1-Boc-3-cyano-4-oxopyrrolidine

Product Name: 1-Boc-3-cyano-4-oxopyrrolidine
CAS No.: 175463-32-8
Chemical Name: 1-Boc-3-cyano-4-oxopyrrolidine
Synonyms: CAS:175463-32-8;1-N-Boc-3-Cyano-Pyr;1-Boc-3-cyano-4-oxopyrrol...;N-Boc-3-cyano-pyrrolid-4-one;1-N-BOC-3-CYANO-PYRROLIDONE-4;1-Boc-3-Cyano-4-pyrrolidinone;N-BOC-3-CYANO-4-PYRROLIDINONE;1-N-BOC-3-CYANO-PYRROLID-4-ONE;1-BOC-3-CYANO-4-OXOPYRROLIDINE;1-BOC-3-cyan-4-ketopyrrolidine
CBNumber: CB0271905
Molecular Formula: C10H14N2O3
Formula Weight: 210.23
MOL File: 175463-32-8.mol

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1-Boc-3-cyano-4-oxopyrrolidine Property

Melting point:: 160-167°C
Boiling point:: 360.7±42.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: -4.24±0.40(Predicted)
color: White to Light yellow
LogP: 1.11 at 20℃
CAS DataBase Reference: 175463-32-8(CAS DataBase Reference)

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 9-26-36/37
RIDADR: UN3439
HazardClass: 6.1
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4761
Product name: 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
Purity: >98.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B4761
Product name: 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
Purity: >98.0%(GC)
Packaging: 5g
Price: $138
Updated: 2025/07/31

TRC

Product number: B646190
Product name: 1-Boc-3-cyano-4-pyrrolidinone
Packaging: 25g
Price: $800
Updated: 2021/12/16

Chem-Impex

Product number: 43860
Product name: 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 5G
Price: $161.78
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140746
Product name: tert-Butyl 3-cyano-4-oxopyrrolidine-1-carboxylate
Packaging: 50g
Price: $170
Updated: 2021/12/16

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1-Boc-3-cyano-4-oxopyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

1-Boc-3-cyano-4-pyrrolidinone is used in the synthesis of new napthyridone antibacterials. Also used in the synthesis of gemifloxacin derivatives containing benzyloxime moiety.

Synthesis

266353-18-8

175463-32-8

General procedure for the synthesis of 1-Boc-3-cyano-4-pyrrolidinone from ethyl 2-(BOC-(2-cyanoethyl)amino)acetate: 2-(BOC-(2-cyanoethyl)amino)ethyl acetate (16.5 g), an oil, was dissolved in 50 mL of anhydrous ethanol. The solution was slowly added dropwise to 100 mL of anhydrous ethanol solution containing 4 g (0.17 mol) of sodium metal under heated reflux conditions and the reaction was continued at reflux for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of water and the aqueous layer was subsequently washed with ethyl acetate (30 mL x 2). The pH of the aqueous layer was adjusted to 4 with 1 mol/L hydrochloric acid and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated to about 20 mL, filtered, and the filter cake was washed with a small amount of ethyl acetate and dried to give 16.5 g of white solid 1-Boc-3-cyano-4-pyrrolidinone in 68% yield.

References

[1] Archiv der Pharmazie, 2011, vol. 344, # 8, p. 523 - 529
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 5498 - 5506
[3] Patent: CN105585518, 2016, A. Location in patent: Paragraph 0024; 0026
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3584 - 3593
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4399 - 4403

1-Boc-3-cyano-4-oxopyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-cyano-4-oxopyrrolidine Suppliers

Americas 1 Belgium 2 Canada 1 China 181 Europe 1 France 2 Germany 6 India 5 Japan 2 United Kingdom 13 United States 41 Global 255

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View Lastest Price from 1-Boc-3-cyano-4-oxopyrrolidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: tert-Butyl 3-cyano-4-oxopyrrolidine-1-carboxylate 175463-32-8
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

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CAS:175463-32-8

175463-32-8

C10H14N2O3

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline