ChemicalBook > CAS DataBase List > 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
Uses- Product Name
- 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
- CAS No.
- 146256-98-6
- Chemical Name
- 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate
- Synonyms
- Ethyl 1-Boc-4-Oxopyrrolidine-3-carboxylate;1-Bo;EOPC;Ethyl 1-Boc-4-Oxopyrrolid...;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate;EOPC Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate(EOPC);Ethyl -N-Boc-4-Oxopyrrolidine-3-carboxylate;Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate USP/EP/BP;N-BOC-4-oxo-3-pyrrolidinecarboxylic acid ethyl ester
- CBNumber
- CB91459653
- Molecular Formula
- C12H19NO5
- Formula Weight
- 257.28
- MOL File
- 146256-98-6.mol
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1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Property
- Melting point:
- 54.0 to 59.0 °C
- Boiling point:
- 120°C/0.4mmHg(lit.)
- Density
- 1.182
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- powder to crystal
- pka
- 11.19±0.20(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C12H19NO5/c1-5-17-10(15)8-6-13(7-9(8)14)11(16)18-12(2,3)4/h8H,5-7H2,1-4H3
- InChIKey
- CWRFSVAKVCSOPI-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(=O)C(C(OCC)=O)C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B4658
- Product name
- 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B4658
- Product name
- 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
- Purity
- >97.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
TRC
- Product number
- B699373
- Product name
- 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
TRC
- Product number
- B699373
- Product name
- 1-tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-dicarboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- J98928
- Product name
- EthylN-Boc-4-Oxopyrrolidine-3-carboxylate
- Packaging
- 25g
- Price
- $60
- Updated
- 2021/12/16
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1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Chemical Properties,Usage,Production
Uses
1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate is a useful research chemical.
Chemical Properties
White to slightly yellow crystalline powd
Synthesis
541-41-3
101385-93-7
146256-98-6
1-tert-butoxycarbonyl-3-pyrrolidone (120 g) and N,N-dimethylformamide (DMF, 600 mL) were added to a 1000 mL four-neck flask and the reaction system was cooled to 0-5°C and stirred. At this temperature, sodium hydride (26 g) was added in batches, followed by the slow dropwise addition of ethyl chloroformate (70.5 g) for a controlled dropwise time of about 40 minutes. After the dropwise addition was completed, the reaction was kept at 0-5°C and continued to be stirred for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction was quenched by slowly adding ice water (3 L). The pH of the reaction solution was adjusted to 7 with dilute hydrochloric acid and subsequently extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the intermediate 1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate in 85% yield.
References
[1] Patent: CN106905325, 2017, A. Location in patent: Paragraph 0030-0032
1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate 146256-98-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate 146256-98-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- >98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30
146256-98-6, 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylateRelated Search:
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