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1-Boc-3-cyano-4-oxopyrrolidine

Product Name
1-Boc-3-cyano-4-oxopyrrolidine
CAS No.
175463-32-8
Chemical Name
1-Boc-3-cyano-4-oxopyrrolidine
Synonyms
CAS:175463-32-8;1-N-Boc-3-Cyano-Pyr;1-Boc-3-cyano-4-oxopyrrol...;N-Boc-3-cyano-pyrrolid-4-one;1-N-BOC-3-CYANO-PYRROLIDONE-4;1-Boc-3-Cyano-4-pyrrolidinone;N-BOC-3-CYANO-4-PYRROLIDINONE;1-N-BOC-3-CYANO-PYRROLID-4-ONE;1-BOC-3-CYANO-4-OXOPYRROLIDINE;1-BOC-3-cyan-4-ketopyrrolidine
CBNumber
CB0271905
Molecular Formula
C10H14N2O3
Formula Weight
210.23
MOL File
175463-32-8.mol
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1-Boc-3-cyano-4-oxopyrrolidine Property

Melting point:
160-167°C
Boiling point:
360.7±42.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-4.24±0.40(Predicted)
color 
White to Light yellow
LogP
1.11 at 20℃
CAS DataBase Reference
175463-32-8(CAS DataBase Reference)
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Safety

Risk Statements 
20/21/22-36/37/38
Safety Statements 
9-26-36/37
RIDADR 
UN3439
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4761
Product name
1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
Purity
>98.0%(GC)
Packaging
1g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
B4761
Product name
1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
Purity
>98.0%(GC)
Packaging
5g
Price
$138
Updated
2025/07/31
TRC
Product number
B646190
Product name
1-Boc-3-cyano-4-pyrrolidinone
Packaging
25g
Price
$800
Updated
2021/12/16
Chem-Impex
Product number
43860
Product name
1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone,≥98%(GC)
Purity
≥98%(GC)
Packaging
5G
Price
$161.78
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140746
Product name
tert-Butyl 3-cyano-4-oxopyrrolidine-1-carboxylate
Packaging
50g
Price
$170
Updated
2021/12/16
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1-Boc-3-cyano-4-oxopyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

1-Boc-3-cyano-4-pyrrolidinone is used in the synthesis of new napthyridone antibacterials. Also used in the synthesis of gemifloxacin derivatives containing benzyloxime moiety.

Synthesis

266353-18-8

175463-32-8

General procedure for the synthesis of 1-Boc-3-cyano-4-pyrrolidinone from ethyl 2-(BOC-(2-cyanoethyl)amino)acetate: 2-(BOC-(2-cyanoethyl)amino)ethyl acetate (16.5 g), an oil, was dissolved in 50 mL of anhydrous ethanol. The solution was slowly added dropwise to 100 mL of anhydrous ethanol solution containing 4 g (0.17 mol) of sodium metal under heated reflux conditions and the reaction was continued at reflux for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of water and the aqueous layer was subsequently washed with ethyl acetate (30 mL x 2). The pH of the aqueous layer was adjusted to 4 with 1 mol/L hydrochloric acid and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated to about 20 mL, filtered, and the filter cake was washed with a small amount of ethyl acetate and dried to give 16.5 g of white solid 1-Boc-3-cyano-4-pyrrolidinone in 68% yield.

References

[1] Archiv der Pharmazie, 2011, vol. 344, # 8, p. 523 - 529
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 5498 - 5506
[3] Patent: CN105585518, 2016, A. Location in patent: Paragraph 0024; 0026
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3584 - 3593
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4399 - 4403

1-Boc-3-cyano-4-oxopyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-cyano-4-oxopyrrolidine Suppliers

Americas 1 Belgium 2 Canada 1 China 181 Europe 1 France 2 Germany 6 India 5 Japan 2 United Kingdom 13 United States 41 Global 255
Alkemi BVBA
Tel
--
Fax
--
Email
nfo@alkemi.be
Country
Belgium
ProdList
2201
Advantage
58
TCI EUROPE N.V.
Tel
--
Fax
--
Email
sales@tcieurope.be
Country
Belgium
ProdList
2200
Advantage
66
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View Lastest Price from 1-Boc-3-cyano-4-oxopyrrolidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
tert-Butyl 3-cyano-4-oxopyrrolidine-1-carboxylate 175463-32-8
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-05

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