N-Boc-N'-Cbz-L-lysine

Product Name: N-Boc-N'-Cbz-L-lysine
CAS No.: 2389-45-9
Chemical Name: N-Boc-N'-Cbz-L-lysine
Synonyms: BOC-LYS(Z);BOC-Z-LYSINE;BOC-LYS(Z)-OH;-Boc-NεBOC-L-LYS(Z)-OH;BOC-LYS(CBZ)-OH;BOC-LYSINE(Z)-OH;Boc-L-Lys(Cbz)-OH;BOC-L-LYSINE(CBZ);BOC-N-E-Z-L-LYSINE
CBNumber: CB3325711
Molecular Formula: C19H28N2O6
Formula Weight: 380.44
MOL File: 2389-45-9.mol

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N-Boc-N'-Cbz-L-lysine Property

Melting point:: 75.0 to 79.0 °C
Boiling point:: 587.0±50.0 °C(Predicted)
Density: 1.176±0.06 g/cm3(Predicted)
refractive index: -8 ° (C=2.5, AcOH)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: almost transparency in Acetic acid
form: powder to crystal
pka: 3.99±0.21(Predicted)
color: White to Almost white
BRN: 1917222
InChI: InChI=1S/C19H28N2O6/c1-19(2,3)27-18(25)21-15(16(22)23)11-7-8-12-20-17(24)26-13-14-9-5-4-6-10-14/h4-6,9-10,15H,7-8,11-13H2,1-3H3,(H,20,24)(H,21,25)(H,22,23)/t15-/m0/s1
InChIKey: BDHUTRNYBGWPBL-HNNXBMFYSA-N
SMILES: C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 2389-45-9(CAS DataBase Reference)
EPA Substance Registry System: N2-tert-Butoxycarbonyl-N6-benzyloxycarbonyl lysine (2389-45-9)

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Safety

Safety Statements: 24/25
WGK Germany: 3
TSCA: Yes
HS Code: 2924 29 70

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53012
Product name: Boc-Lys(Z)-OH
Purity: (cryst) Novabiochem?
Packaging: 25g
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: B8254
Product name: Boc-Lys(Z)-OH
Packaging: 10g
Price: $257
Updated: 2023/06/20

Sigma-Aldrich

Product number: 8.53012
Product name: Boc-Lys(Z)-OH
Purity: (cryst) Novabiochem?
Packaging: 100g
Price: $450
Updated: 2023/01/07

TCI Chemical

Product number: B1632
Product name: Nalpha-(tert-Butoxycarbonyl)-Nepsilon-carbobenzoxy-L-lysine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: B1632
Product name: Nalpha-(tert-Butoxycarbonyl)-Nepsilon-carbobenzoxy-L-lysine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $60
Updated: 2025/07/31

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N-Boc-N'-Cbz-L-lysine Chemical Properties,Usage,Production

Uses

Boc-Lys(Z)-OH, is used in the synthesis of Isodesmosine Chloride (I815050), which is a component of elastin.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

13139-17-8

13734-28-6

2389-45-9

The general procedure for the synthesis of N-Boc-N'-Cbz-L-lysine from N-alpha-Boc-L-lysine and phenylmethoxycarbonylsuccinimide was as follows: to a mixed solution of (2S)-6-amino-2-(tert-butoxycarbonylamino)hexanoic acid (100.00 g, 406.01 mmol, 1.00 equiv) and NaHCO3 (102.33 g 1.22 mol, 3.00 eq.) in a mixed solution of THF (1000 mL) and water (1000 mL) was slowly added CbzOSu (101.19 g, 406.01 mmol, 1.00 eq.) at 0 °C. Subsequently, the reaction mixture was stirred at 30 °C for 16 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 5-6 with 1N HCl and then extracted with ethyl acetate (600 mL x 3). The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product (2S)-6-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)hexanoic acid (142.00 g, 373.26 mmol, 91.9% yield) as a yellow oil.

References

[1] Patent: US2016/96830, 2016, A1. Location in patent: Paragraph 0368-0369

N-Boc-N'-Cbz-L-lysine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-N'-Cbz-L-lysine Suppliers

Americas 1 Belgium 1 Canada 1 CHINA 263 Europe 3 France 1 Germany 7 Hungary 1 India 13 Japan 11 Poland 1 South Korea 1 Switzerland 3 United Kingdom 12 United States 56 Global 375

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View Lastest Price from N-Boc-N'-Cbz-L-lysine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-Boc-N'-Cbz-L-lysine 2389-45-9
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-25

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: N-Boc-N'-Cbz-L-lysine 2389-45-9
Price: US $999.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-22

Chengdu Baishixing Science and Technology Industry Co.,Ltd

Product: N-Boc-N'-Cbz-L-lysine 2389-45-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 2T/month
Release date: 2024-06-13

2389-45-9, N-Boc-N'-Cbz-L-lysineRelated Search:

Iminodibenzyl Poly-L-lysine 6-Aminocaproic acid N-Carbobenzyloxyglycine tert-Butyl carbazate L-Lysine Hexanoic acid Poly(L-lysine hydrobromide) N-Boc-N'-Fmoc-D-lysine N-Boc-N'-Fmoc-L-Lysine Boc-His(Trt)-OH N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-L-Prolinal N-Boc-D-alaninol N-Boc-D-Phenylalaninol

N6-Benzyloxycarbonyl-N2-tert-butoxycarbonyl-L-lysine

2-(tert-Butoxycarbonylamino)-6-(benzoxycarbonylamino)hexanoic acid

BOC-Z-LYSINE

BOC-N-E-Z-L-LYSINE

N-tert-Butoxycarbonyl-Nε-Cbz-L-lysine

NALPHA-BOC-NEPSILON-CBZ-L-LYSINE

NALPHA-BOC-NEPSILON-Z-L-LYSINE

N-ALPHA-T-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE

NALPHA-(TERT-BUTOXYCARBONYL)-NEPSILON-CARBOBENZOXY-L-LYSINE

NALPHA-TERT-BUTOXYCARBONYL-NOMEGA-BENZYLOXYCARBONYL-L-LYSINE

N ALPHA-T-BUTOXYCARBONYL-N OMEGA-BENZYLOXYCARBONYL-L-LYSINE

N-ALPHA-T-BUTOXYCARBONYL-N-EPSILON-CARBOBENZOXY-L-LYSINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE

N-ALPHA-T-BOC-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE

N-ALPHA-T-BOC-N-EPSILON-CBZ-L-LYSINE

NEPSILON-Z-NALPHA-BOC-L-LYSINE

N-(tert-butoxycarbonyl)-N-Z-L-lysine

Nα-Boc-Nε-Z-L-lysine, Nε-Z-Nα-Boc-L-lysine, Nα-Boc-Nε-Cbz-L-lysine

N2-(tert-Butoxycarbonyl)-N6-(benzyloxycarbonyl)-L-lysine

N2-(tert-Butoxycarbonyl)-N6-(benzyloxycarbonyl)lysine

N2-(tert-Butyloxycarbonyl)-N6-(benzyloxycarbonyl)lysine

N6-(Benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-L-lysine

Nα-Boc-Nε-Z-L-Lys-OH

Boc-Lysine(Cbz)-OH

Nα-BOC-Nε-L-lysine

N-Boc-N'-Cbz-L-lysin

Nalpha-Boc-Nepsilon-Cbz-L-lysine Boc-Lys(Z)-OH

N^e-Benzyloxycarbonyl-N^a-Boc-L-lysine, 95%

Nα- (tert-Butoxycarbonyl)-Nε-carbobenzoxy-L-lysine ,99%

(S)-6-(((benzyloxy)carbonyl)aMino)-2-((tert-butoxycarbonyl)aMino)hexanoic acid

-Boc-N&epsilon

Boc-L-Lys(Cbz)-OH

(2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-6-(phenylmethoxycarbonylamino)hexanoic acid

nα-boc-nε-cbz-l-lysine

NALPHA-BOC-NEPSILON-CBZ-L-LYSINE,FREEACID

Nalpha-t-Butoxycarbonyl-Nw-benzyloxycarbonyl-L-lysine

(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoic acid

Boc-L-Lys(Z)-OH (cryst.)

Nα-Boc-Nε-Z-L-lysine99%

Nepsilon-Benzyloxycarbonyl-Nalpha-Boc-L-lysine

Nα-Boc-Nε-Cbz-L-lysine

Nα-Boc-Nε-Z-L-lysine

Nε-Z-Nα-Boc-L-lysine

Boc-Lys(Z)-OH (cryst.)

Butoxycarbonylepsilumcarbobenzoxylysine,98%

N^(alpha)-(tert-Butoxycarbonyl)-N^(epsilum)-carbobenzoxy-L-lysine

NA-T-BOC-N-Epsilon-CBZ-L-Lysine

n2-[(1,1-dimethylethoxy)carbonyl]-n6-[(phenylmethoxy)carbonyl]-l-lysin

na-t-boc-n-epsilon-cbz-l-lysine*freeacid

N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine

Amino acid derives

N-α-Boc-N-δ-Z-L-lysine

BOC-L-LYS(Z)-OH

BOC-L-LYSINE(CBZ)

BOC-N-EPSILON-Z-L-LYSINE

BOC-LYS(CBZ)-OH

BOC-LYSINE(Z)-OH

BOC-LYS(Z)