1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate

Uses

Product Name: 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
CAS No.: 146256-98-6
Chemical Name: 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
Synonyms: Ethyl 1-Boc-4-Oxopyrrolidine-3-carboxylate;1-Bo;EOPC;Ethyl 1-Boc-4-Oxopyrrolid...;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate;EOPC Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(EOPC);Ethyl -N-Boc-4-Oxopyrrolidine-3-carboxylate;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate USP/EP/BP;N-BOC-4-oxo-3-pyrrolidinecarboxylic acid ethyl ester
CBNumber: CB91459653
Molecular Formula: C12H19NO5
Formula Weight: 257.28
MOL File: 146256-98-6.mol

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1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Property

Melting point:: 54.0 to 59.0 °C
Boiling point:: 120°C/0.4mmHg(lit.)
Density: 1.182
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder to crystal
pka: 11.19±0.20(Predicted)
color: White to Light yellow
InChI: InChI=1S/C12H19NO5/c1-5-17-10(15)8-6-13(7-9(8)14)11(16)18-12(2,3)4/h8H,5-7H2,1-4H3
InChIKey: CWRFSVAKVCSOPI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C(C(OCC)=O)C1

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Safety

Risk Statements: 36/38
Safety Statements: 36
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4658
Product name: 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
Purity: >97.0%(HPLC)(N)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: B4658
Product name: 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
Purity: >97.0%(HPLC)(N)
Packaging: 5g
Price: $95
Updated: 2025/07/31

TRC

Product number: B699373
Product name: 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

TRC

Product number: B699373
Product name: 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J98928
Product name: EthylN-Boc-4-Oxopyrrolidine-3-carboxylate
Packaging: 25g
Price: $60
Updated: 2021/12/16

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1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Chemical Properties,Usage,Production

Uses

1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate is a useful research chemical.

Chemical Properties

White to slightly yellow crystalline powd

Synthesis

541-41-3

101385-93-7

146256-98-6

1-tert-butoxycarbonyl-3-pyrrolidone (120 g) and N,N-dimethylformamide (DMF, 600 mL) were added to a 1000 mL four-neck flask and the reaction system was cooled to 0-5°C and stirred. At this temperature, sodium hydride (26 g) was added in batches, followed by the slow dropwise addition of ethyl chloroformate (70.5 g) for a controlled dropwise time of about 40 minutes. After the dropwise addition was completed, the reaction was kept at 0-5°C and continued to be stirred for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction was quenched by slowly adding ice water (3 L). The pH of the reaction solution was adjusted to 7 with dilute hydrochloric acid and subsequently extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the intermediate 1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate in 85% yield.

References

[1] Patent: CN106905325, 2017, A. Location in patent: Paragraph 0030-0032

1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Suppliers

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View Lastest Price from 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate 146256-98-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate 146256-98-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: >98%
Supply Ability: 200kg
Release date: 2019-08-30

146256-98-6, 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylateRelated Search:

BOC-D-ABU-OH BOC-N-ME-DL-PHG-OH N-Boc-L-lysine methyl ester hydrochloride N-Boc-D-Phenylalaninol N-Boc-D-alaninol N-BOC-L-Prolinal BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-Boc-N'-Cbz-L-lysine N-(2-Hydroxyethyl)-2-pyrrolidone 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate 4-Oxo-1,3-pyrrolidinedicarboxylicaciddiethylester Ethyl 1-Boc-3-pyrrolidinecarboxylate N-Boc-3-pyrrolidinone Methyl 1-Boc-3-pyrrolidinecarboxylate Methyl 1-Methyl-2-oxopyrrolidine-3-carboxylate

Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate

4-Oxopyrrolidine-1,3-dicarboxylic Acid 1-tert-Butyl 3-Ethyl Ester

Ethyl 1-tert-butoxycarbonyl-3-oxopyrrolidine-4-carboxylate 97%

Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(EOPC)

Ethyl 1-tert-butyloxycarbonyl-4-oxopyrrolidine-3-carboxylate

Ethyl 1-Boc-4-Oxopyrrolid...

1,3-Pyrrolidinedicarboxylic acid 4-oxo-1-(1,1-dimethylethyl) 3-ethyl ester

Ethyl 1-Boc-4-Oxopyrrolidine-3-carboxylate

1-Boc-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester

1-(tert-Butoxycarbonyl)pyrrolidin-3-one-4-carboxylic acid ethyl ester

Ethyl 1-tert-butoxycarbonyl-3-oxopyrrolidine-4-carboxylate

Ethyl -<i>N</i>-Boc-4-Oxopyrrolidine-3-carboxylate

N1-BOC-4-Oxo-3-pyrrolidinecarboxylic acid ethyl ester

1-<i>tert</i>-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate

EOPC Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate

1-O-tert-butyl 3-O-ethyl 4-oxopyrrolidine-1,3-dicarboxylate

1-Tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-Dicarboxylate(WX618157)

1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate≥ 98%(HPLC)

O1-tert-Butyl O3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate

1-Bo

1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate &gt

Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate USP/EP/BP

1-(1,1-Dimethylethyl) 3-ethyl 4-oxo-1,3-pyrrolidinedicarboxylate

1-(tert-Butyl) 3-ethyl 4-oxo-1,3-pyrrolidinedicarboxylate

EOPC

N-BOC-4-oxo-3-pyrrolidinecarboxylic acid ethyl ester

4-oxo-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) 3-ethyl ester

146256-98-6

CHIRAL CHEMICALS

Carbonyl Compounds

Amino Acids and Derivatives