O-BENZYL-L-SERINE
- Product Name
- O-BENZYL-L-SERINE
- CAS No.
- 4726-96-9
- Chemical Name
- O-BENZYL-L-SERINE
- Synonyms
- H-ser(Obzl)-OH;H-SER(BZL)-OH;BENZYL-L-SERINE;H-L-SER(BZL)-OH;L-Serine, O-(phenylmethyl)-;L-Ser(Bzl)-OH;SERINE(BZL)-OH;L-O-Benzylserine;O-BENZYL-L-SERINE;O-benzyl-L-aerine
- CBNumber
- CB8439589
- Molecular Formula
- C10H13NO3
- Formula Weight
- 195.22
- MOL File
- 4726-96-9.mol
O-BENZYL-L-SERINE Property
- Melting point:
- ~227 °C (dec.)
- Boiling point:
- 359℃
- Density
- 1.217
- refractive index
- 7.3 ° (C=2, 1mol/L HCl)
- Flash point:
- 171℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Powder
- pka
- 2.10±0.10(Predicted)
- color
- White to off-white
- optical activity
- [α]20/D +21±2°, c = 2% in acetic acid: water (4:1) (+ 1 Eq HCl)
- BRN
- 2114846
- CAS DataBase Reference
- 4726-96-9(CAS DataBase Reference)
- EPA Substance Registry System
- L-Serine, O-(phenylmethyl)- (4726-96-9)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 13900
- Product name
- O-Benzyl-L-serine
- Purity
- ≥99.0% (NT)
- Packaging
- 5G
- Price
- $103
- Updated
- 2022/05/15
- Product number
- B0861
- Product name
- O-Benzyl-L-serine
- Purity
- >99.0%(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B0861
- Product name
- O-Benzyl-L-serine
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- B316180
- Product name
- O-Benzyl-L-Serine
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 241019
- Product name
- O-Benzyl-L-serine 99+%
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
O-BENZYL-L-SERINE Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
O-Benzyl-L-Serine is used in the preparation of serine analogs as specific agonists for NMDA receptor glycine binding sites. It also functions as an eluent for ligand exchange chromatography for the separation of constrained glutamate receptor ligands.
Definition
ChEBI: O-BENZYL-l-SERINE is a L-alpha-amino acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
23680-31-1
4726-96-9
The general procedure for the synthesis of (S)-2-amino-3-(benzyloxy)propionic acid from N-BOC-O-benzyl-L-serine was as follows: the compound obtained in the previous step was dissolved in an appropriate amount of dry dichloromethane (DCM), 1.0 mL of trifluoroacetic acid (TFA) and 0.1 mL of triethylsilane were added, and the reaction was stirred for 2 hr at room temperature, and the reaction was monitored by thin-layer chromatography (TLC) The reaction was monitored until complete. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7?8 with saturated sodium bicarbonate solution and subsequently diluted with the addition of dichloromethane (DCM). The organic phase was washed twice with saturated brine and then concentrated to give a yellow oily liquid. Finally, the product was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=15:1) to give a yellow powdery solid product in 62.3% yield.
References
[1] Patent: CN107082754, 2017, A. Location in patent: Paragraph 0119; 0124
[2] Organic Process Research and Development, 2003, vol. 7, # 4, p. 521 - 532
[3] Tetrahedron Letters, 2014, vol. 55, # 30, p. 4149 - 4151
[4] ACS Chemical Neuroscience, 2017, vol. 8, # 8, p. 1681 - 1687
[5] Patent: WO2017/189866, 2017, A1. Location in patent: Paragraph 0210
O-BENZYL-L-SERINE Preparation Products And Raw materials
Raw materials
Preparation Products
O-BENZYL-L-SERINE Suppliers
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View Lastest Price from O-BENZYL-L-SERINE manufacturers
- Product
- O-Benzyl-L-serine 4726-96-9
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-09
- Product
- O-BENZYL-L-SERINE 4726-96-9
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-08-25
- Product
- O-BENZYL-L-SERINE 4726-96-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22