N-Boc-3-pyrrolidinone

Product Name: N-Boc-3-pyrrolidinone
CAS No.: 101385-93-7
Chemical Name: N-Boc-3-pyrrolidinone
Synonyms: TERT-BUTYL 3-OXOPYRROLIDINE-1-CARBOXYLATE;tert-butyl 2-oxopyrrolidine-1-carboxylate;1-tert-Butoxycarbonyl-3-pyrrolidone;3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-3-pyrroL;BOC-3-PYRROLIDINONE;1-BOC-3-PYRROLIDONE;N-Boc-3-pyrolidinone;N-BOC-3-Pyrrolodinone;1-BOC-3-PYRROLIDINONE
CBNumber: CB2740029
Molecular Formula: C9H15NO3
Formula Weight: 185.22
MOL File: 101385-93-7.mol

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N-Boc-3-pyrrolidinone Property

Melting point:: 34-38 °C (lit.)
Boiling point:: 270.9±33.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Dichloromethane, Ethyl Acetate, Methanol
pka: -1.79±0.20(Predicted)
form: Low Melting Solid
color: White to yellow to orange
Water Solubility: Insoluble in water.
InChI: InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h4-6H2,1-3H3
InChIKey: JSOMVCDXPUXKIC-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)C1
CAS DataBase Reference: 101385-93-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38-20/21/22
Safety Statements: 26-36/37/39-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 637564
Product name: N-Boc-3-pyrrolidinone
Purity: 97%
Packaging: 1g
Price: $31.24
Updated: 2025/07/31

Sigma-Aldrich

Product number: 637564
Product name: N-Boc-3-pyrrolidinone
Purity: 97%
Packaging: 10g
Price: $278.15
Updated: 2025/07/31

TCI Chemical

Product number: B3589
Product name: 1-tert-Butoxycarbonyl-3-pyrrolidone
Purity: >95.0%(GC)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B3589
Product name: 1-tert-Butoxycarbonyl-3-pyrrolidone
Purity: >95.0%(GC)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TRC

Product number: B665950
Product name: 1-Boc-3-pyrrolidinone
Packaging: 10g
Price: $340
Updated: 2021/12/16

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N-Boc-3-pyrrolidinone Chemical Properties,Usage,Production

Description

N-Boc-3-pyrrolidinone is an organic compound insoluble in water. It is a starting material for the synthesis of spirocyclic tetrahydrofuran and is also used in studies related to the preparation of 5-membered heterocyclic secondary alcohols with carrot as a biocatalyst^[1].

Chemical Properties

Brown Oil

Uses

In the Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins 1-Boc-3-pyrrolidinone is used.

Uses

Used in a study of asymmetric hydrogen-transfer bioreduction of ketones with Leifsonia alcohol dehydrogenase.

Synthesis

83220-73-9

101385-93-7

General procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from 1-tert-butoxycarbonyl-3-pyrrolidinone: To a dichloromethane (20 mL) solution of oxalyl chloride (2.8 mL, 32.4 mmol) a dichloromethane (40 mL) solution of dimethylsulfoxide (DMSO, 4.6 mL, 64.8 mmol) was slowly added at -78 °C, and subsequently the reaction mixture was stirred at -15 °C for 5 min. Next, a dichloromethane (60 mL) solution of N-Boc-3-pyrrolidinol (4.04 g, 21.6 mmol) was added at -78°C and stirring was continued for 2 hours at this temperature. Subsequently, triethylamine (15 mL, 108 mmol) was added to the reaction mixture and stirred at -78 °C for 1 hour. After that, the reaction mixture was slowly warmed to room temperature and stirring was continued for 2 hours at room temperature. After completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and diluted with ethyl acetate. The organic layer was washed sequentially with saturated sodium bicarbonate solution and saturated saline. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 1-tert-butoxycarbonyl-3-pyrrolidinone (4 g, 100% yield), which could be used for subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.79-3.75 (m, 4H), 2.58 (t, J = 8.0 Hz, 2H), 1.47 (s, 9H).

References

[1] NAIRA VIEIRA MACHADO á. O. Enantioselective reduction of heterocyclic ketones with low level of asymmetry using carrots[J]. Biocatalysis and Biotransformation, 2021. DOI:10.1080/10242422.2021.1879795.

N-Boc-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-3-pyrrolidinone Suppliers

Americas 1 Belgium 3 Canada 4 CHINA 445 Europe 3 France 1 Germany 5 India 26 Japan 3 Poland 1 Sweden 1 Switzerland 1 The Netherlands 1 United Kingdom 20 United States 71 Global 586

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from N-Boc-3-pyrrolidinone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Boc-3-pyrrolidinone 101385-93-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Henan Aochuang Chemical Co.,Ltd.

Product: N-Boc-3-pyrrolidinone 101385-93-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-23

Nanjing Fred Technology Co., Ltd

Product: N-Boc-3-pyrrolidinone 101385-93-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

101385-93-7, N-Boc-3-pyrrolidinoneRelated Search:

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N-BOC-3-PYRROLIDINONE 98%

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<i>N</i>-Boc-3-pyrrolidinone

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101385-93-7

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Carbonyl Compounds