BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

Product Name: BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
CAS No.: 166410-05-5
Chemical Name: BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
Synonyms: K204;Boc-4-OXO-Pro-OtBu;N-Boc-4-OXO-Pro-OtBu;N-BOC-4-oxo-L-proline t-Butyl Ester;BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;N-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;N-T-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;(2S)-N-Boc-4-oxo-L-proline t-butyl ester;BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER USP/EP/BP;-Di-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate
CBNumber: CB3338629
Molecular Formula: C14H23NO5
Formula Weight: 285.34
MOL File: 166410-05-5.mol

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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Property

Melting point:: 64-67°C
Boiling point:: 366.7±42.0 °C(Predicted)
Density: 1.138±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: solid
pka: -3.86±0.40(Predicted)
color: White to off-white
optical activity: 10.2°(C=1g/100ml CHCL3)
InChI: InChI=1S/C14H23NO5/c1-13(2,3)19-11(17)10-7-9(16)8-15(10)12(18)20-14(4,5)6/h10H,7-8H2,1-6H3/t10-/m0/s1
InChIKey: MPNWQUWKRDADHK-JTQLQIEISA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C[C@H]1C(OC(C)(C)C)=O
LogP: 2.62

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Usbiological

Product number: 265614
Product name: Boc-4-oxo-L-proline tert-butyl ester
Packaging: 250mg
Price: $347
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50584
Product name: Boc-4-oxo-L-proline tert-butyl ester
Packaging: 100g
Price: $400
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34742
Product name: N-Boc-4-oxo-L-prolinetert-butylester
Packaging: 1g
Price: $445
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0011120
Product name: (S)-DI-TERT-BUTYL-4-OXOPYRROLIDINE-1,2-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $500.09
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50584
Product name: Boc-4-oxo-L-proline tert-butyl ester
Packaging: 50g
Price: $250
Updated: 2021/12/16

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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

84348-37-8

75-65-0

166410-05-5

For the synthesis of di-tert-butyl (S)-4-oxopyrrolidine-1,2-dicarboxylate (16c), (S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid (16b, 1.35 g, 5.9 mmol) was dissolved in anhydrous dichloromethane (27 mL) and the solution was cooled to 0 °C. Subsequently, tert-butanol (1.7 mL, 17.7 mmol) and 4-dimethylaminopyridine (DMAP, 72 mg, 0.59 mmol) were sequentially added to the solution. After stirring for 5 min, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl, 1.19 g, 6.2 mmol) was added. The reaction mixture was gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and extracted three times with dichloromethane. The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by fast column chromatography (eluent: n-hexane/ethyl acetate, 8:1) to afford the target product 16c (0.96 g, 57% yield) as a light yellow oil.

References

[1] Tetrahedron, 1995, vol. 51, # 14, p. 4195 - 4212
[2] Patent: WO2017/53990, 2017, A1. Location in patent: Paragraph 00150

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Suppliers

Canada 2 China 117 Germany 4 India 3 Japan 1 United Kingdom 6 United States 20 Global 153

Alfa Aesar

Tel: 400-6106006
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Energy Chemical

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Tetranov Biopharm

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Candia Thamtech Company Limited

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Shanghai Yolne Chemical Co., Ltd.

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Shanghai Hobor Chemical Co., Ltd

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View Lastest Price from BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER manufacturers

Hebei Runbin Biotechnology Co. LTD

Product: BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 166410-05-5
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 20tons
Release date: 2020-09-14

Career Henan Chemical Co

Product: BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 166410-05-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

166410-05-5, BOC-4-OXO-L-PROLINE TERT-BUTYL ESTERRelated Search:

N-Boc-L-lysine methyl ester hydrochloride N-Boc-D-Phenylalaninol N-Boc-D-alaninol N-BOC-L-Prolinal N-Boc-N'-Cbz-L-lysine N-Boc-4-oxo-L-Proline methyl ester 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate BOC-N-ME-DL-PHG-OH BOC-D-ABU-OH N-Boc-4-oxo-L-proline 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID H-PRO-OTBU N-Boc-3-pyrrolidinone BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Methyl 1-Methyl-2-oxopyrrolidine-3-carboxylate 4-OXO-PROLINE BOC-DL-PROLINE ETHYL ESTER N-Boc-5-aminolevulinic acid

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

N-T-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

N-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2- dicarboxylate

(2S) tert-butyl N-(tert-butoxycabonyl)-4-oxoprolinate

Boc-4-OXO-Pro-OtBu

ditert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate

K204

-Di-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate

di-tert-butyl (S)-4-oxopyrrolidine-1,2-dicarboxylate

(2S)-1,2-Bis(tert-butoxycarbonyl)-4-oxopyrrolidine, 4-Oxo-L-proline tert-butyl ester, N-BOC protected

Bis(tert-butyl) (2S)-4-oxopyrrolidine-1,2-dicarboxylate

(2S)-4-Oxo-1,2-pyrrolidinedicarboxylic acid 1,2-bis(1,1-dimethylethyl) ester

N-Boc-4-OXO-Pro-OtBu

(2S) - 1-tert-butoxycarbonyl-4-oxo-proline tert butyl ester

N-BOC-4-oxo-L-proline t-Butyl Ester

1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1,2-bis(1,1-dimethylethyl) ester, (2S)-

(2S)-tert-Butyl-1-tert-butyloxycarbonyl-4-oxo-prolinate

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER USP/EP/BP

(2S)-N-Boc-4-oxo-L-proline t-butyl ester

166410-05-5