ChemicalBook > CAS DataBase List > N-Boc-D-alaninol

N-Boc-D-alaninol

Product Name
N-Boc-D-alaninol
CAS No.
106391-86-0
Chemical Name
N-Boc-D-alaninol
Synonyms
BOC-D-ALA-OL;BOC-D-ALANINOL;tert-butyl (R)-1-hydroxypropan-2-ylcarbamate;(R)-tert-butyl 1-hydroxypropan-2-ylcarbamate;oc-D-Alaninol;Bayer Schering;d-BOC-Alaninol;N-Boc-D-alanino;CAS:106391-86-0;N-BOC-D-ALANINOL
CBNumber
CB4766243
Molecular Formula
C8H17NO3
Formula Weight
175.23
MOL File
106391-86-0.mol
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N-Boc-D-alaninol Property

Melting point:
58-61 °C(lit.)
alpha 
11 º (c=1 in chloroform)
Boiling point:
276.4±23.0 °C(Predicted)
Density 
1.025±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
12.11±0.46(Predicted)
color 
White to Off-White
optical activity
[α]20/D +11°, c = 1 in chloroform
InChI
InChI=1S/C8H17NO3/c1-6(5-10)9-7(11)12-8(2,3)4/h6,10H,5H2,1-4H3,(H,9,11)/t6-/m1/s1
InChIKey
PDAFIZPRSXHMCO-ZCFIWIBFSA-N
SMILES
C(OC(C)(C)C)(=O)N[C@H](C)CO
CAS DataBase Reference
106391-86-0(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
10
HS Code 
29051990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
469505
Product name
(R)-2-(Boc-amino)-1-propanol
Purity
98%, optical purity ee: 98% (GLC)
Packaging
5g
Price
$79.8
Updated
2023/01/07
TCI Chemical
Product number
B3261
Product name
N-(tert-Butoxycarbonyl)-D-alaninol
Purity
min. 98.0 %
Packaging
5G
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
B3261
Product name
N-(tert-Butoxycarbonyl)-D-alaninol
Purity
min. 98.0 %
Packaging
25G
Price
$96
Updated
2025/07/31
Usbiological
Product number
263568
Product name
Boc-D-alaninol
Packaging
5g
Price
$326
Updated
2021/12/16
TRC
Product number
B600583
Product name
N-Boc-D-alaninol
Packaging
250mg
Price
$45
Updated
2021/12/16
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N-Boc-D-alaninol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Used in the synthesis of antithrombotic nipecotamides.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

35320-23-1

24424-99-5

79069-13-9

GENERAL STEPS: 10 g (133 mmol) of (R)-2-aminopropan-1-ol and 14.8 g (146.5 mmol) of triethylamine were dissolved in 500 mL of tetrahydrofuran and the solution was cooled to 0 °C. A one-time addition of 30 g (133 mmol) of di-tert-butyl dicarbonate was added to the solution with stirring. The reaction mixture was stirred at room temperature for about 18 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in 300 ml of ethyl acetate and washed twice sequentially with 200 ml of water and once with 200 ml of saturated aqueous sodium chloride. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure to give 22 g (94% yield) of the target product N-Boc-L-alaninol as a yellow oil. The structure of the product was confirmed by 1H-NMR (CDCl3): δ4.71 (multiple peaks, 1H), 3.72 (multiple peaks, 1H), 3.59-3.46 (multiple peaks, 2H), 2.86 (multiple peaks, 1H).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556
[2] Patent: US7045545, 2006, B1. Location in patent: Page/Page column 26
[3] Letters in Organic Chemistry, 2010, vol. 7, # 5, p. 353 - 359
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4601 - 4608
[5] Patent: WO2014/159224, 2014, A1. Location in patent: Paragraph 00280

N-Boc-D-alaninol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-D-alaninol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Boc-D-alaninol 106391-86-0
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-10-19
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-Ala-Ol 106391-86-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-14
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Boc-D-Ala-Ol 106391-86-0
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-02

106391-86-0, N-Boc-D-alaninolRelated Search:

1-Propanol tert-Butyl acetate Cyromazine tert-Butyl peroxyacetate tert-Butanol (R)-(-)-2-Amino-1-propanol EC 2.6.1.2 (S)-(-)-2-Methyl-1-butanol N-Carbobenzyloxyglycine N-Boc-N'-Cbz-L-lysine BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-L-Prolinal N-Boc-D-Phenylalaninol N-Boc-L-lysine methyl ester hydrochloride 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate BOC-N-ME-DL-PHG-OH BOC-D-ABU-OH Carbonyl iron powder

  • (R)-tert-butyl 1-hydroxypropan-2-ylcarbamate
  • REF DUPL: Boc-D-Alaninol
  • (R)-2-(Boc-amino)-1-propanol,(R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol, N-Boc-D-alaninol
  • Bayer Schering
  • (2R)-2-Aminopropan-1-ol, N-BOC protected
  • tert-Butyl [(2R)-1-hydroxyprop-2-yl]carbamate, D-Alaninol, N-BOC protected
  • (R)-2-(Boc-amino)-1-propanol 98%, optical purity ee: 98% (GLC)
  • N-Boc-D-alaninol,99%e.e.
  • Boc-D-Alaninol≥ 98% (GC)
  • N-boc-d-alanine alcohol
  • BOC-(R)-2-AMINO-1-PROPANOL
  • BOC-D-ALA-OL
  • BOC-D-ALANINOL
  • 2R-BOC-AMINO-1-PROPANOL
  • N-T-BOC-D-ALANINOL
  • N-T-BUTOXYCARBONYL-D-ALANINOL
  • (R)-(+)-2-(BOC-AMINO)-1-PROPANOL
  • (R)-2-(BOC-AMINO)-1-PROPANOL
  • (R)-2-(TERT-BUTYLOXYCARBONYL-AMINO)-1-PROPANOL
  • (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-1-PROPANOL
  • N-ALPHA-T-BOC-D-ALANINOL
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-D-ALANINOL
  • N-BOC-D-ALANINOL
  • d-BOC-Alaninol
  • (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-1-P ROPANOL, 98% (98% EE/GLC)
  • Carbamic acid, [(1R)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
  • N-TERT-BOC-D-ALANINOL
  • N-tert-Butoxycarbonyl-D-alaninol
  • tert-butyl (R)-1-hydroxypropan-2-ylcarbamate
  • N-Boc-D-alaninol, 98%, ee 98%
  • (R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol, N-Boc-D-alaninol
  • tert-butyl N-[(1R)-2-hydroxy-1-methyl-ethyl]carbamate
  • tert-butyl N-[(2R)-1-hydroxypropan-2-yl]carbamate
  • N-Boc-D-alanino
  • -(+)-2-(BOC-amino)-1-propanol
  • Carbamic acid, N-[(1R)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester
  • N-Boc-D-alaninol USP/EP/BP
  • N-Boc-D-propanol
  • oc-D-Alaninol
  • 1,1-Dimethylethyl?N-[(1R)-2-hydroxy-1-methylethyl]carbamate
  • CAS:106391-86-0
  • (<i>R</i>)-2-(Boc-amino)-1-propanol
  • BOC-D-alaninol - [A7973]
  • 106391-86-0
  • 32449-92-0
  • Amino Acid Derivatives
  • Amino Alcohols
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Alcohols
  • Boc-Amino acid series
  • Amino Acids
  • N-BOC