N-Boc-D-alaninol

Product Name: N-Boc-D-alaninol
CAS No.: 106391-86-0
Chemical Name: N-Boc-D-alaninol
Synonyms: BOC-D-ALA-OL;BOC-D-ALANINOL;tert-butyl (R)-1-hydroxypropan-2-ylcarbamate;(R)-tert-butyl 1-hydroxypropan-2-ylcarbamate;oc-D-Alaninol;Bayer Schering;d-BOC-Alaninol;N-Boc-D-alanino;CAS:106391-86-0;N-BOC-D-ALANINOL
CBNumber: CB4766243
Molecular Formula: C8H17NO3
Formula Weight: 175.23
MOL File: 106391-86-0.mol

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N-Boc-D-alaninol Property

Melting point:: 58-61 °C(lit.)
alpha: 11 º (c=1 in chloroform)
Boiling point:: 276.4±23.0 °C(Predicted)
Density: 1.025±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.11±0.46(Predicted)
color: White to Off-White
optical activity: [α]20/D +11°, c = 1 in chloroform
InChI: InChI=1S/C8H17NO3/c1-6(5-10)9-7(11)12-8(2,3)4/h6,10H,5H2,1-4H3,(H,9,11)/t6-/m1/s1
InChIKey: PDAFIZPRSXHMCO-ZCFIWIBFSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@H](C)CO
CAS DataBase Reference: 106391-86-0(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 10
HS Code: 29051990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 469505
Product name: (R)-2-(Boc-amino)-1-propanol
Purity: 98%, optical purity ee: 98% (GLC)
Packaging: 5g
Price: $79.8
Updated: 2023/01/07

TCI Chemical

Product number: B3261
Product name: N-(tert-Butoxycarbonyl)-D-alaninol
Purity: min. 98.0 %
Packaging: 5G
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: B3261
Product name: N-(tert-Butoxycarbonyl)-D-alaninol
Purity: min. 98.0 %
Packaging: 25G
Price: $96
Updated: 2025/07/31

Usbiological

Product number: 263568
Product name: Boc-D-alaninol
Packaging: 5g
Price: $326
Updated: 2021/12/16

TRC

Product number: B600583
Product name: N-Boc-D-alaninol
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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N-Boc-D-alaninol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Used in the synthesis of antithrombotic nipecotamides.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

35320-23-1

24424-99-5

79069-13-9

GENERAL STEPS: 10 g (133 mmol) of (R)-2-aminopropan-1-ol and 14.8 g (146.5 mmol) of triethylamine were dissolved in 500 mL of tetrahydrofuran and the solution was cooled to 0 °C. A one-time addition of 30 g (133 mmol) of di-tert-butyl dicarbonate was added to the solution with stirring. The reaction mixture was stirred at room temperature for about 18 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in 300 ml of ethyl acetate and washed twice sequentially with 200 ml of water and once with 200 ml of saturated aqueous sodium chloride. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure to give 22 g (94% yield) of the target product N-Boc-L-alaninol as a yellow oil. The structure of the product was confirmed by 1H-NMR (CDCl3): δ4.71 (multiple peaks, 1H), 3.72 (multiple peaks, 1H), 3.59-3.46 (multiple peaks, 2H), 2.86 (multiple peaks, 1H).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556
[2] Patent: US7045545, 2006, B1. Location in patent: Page/Page column 26
[3] Letters in Organic Chemistry, 2010, vol. 7, # 5, p. 353 - 359
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4601 - 4608
[5] Patent: WO2014/159224, 2014, A1. Location in patent: Paragraph 00280

N-Boc-D-alaninol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-D-alaninol Suppliers

Belgium 2 Canada 2 China 281 Europe 1 France 1 Germany 8 India 10 Japan 3 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 44 Global 361

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
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Sichuan Tongsheng Amino acids Co.,Ltd.

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Ark Pharm, Inc.

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Energy Chemical

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View Lastest Price from N-Boc-D-alaninol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Boc-D-alaninol 106391-86-0
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-10-19

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Ala-Ol 106391-86-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-14

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Boc-D-Ala-Ol 106391-86-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-02

106391-86-0, N-Boc-D-alaninolRelated Search:

1-Propanol tert-Butyl acetate Cyromazine tert-Butyl peroxyacetate tert-Butanol (R)-(-)-2-Amino-1-propanol EC 2.6.1.2 (S)-(-)-2-Methyl-1-butanol N-Carbobenzyloxyglycine N-Boc-N'-Cbz-L-lysine BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-L-Prolinal N-Boc-D-Phenylalaninol N-Boc-L-lysine methyl ester hydrochloride 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate BOC-N-ME-DL-PHG-OH BOC-D-ABU-OH Carbonyl iron powder

(R)-tert-butyl 1-hydroxypropan-2-ylcarbamate

REF DUPL: Boc-D-Alaninol

(R)-2-(Boc-amino)-1-propanol,(R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol, N-Boc-D-alaninol

Bayer Schering

(2R)-2-Aminopropan-1-ol, N-BOC protected

tert-Butyl [(2R)-1-hydroxyprop-2-yl]carbamate, D-Alaninol, N-BOC protected

(R)-2-(Boc-amino)-1-propanol 98%, optical purity ee: 98% (GLC)

N-Boc-D-alaninol,99%e.e.

Boc-D-Alaninol≥ 98% (GC)

N-boc-d-alanine alcohol

BOC-(R)-2-AMINO-1-PROPANOL

BOC-D-ALA-OL

BOC-D-ALANINOL

2R-BOC-AMINO-1-PROPANOL

N-T-BOC-D-ALANINOL

N-T-BUTOXYCARBONYL-D-ALANINOL

(R)-(+)-2-(BOC-AMINO)-1-PROPANOL

(R)-2-(BOC-AMINO)-1-PROPANOL

(R)-2-(TERT-BUTYLOXYCARBONYL-AMINO)-1-PROPANOL

(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-1-PROPANOL

N-ALPHA-T-BOC-D-ALANINOL

N-ALPHA-TERT-BUTYLOXYCARBONYL-D-ALANINOL

N-BOC-D-ALANINOL

d-BOC-Alaninol

(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-1-P ROPANOL, 98% (98% EE/GLC)

Carbamic acid, [(1R)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)

N-TERT-BOC-D-ALANINOL

N-tert-Butoxycarbonyl-D-alaninol

tert-butyl (R)-1-hydroxypropan-2-ylcarbamate

N-Boc-D-alaninol, 98%, ee 98%

(R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol, N-Boc-D-alaninol

tert-butyl N-[(1R)-2-hydroxy-1-methyl-ethyl]carbamate

tert-butyl N-[(2R)-1-hydroxypropan-2-yl]carbamate

N-Boc-D-alanino

-(+)-2-(BOC-amino)-1-propanol

Carbamic acid, N-[(1R)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester

N-Boc-D-alaninol USP/EP/BP

N-Boc-D-propanol

oc-D-Alaninol

1,1-Dimethylethyl?N-[(1R)-2-hydroxy-1-methylethyl]carbamate

CAS:106391-86-0

(<i>R</i>)-2-(Boc-amino)-1-propanol

BOC-D-alaninol - [A7973]

106391-86-0

32449-92-0

Amino Acid Derivatives

Amino Alcohols

Peptide Synthesis

Specialty Synthesis

Amino Alcohols

Boc-Amino acid series

Amino Acids

N-BOC