tert-butoxycarbonylaMino-3-hydroxy-butyric acid Methyl ester Boc-Thr-OMe

L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP

Boc-Thr-OMe-OH

<i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<sc>L</sc>-threonine methyl ester

N-Boc-L-threonine methyl ester, 95%

(2S,3R)-Methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoate - [M89142]

79479-07-5

CH3CHOHCHNHCO2CCH33CO2CH3

Threonine

Amino Acid Derivatives

Peptide Synthesis