1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID

Product Name: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
CAS No.: 876317-19-0
Chemical Name: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
Synonyms: N-Boc-4-oxo-DL-Proline;BOC- 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;1-Boc-4-oxo-2-pyrrolidinecarboxylic acid;N-BOC-4-oxopyrrolidine-2-carboxylic acid;4-OXOPYRROLIDINE-2-CARBOXYLIC ACID, N-BOC PROTECTED;4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid;1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid 95%
CBNumber: CB7103726
Molecular Formula: C10H15NO5
Formula Weight: 229.23
MOL File: 876317-19-0.mol

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1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Property

Melting point:: 155 °C
Boiling point:: 390.8±42.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: solid
pka: 3.85±0.20(Predicted)
color: Brown

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB139726
Product name: 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139726
Product name: 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
Packaging: 250mg
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-JF
Product name: 1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid
Packaging: 1g
Price: $152
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139726
Product name: 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
Packaging: 500mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139726
Product name: 1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
Packaging: 1g
Price: $250
Updated: 2021/12/16

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1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

1-[(tert-Butoxy)carbonyl]-4-oxopyrrolidine-2-carboxylic Acid may be useful in the preparation of pyridinylethynyldihydropyrroloquinazolinone derivatives and analogs for use as metabotropic glutamate receptor 5 modulators.

Synthesis

40350-82-1

876317-19-0

General procedure for the synthesis of 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid from 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid: 1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (178 g, 0.77 mol) was dissolved in dichloromethane (2.0 L), trichloroisocyanuric acid (178.89 g, 0.77 mol), followed by 2,2,6,6-tetramethylpiperidine oxide (6.05 g, 0.0385 mol). The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction was quenched with water and the insoluble material was removed by filtration. The aqueous phase was extracted several times with dichloromethane, all organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated to dryness under vacuum to give 1-tert-butyl-4-oxopyrrolidine-2-carboxylic acid (180 g) in 100% yield.

References

[1] Patent: CN105503891, 2016, A. Location in patent: Paragraph 0008; 0016

1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID 876317-19-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Career Henan Chemical Co

Product: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID 876317-19-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-23

876317-19-0, 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACIDRelated Search:

Polyvinylpyrrolidone 4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER (S)-1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID N-Boc-4-oxo-L-Proline methyl ester (R)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER (R)-4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER BOC-L-PRO(4-OXO)-O-BN

4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%

BOC- 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID

(2S)-1-TERT-BUTYL HYDROGEN 4-OXOPYRROLIDINE-1,2-DICARBOXYLATE

4-OXOPYRROLIDINE-2-CARBOXYLIC ACID, N-BOC PROTECTED

4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID

1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid 95%

1-tert-(Butoxycarbonyl)pyrrolidin-4-one-2-carboxylic acid

1-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxopyrrolidine-2-carboxylic acid

N-Boc-4-oxo-DL-Proline

1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-dimethylethyl) ester

1-Boc-4-oxo-2-pyrrolidinecarboxylic acid

N-BOC-4-oxopyrrolidine-2-carboxylic acid

876317-19-0