N-BOC-O-Benzyl-L-serine

Product Name: N-BOC-O-Benzyl-L-serine
CAS No.: 23680-31-1
Chemical Name: N-BOC-O-Benzyl-L-serine
Synonyms: BOC-SER-OTBU;BOC-1-SER-OH;BOC-SER(BU)-OH;Boc-Ser(Bz1)-OH;BOC-SER(TBU)-OH;BOC-SER(BUT)-OH;Boc-Ser(Bzl)-0H;BOC-Ser (Obzl) OH;BOC-L-SER(TBU)-OH;Boc-L-Ser(OBzl)-OH
CBNumber: CB9172315
Molecular Formula: C15H21NO5
Formula Weight: 295.33
MOL File: 23680-31-1.mol

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N-BOC-O-Benzyl-L-serine Property

Melting point:: 58-60 °C(lit.)
alpha: 21.5 º (c=2, ethanol)
Boiling point:: 437.02°C (rough estimate)
Density: 1.1454 (rough estimate)
refractive index: 22 ° (C=2, EtOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Solid
pka: 3.53±0.10(Predicted)
color: White to Almost white
optical activity: [α]20/D +20±1°, c = 2% in ethanol: water (4:1)
BRN: 3064461
InChIKey: DMBKPDOAQVGTST-LBPRGKRZSA-N
CAS DataBase Reference: 23680-31-1(CAS DataBase Reference)
EPA Substance Registry System: N-tert-Butoxycarbonyl-O-benzyl-L-serine (23680-31-1)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53009
Product name: Boc-Ser(Bzl)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53009
Product name: Boc-Ser(Bzl)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $238
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53009
Product name: Boc-Ser(Bzl)-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2140
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53009
Product name: Boc-Ser(Bzl)-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2140
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15390
Product name: Boc-Ser(Bzl)-OH
Purity: ≥99.0% (T)
Packaging: 5g
Price: $47.5
Updated: 2025/07/31

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N-BOC-O-Benzyl-L-serine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-O-benzyl-L-serine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

3262-72-4

100-39-0

23680-31-1

Example 36 Synthesis of N-tert-butoxycarbonyl-O-benzyl-L-serine 39: Boc-L-serine (15 g, 73.09 mmol) was dissolved in DMF (300 mL) at 0 °C, NaH (6.43 g, 160.80 mmol, 60% mineral oil dispersion) was slowly added, and the reaction temperature was maintained at 0 °C and stirred for 1.5 hours. Subsequently, benzyl bromide (13.75 g, 80.40 mmol) was added, and the reaction mixture was gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, DMF was removed by evaporation under reduced pressure and the residue was dissolved in H2O. The crude product was partitioned between water and Et2O. The aqueous phase was acidified with 3N HCl to pH < 4 and then extracted three times with EtOAc. The EtOAc extracts were combined, washed with H2O, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give N-tert-butoxycarbonyl-O-benzyl-L-serine (17.27 g, 80% yield).

References

[1] Tetrahedron Letters, 2012, vol. 53, # 26, p. 3225 - 3229
[2] Patent: US2004/121316, 2004, A1
[3] Patent: US2005/239054, 2005, A1
[4] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 00145
[5] Patent: WO2018/26763, 2018, A1. Location in patent: Page/Page column 81

N-BOC-O-Benzyl-L-serine Preparation Products And Raw materials

Raw materials

BOC-L-Serine Sodium hydride N,N-Dimethylformamide 1,4-Dioxane Benzyl bromide Diethyl ether Ethyl acetate Hydrochloric acid O-BENZYL-L-SERINE

Preparation Products

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N-BOC-O-Benzyl-L-serine Suppliers

Americas 1 Belgium 1 China 232 Europe 3 Germany 6 Hungary 1 India 14 Ireland 1 Japan 4 Poland 1 South Korea 1 Switzerland 4 United Kingdom 13 United States 47 Global 329

Sichuan jiayinglai technology CO.,LTD

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Nantong puyue biomedical Co., Ltd

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Energy Chemical

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View Lastest Price from N-BOC-O-Benzyl-L-serine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-Ser(Bzl)-OH 23680-31-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-23

airuikechemical co., ltd.

Product: n-bOc-O-benzyl-l-serine 23680-31-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serine 23680-31-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

23680-31-1, N-BOC-O-Benzyl-L-serineRelated Search:

BOC-D-Alanine D-Cycloserine tert-Butanol Benzyl bromide DL-Serine Benzyl chloride tert-Butyl carbazate PYRAZOPHOS Benzyl alcohol L-Homoserine L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE Boc-Ser(tBu)-OH L-Serine N-Carbobenzyloxyglycine CARBONYL SULFIDE Benzyl benzoate Boc-D-Ser(Bzl)-OH Boc-His(Trt)-OH

N-BOC-O-Benzyl-L-ser

N-Boc-O-benzyl-L-serine Boc-Ser(Bzl)-OH

Boc-Ser(Bz1)-OH

(S)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid

N-BOC-O-BENZYL-SERINE

(2S)-3-Benzyloxy-2-(tert-butoxycarbonylamino)propanoic acid

L-SERINE-N-T-BOC, O-BZ ETHER (15N)

L-SERINE-N-T-BOC, O-BZ ETHER (2-13C)

L-SERINE-N-T-BOC, O-BZ ETHER (3-13C)

Boc-Ser(Bzl)-OH >=99.0% (T)

Boc-O-benzyl-L-serine≥ 99% (HPLC)

BOC-Ser (Obzl) OH

(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)propanoic acid

N-(tert-Butoxycarbonyl)-O-benzylserine

N-(tert-Butyloxycarbonyl)-O-benzyl-L-serine

N-[(tert-Butyloxy)carbonyl]-O-benzyl-L-serine

O-Benzyl-N-(tert-butoxycarbonyl)-L-serine

N-BOC-O-Benzyl-L-serine,98%

(Tert-Butoxy)Carbonyl Ser(Bzl)-OH

Boc-O-benzyl-L-serine, N-(tert-Butoxycarbonyl)-O-benzyl-L-serine

Boc-L-Ser(OBzl)-OH

(S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)prop/N-BOC-O-Benzyl-L-serine

N-(tert-Butoxycarbonyl)-O-benzyl-L-serine ,99%

BOC-SER(TBU)-OH

BOC-SERINE(TBU)-OH

BOC-SER-OTBU

BOC-SER(BUT)-OH

BOC-SER(BU)-OH

BOC-L-SER(TBU)-OH

BOC-O-T-BUTYL-L-SERINE

n-[(1,1-dimethylethoxy)carbonyl]-o-(phenylmethyl)-l-serin

N-ALPHA-TERT-BUTYLOXYCARBONYL-O-TERT-BUTYL-L-SERINE

N-ALPHA-T-BUTOXYCARBONYL-O-T-BUTYL-L-SERINE

N-T-BOC-O-BENZYL-L-SERINE CRYSTALLINE

N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE

NALPHA-tert-Butoxycarbonyl-O-benzyl-L-serine

N-(tert-Butoxycarbonyl)-O-benzyl-L-serine

N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serine

N-BOC-O-Benzyl-L-serine

BOC-O-BENZYL-L-SER-OH

(2S)-3-Benzyloxy-2-(tert-butoxycarbonylamino)propanoic acid 98%

N-(tert-Butoxycarbonyl)-O-benzyl-L-serine &gt

BOC-1-SER-OH

N-α-t-BOC-o-benzyl-L-serine

Boc-O-benzyl-L-serine, 98%+

TIANFU CHEM---N-BOC-O-Benzyl-L-serine

N-BOC-O-Benzyl-L-Serine extrapure, 98%

N-Boc-O-benzyl-L-serine, 97%

Boc-Ser(Bzl)-0H

23680-31-1

C6H5CH2OCH2CHCOOHNHCOOCCH33

C15H21NO5

Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Serine

Boc-Amino Acids

Boc-Amino acid series