N-Boc-4-oxo-L-Proline methyl ester

Product Name: N-Boc-4-oxo-L-Proline methyl ester
CAS No.: 102195-80-2
Chemical Name: N-Boc-4-oxo-L-Proline methyl ester
Synonyms: 1-(tert-butyl) 2-methyl (S)-4-oxopyrrolidine-1,2-dicarboxylate;(S)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate;N-Boc-4-oxo-L;CAS:102195-80-2;BOC-4-OXO-PRO-OME;BOC-L-PRO(4-O)-OME;BOC-L-PRO(4-OXO)-OME;BOC-PRO-(4-KETO)-OME;Boc-L-Pro(4-keto)-OMe;BOC-4-OXO-PRO-OME USP/EP/BP
CBNumber: CB3398551
Molecular Formula: C11H17NO5
Formula Weight: 243.26
MOL File: 102195-80-2.mol

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N-Boc-4-oxo-L-Proline methyl ester Property

Melting point:: 35-40°C
alpha: 14 º (C=1 IN CHLOROFORM)
Boiling point:: 333.1±42.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: -3.86±0.40(Predicted)
Appearance: Light yellow to brown Solid
optical activity: [α]22/D +14.0°, c = 1 in chloroform
InChI: InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h8H,5-6H2,1-4H3/t8-/m0/s1
InChIKey: UPBHYYJZVWZCOZ-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C[C@H]1C(OC)=O
CAS DataBase Reference: 102195-80-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-41
Safety Statements: 26-36/37-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H318Causes serious eye damage
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 702498
Product name: N-Boc-4-oxo-L-proline methyl ester
Purity: 97%
Packaging: 1g
Price: $41.4
Updated: 2025/07/31

TRC

Product number: B661225
Product name: (2S)-1-Boc-4-oxo-prolineMethylEster
Packaging: 10g
Price: $635
Updated: 2021/12/16

TRC

Product number: B661225
Product name: (2S)-1-Boc-4-oxo-prolineMethylEster
Packaging: 500mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B661225
Product name: (2S)-1-Boc-4-oxo-prolineMethylEster
Packaging: 1g
Price: $95
Updated: 2021/12/16

Chem-Impex

Product number: 16608
Product name: (S)-4-Oxopyrrolidine-1,2-dicarboxylicacid1-tert-butyl2-methyldiester,≥99%(GC,Chiralpurity)
Purity: ≥99%(GC,Chiralpurity)
Packaging: 5G
Price: $104.83
Updated: 2021/12/16

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N-Boc-4-oxo-L-Proline methyl ester Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

(2S)-1-Boc-4-oxo-proline Methyl Ester (cas# 102195-80-2) is a compound useful in organic synthesis.

Synthesis

74844-91-0

102195-80-2

General procedure for the synthesis of BOC-4-oxo-L-proline methyl ester from N-Boc-trans-4-hydroxy-L-proline methyl ester: (a) To a solution of methyl (2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate (40 g, 157 mmol) in dichloromethane (DCM, 500 mL) was added Days-Martin oxidizer (DMP, 80 g, 189 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 4 h. Upon completion of the reaction, the reaction was quenched with sodium bisulfite (NaHSO3) solution. The reaction mixture was extracted with dichloromethane (DCM) and the organic phase was washed with aqueous sodium bicarbonate (NaHCO3) solution. Concentration of the organic phase afforded the title intermediate (2S)-1-tert-butoxycarbonyl-4-oxopyrrolidine-2-carboxylic acid methyl ester (33 g, 89% yield) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ (ppm) 1.51 (s, 9H), 2.550-2.597 (d, 1H, J = 18.8Hz), 2.876-2.944 (t, 1H, J = 13.6Hz), 3.895 (s, 3H), 3.766-3.895 (m, 1H), 4.696- 4.814 (m, 1H).

References

[1] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 5, p. 740 - 742
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 4, p. 1557 - 1572
[3] Journal of the American Chemical Society, 2016, vol. 138, # 7, p. 2443 - 2453
[4] Angewandte Chemie - International Edition, 2002, vol. 41, # 9, p. 1600 - 1602
[5] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7809 - 7812

N-Boc-4-oxo-L-Proline methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-4-oxo-L-Proline methyl ester Suppliers

Canada 5 China 227 Germany 6 India 5 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 36 Global 287

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View Lastest Price from N-Boc-4-oxo-L-Proline methyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-Boc-4-oxo-L-Proline methyl ester 102195-80-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Career Henan Chemical Co

Product: BOC-4-OXO-PRO-OME 102195-80-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-16

102195-80-2, N-Boc-4-oxo-L-Proline methyl esterRelated Search:

BOC-DL-PRO-OH Methyl N-(tert-butoxycarbonyl)-L-threoninate BOC-TRP(BOC)-OH Boc-Tyr-OtBu Boc-D-Ser(tBu)-OH L-Hydroxyproline L-Proline BOC-SER(TOS)-OCH3 L-Phenylalanine BOC-D-TYR(TBU)-OH N-Boc-trans-4-amino-L-proline methyl ester hydrochloride BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-Boc-4-oxo-L-proline 4-OXO-PROLINE N-Boc-4-oxo-L-Proline methyl ester BOC-L-PRO(4-OXO)-O-BN (2S, 4R)-4-AMINO-1-[T-BUTOXYCARBONYL]PYRROLIDINE-2-ETHYLCARBOXYLATE (2S,4R)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-OXYLATE SALT

Boc-L-Pro(4-keto)-OMe

N-alpha-t-Butyloxycarbonyl-4-oxo-L-proline methyl ester

BOC-PRO-(4-KETO)-OME

BOC-4-OXO-PRO-OME

BOC-4-OXO-L-PROLINE METHYL ESTER

BOC-GAMMA-KETO-L-PROLINE METHYL ESTER

BOC-L-PRO(4-O)-OME

BOC-L-PRO(4-OXO)-OME

(S)-N-ALPHA-TERT-BUTYLOXYCARBONYL-4-OXO-PROLINE METHYL ESTER

N-T-BOC-4-OXO-L-PROLINE METHYL ESTER

N-BOC-4-OXO-L-PROLINE METHYL ESTER

METHYL (2S)-N-BOC-4-OXOPYRROLIDINE-2-CARBOXYLATE

(S)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

(2S)-4-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester

1-BOC-4-OXO-L-PROLINE METHYL ESTER

N-tert-butyloxycarbonyl-4-oxo-L-proline methyl ester

tert-Butyl (2S)-2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate, (2S)-4-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester, 1-tert-Butyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate

1-tert-Butyl 2-methyl(2S)-4-oxopyrrolidine-1,2-dicarboxylate

tert-Butyl(2S)-2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate

Methyl N-Boc-4-keto-prolinate

(2S)-4-Oxo-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-DiMethylethyl) 2-Methyl Ester

(2S)-4-Oxopyrrolidine-1,2-dicarboxylate

1,2-Pyrrolidinedicarboxylicacid, 4-oxo-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-

(2S)-1-Boc-4-o×o-proline Methyl Ester

(S)-1-tert-butyl 2-Methyl 4-o×opyrrolidine-1,2-dicarbo×ylate

(2S)-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-oxopyrrolidine, 4-Oxo-L-proline methyl ester, N-BOC protected

Methyl (2S)-1-Boc-4-oxo-pyrrolidinecarboxylate

(Tert-Butoxy)Carbonyl 4-oxo-Pro-OMe

1-(tert-butyl) 2-methyl (S)-4-oxopyrrolidine-1,2-dicarboxylate

1-tert-Butyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate 97%

N-Boc-4-oxo-L

Boc-4-OXO-Pro-OMe (non-animal)

BOC-4-OXO-PRO-OME USP/EP/BP

N-Boc-4-oxo-L-proline methyl esterQ: What is N-Boc-4-oxo-L-proline methyl ester Q: What is the CAS Number of N-Boc-4-oxo-L-proline methyl ester

102195-80-2 BOC-4-OXO-PRO-OME

(2S)-N-Boc-4-oxo-L-proline methyl ester

(S)-tert-Butyl 2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate

1-(1,1-Dimethylethyl) 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

1-(tert-Butyl) 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate

CAS:102195-80-2

<i>N</i>-Boc-4-oxo-<sc>L</sc>-proline methyl ester

102195-80-2

Boc-Amino Acids and Derivative

Boc-Amino acid series

Amino Acids

Amino Acids & Derivatives

Heterocycles