ChemicalBook > CAS DataBase List > N-BOC-O-Benzyl-L-serine

N-BOC-O-Benzyl-L-serine

Product Name
N-BOC-O-Benzyl-L-serine
CAS No.
23680-31-1
Chemical Name
N-BOC-O-Benzyl-L-serine
Synonyms
BOC-SER-OTBU;BOC-1-SER-OH;BOC-SER(BU)-OH;Boc-Ser(Bz1)-OH;BOC-SER(TBU)-OH;BOC-SER(BUT)-OH;Boc-Ser(Bzl)-0H;BOC-Ser (Obzl) OH;BOC-L-SER(TBU)-OH;Boc-L-Ser(OBzl)-OH
CBNumber
CB9172315
Molecular Formula
C15H21NO5
Formula Weight
295.33
MOL File
23680-31-1.mol
More
Less

N-BOC-O-Benzyl-L-serine Property

Melting point:
58-60 °C(lit.)
alpha 
21.5 º (c=2, ethanol)
Boiling point:
437.02°C (rough estimate)
Density 
1.1454 (rough estimate)
refractive index 
22 ° (C=2, EtOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Solid
pka
3.53±0.10(Predicted)
color 
White to Almost white
optical activity
[α]20/D +20±1°, c = 2% in ethanol: water (4:1)
BRN 
3064461
InChIKey
DMBKPDOAQVGTST-LBPRGKRZSA-N
CAS DataBase Reference
23680-31-1(CAS DataBase Reference)
EPA Substance Registry System
N-tert-Butoxycarbonyl-O-benzyl-L-serine (23680-31-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
TSCA 
Yes
HS Code 
2924 29 70
HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53009
Product name
Boc-Ser(Bzl)-OH
Purity
Novabiochem?
Packaging
25g
Price
$161
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53009
Product name
Boc-Ser(Bzl)-OH
Purity
Novabiochem?
Packaging
100g
Price
$238
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53009
Product name
Boc-Ser(Bzl)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$2140
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53009
Product name
Boc-Ser(Bzl)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$2140
Updated
2025/07/31
Sigma-Aldrich
Product number
15390
Product name
Boc-Ser(Bzl)-OH
Purity
≥99.0% (T)
Packaging
5g
Price
$47.5
Updated
2025/07/31
More
Less

N-BOC-O-Benzyl-L-serine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-O-benzyl-L-serine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

3262-72-4

100-39-0

23680-31-1

Example 36 Synthesis of N-tert-butoxycarbonyl-O-benzyl-L-serine 39: Boc-L-serine (15 g, 73.09 mmol) was dissolved in DMF (300 mL) at 0 °C, NaH (6.43 g, 160.80 mmol, 60% mineral oil dispersion) was slowly added, and the reaction temperature was maintained at 0 °C and stirred for 1.5 hours. Subsequently, benzyl bromide (13.75 g, 80.40 mmol) was added, and the reaction mixture was gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, DMF was removed by evaporation under reduced pressure and the residue was dissolved in H2O. The crude product was partitioned between water and Et2O. The aqueous phase was acidified with 3N HCl to pH < 4 and then extracted three times with EtOAc. The EtOAc extracts were combined, washed with H2O, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give N-tert-butoxycarbonyl-O-benzyl-L-serine (17.27 g, 80% yield).

References

[1] Tetrahedron Letters, 2012, vol. 53, # 26, p. 3225 - 3229
[2] Patent: US2004/121316, 2004, A1
[3] Patent: US2005/239054, 2005, A1
[4] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 00145
[5] Patent: WO2018/26763, 2018, A1. Location in patent: Page/Page column 81

N-BOC-O-Benzyl-L-serine Preparation Products And Raw materials

Raw materials

BOC-L-Serine Sodium hydride N,N-Dimethylformamide 1,4-Dioxane Benzyl bromide Diethyl ether Ethyl acetate Hydrochloric acid O-BENZYL-L-SERINE

Preparation Products

More
Less

N-BOC-O-Benzyl-L-serine Suppliers

Americas 1 Belgium 1 China 232 Europe 3 Germany 6 Hungary 1 India 14 Ireland 1 Japan 4 Poland 1 South Korea 1 Switzerland 4 United Kingdom 13 United States 47 Global 329
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
Nantong puyue biomedical Co., Ltd
Tel
0513-0513-0513-89158300 18014392889
Fax
0513-89158198
Email
sales@puyerbiopharma.com
Country
China
ProdList
4956
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
28-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
510
Advantage
57
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
21-33585366 13311639313
Fax
+86-21-34979012
Email
sales@shyrchem.com
Country
China
ProdList
806
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Tianjin Chempharmatech Co.,Ltd.
Tel
022-66211079 13212288319
Fax
qq1405432731
Email
sales@chempharmatech.com
Country
China
ProdList
915
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Sinfachem Limited
Tel
025-84683399 13952017251
Fax
025-84683112
Email
sales@sinfachem.com
Country
China
ProdList
217
Advantage
56
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Nanjing Credit Trading Co.,Ltd
Tel
025-52164950
Fax
025-86800069
Email
Googlexu_0114@sina.com
Country
China
ProdList
644
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
023-13650506873 19923294409
Email
xingcanyaoye@sina.com
Country
China
ProdList
1604
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773/021-31606483/2934163037
Fax
021-61317773-604
Email
sales@aspirebio.com
Country
China
ProdList
257
Advantage
58
Sichuan Ampebiochem Co., Ltd.
Tel
028-65294243 13981822079;18682730901
Email
sales@ampebiochem.com
Country
China
ProdList
1000
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Nanjing Derno Pharmaceutical Technology Co., Ltd.
Tel
025-86957866 13952093866
Fax
025-68661287
Email
sales@dernopharm.com
Country
China
ProdList
932
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
ProdList
904
Advantage
55
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
More
Less

View Lastest Price from N-BOC-O-Benzyl-L-serine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-Ser(Bzl)-OH 23680-31-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-23
airuikechemical co., ltd.
Product
n-bOc-O-benzyl-l-serine 23680-31-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serine 23680-31-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

23680-31-1, N-BOC-O-Benzyl-L-serineRelated Search:

BOC-D-Alanine D-Cycloserine tert-Butanol Benzyl bromide DL-Serine Benzyl chloride tert-Butyl carbazate PYRAZOPHOS Benzyl alcohol L-Homoserine L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE Boc-Ser(tBu)-OH L-Serine N-Carbobenzyloxyglycine CARBONYL SULFIDE Benzyl benzoate Boc-D-Ser(Bzl)-OH Boc-His(Trt)-OH

  • N-BOC-O-Benzyl-L-ser
  • N-Boc-O-benzyl-L-serine Boc-Ser(Bzl)-OH
  • Boc-Ser(Bz1)-OH
  • (S)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid
  • N-BOC-O-BENZYL-SERINE
  • (2S)-3-Benzyloxy-2-(tert-butoxycarbonylamino)propanoic acid
  • L-SERINE-N-T-BOC, O-BZ ETHER (15N)
  • L-SERINE-N-T-BOC, O-BZ ETHER (2-13C)
  • L-SERINE-N-T-BOC, O-BZ ETHER (3-13C)
  • Boc-Ser(Bzl)-OH >=99.0% (T)
  • Boc-O-benzyl-L-serine≥ 99% (HPLC)
  • BOC-Ser (Obzl) OH
  • (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)propanoic acid
  • N-(tert-Butoxycarbonyl)-O-benzylserine
  • N-(tert-Butyloxycarbonyl)-O-benzyl-L-serine
  • N-[(tert-Butyloxy)carbonyl]-O-benzyl-L-serine
  • O-Benzyl-N-(tert-butoxycarbonyl)-L-serine
  • N-BOC-O-Benzyl-L-serine,98%
  • (Tert-Butoxy)Carbonyl Ser(Bzl)-OH
  • Boc-O-benzyl-L-serine, N-(tert-Butoxycarbonyl)-O-benzyl-L-serine
  • Boc-L-Ser(OBzl)-OH
  • (S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)prop/N-BOC-O-Benzyl-L-serine
  • N-(tert-Butoxycarbonyl)-O-benzyl-L-serine ,99%
  • BOC-SER(TBU)-OH
  • BOC-SERINE(TBU)-OH
  • BOC-SER-OTBU
  • BOC-SER(BUT)-OH
  • BOC-SER(BU)-OH
  • BOC-L-SER(TBU)-OH
  • BOC-O-T-BUTYL-L-SERINE
  • n-[(1,1-dimethylethoxy)carbonyl]-o-(phenylmethyl)-l-serin
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-TERT-BUTYL-L-SERINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-T-BUTYL-L-SERINE
  • N-T-BOC-O-BENZYL-L-SERINE CRYSTALLINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE
  • NALPHA-tert-Butoxycarbonyl-O-benzyl-L-serine
  • N-(tert-Butoxycarbonyl)-O-benzyl-L-serine
  • N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serine
  • N-BOC-O-Benzyl-L-serine
  • BOC-O-BENZYL-L-SER-OH
  • (2S)-3-Benzyloxy-2-(tert-butoxycarbonylamino)propanoic acid 98%
  • N-(tert-Butoxycarbonyl)-O-benzyl-L-serine &gt
  • BOC-1-SER-OH
  • N-α-t-BOC-o-benzyl-L-serine
  • Boc-O-benzyl-L-serine, 98%+
  • TIANFU CHEM---N-BOC-O-Benzyl-L-serine
  • N-BOC-O-Benzyl-L-Serine extrapure, 98%
  • N-Boc-O-benzyl-L-serine, 97%
  • Boc-Ser(Bzl)-0H
  • 23680-31-1
  • C6H5CH2OCH2CHCOOHNHCOOCCH33
  • C15H21NO5
  • Amino Acid Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • Serine
  • Boc-Amino Acids
  • Boc-Amino acid series