1-Boc-3-cyano-4-oxopyrrolidine
- Product Name
- 1-Boc-3-cyano-4-oxopyrrolidine
- CAS No.
- 175463-32-8
- Chemical Name
- 1-Boc-3-cyano-4-oxopyrrolidine
- Synonyms
- CAS:175463-32-8;1-N-Boc-3-Cyano-Pyr;1-Boc-3-cyano-4-oxopyrrol...;N-Boc-3-cyano-pyrrolid-4-one;1-N-BOC-3-CYANO-PYRROLIDONE-4;1-Boc-3-Cyano-4-pyrrolidinone;N-BOC-3-CYANO-4-PYRROLIDINONE;1-N-BOC-3-CYANO-PYRROLID-4-ONE;1-BOC-3-CYANO-4-OXOPYRROLIDINE;1-BOC-3-cyan-4-ketopyrrolidine
- CBNumber
- CB0271905
- Molecular Formula
- C10H14N2O3
- Formula Weight
- 210.23
- MOL File
- 175463-32-8.mol
1-Boc-3-cyano-4-oxopyrrolidine Property
- Melting point:
- 160-167°C
- Boiling point:
- 360.7±42.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -4.24±0.40(Predicted)
- color
- White to Light yellow
- LogP
- 1.11 at 20℃
- CAS DataBase Reference
- 175463-32-8(CAS DataBase Reference)
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 9-26-36/37
- RIDADR
- UN3439
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B4761
- Product name
- 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- B4761
- Product name
- 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- B646190
- Product name
- 1-Boc-3-cyano-4-pyrrolidinone
- Packaging
- 25g
- Price
- $800
- Updated
- 2021/12/16
- Product number
- 011526
- Product name
- 1-N-Boc-3-Cyano-pyrrolid-4-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 011526
- Product name
- 1-N-Boc-3-Cyano-pyrrolid-4-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
1-Boc-3-cyano-4-oxopyrrolidine Chemical Properties,Usage,Production
Chemical Properties
Light yellow powder
Uses
1-Boc-3-cyano-4-pyrrolidinone is used in the synthesis of new napthyridone antibacterials. Also used in the synthesis of gemifloxacin derivatives containing benzyloxime moiety.
Synthesis
266353-18-8
175463-32-8
General procedure for the synthesis of 1-Boc-3-cyano-4-pyrrolidinone from ethyl 2-(BOC-(2-cyanoethyl)amino)acetate: 2-(BOC-(2-cyanoethyl)amino)ethyl acetate (16.5 g), an oil, was dissolved in 50 mL of anhydrous ethanol. The solution was slowly added dropwise to 100 mL of anhydrous ethanol solution containing 4 g (0.17 mol) of sodium metal under heated reflux conditions and the reaction was continued at reflux for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of water and the aqueous layer was subsequently washed with ethyl acetate (30 mL x 2). The pH of the aqueous layer was adjusted to 4 with 1 mol/L hydrochloric acid and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated to about 20 mL, filtered, and the filter cake was washed with a small amount of ethyl acetate and dried to give 16.5 g of white solid 1-Boc-3-cyano-4-pyrrolidinone in 68% yield.
References
[1] Archiv der Pharmazie, 2011, vol. 344, # 8, p. 523 - 529
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 5498 - 5506
[3] Patent: CN105585518, 2016, A. Location in patent: Paragraph 0024; 0026
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3584 - 3593
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4399 - 4403
1-Boc-3-cyano-4-oxopyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-3-cyano-4-oxopyrrolidine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 1-Boc-3-cyano-4-oxopyrrolidine manufacturers
- Product
- tert-Butyl 3-cyano-4-oxopyrrolidine-1-carboxylate 175463-32-8
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-Boc-3-cyano-4-oxopyrrolidine 175463-32-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05