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Boc-D-Ser(Bzl)-OH

Product Name
Boc-D-Ser(Bzl)-OH
CAS No.
47173-80-8
Chemical Name
Boc-D-Ser(Bzl)-OH
Synonyms
O-BENZYL-N-(TERT-BUTOXYCARBONYL)-D-SERINE;BOC-SER(BZL)-OH;BOC-SER(BZL);BOC-D-SER(BZL);BOC-O-BENZYL-L-SERINE;(R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid;(2R)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid;BOC-L-SER(BZL);(2R)-3-(benzylox;BOC-D-SER(BZL)-OH
CBNumber
CB5438415
Molecular Formula
C15H21NO5
Formula Weight
295.33
MOL File
47173-80-8.mol
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Boc-D-Ser(Bzl)-OH Property

Melting point:
58-60 °C(lit.)
alpha 
-19 º (c=2 80% alcohol)
Boiling point:
437.02°C (rough estimate)
Density 
1.1454 (rough estimate)
refractive index 
-20 ° (C=2, 80% EtOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Methanol
pka
3.53±0.10(Predicted)
form 
Powder
color 
White
BRN 
2665080
Major Application
peptide synthesis
InChI
InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1
InChIKey
DMBKPDOAQVGTST-GFCCVEGCSA-N
SMILES
C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
47173-80-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53111
Product name
Boc-D-Ser(Bzl)-OH
Purity
Novabiochem?
Packaging
25g
Price
$851
Updated
2025/07/31
Sigma-Aldrich
Product number
15078
Product name
Boc-D-Ser(Bzl)-OH
Purity
≥98.0% (HPLC)
Packaging
5g
Price
$389
Updated
2025/07/31
TCI Chemical
Product number
B1863
Product name
O-Benzyl-N-(tert-butoxycarbonyl)-D-serine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$66
Updated
2025/07/31
TCI Chemical
Product number
B1863
Product name
O-Benzyl-N-(tert-butoxycarbonyl)-D-serine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$212
Updated
2025/07/31
Usbiological
Product number
261925
Product name
Boc-O-benzyl-L-serine
Packaging
5g
Price
$289
Updated
2021/12/16
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Boc-D-Ser(Bzl)-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Biological Activity

Boc-O-benzyl-D-serine is an inhibitor of the uptake of galactose and its derivatives. It has potent inhibitory activity against the uptake of galactose, glucose, and lactose. This drug is also effective in inhibiting the uptake of tetrazole, a substance that inhibits glycolysis. Boc-O-benzyl-D-serine is able to inhibit atherosclerotic lesions caused by piperidine, which has been shown to be synthesized from benzyl alcohol and piperidine. The oral administration of this compound can enhance fibroblast cells that are resistant to insulin.

Synthesis

N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification.

Boc-D-Ser(Bzl)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-D-Ser(Bzl)-OH Suppliers

Americas 1 Belgium 1 China 214 Europe 2 France 1 Germany 5 Hungary 1 India 9 Ireland 1 Japan 10 Switzerland 5 United Kingdom 7 United States 44 Global 301
Jinan XuanDe Chemical Co., Ltd.
Tel
0531-0531-88803958 19862127196
Fax
0531-82777287
Email
zhangxu@shiningpharm.com
Country
China
ProdList
194
Advantage
58
Sichuan HongRi Pharma-Tech Co., Ltd
Tel
1898-2685405 18380436509
Fax
0838-2822568
Email
2065506070@qq.com
Country
China
ProdList
2025
Advantage
58
Shandong Yuhe Pharmaceutical Technology Co., LTD
Tel
15263077727
Fax
QQ：2938966534
Email
1436425847@qq.com
Country
China
ProdList
283
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58
Chengdu ruihede Medical Technology Co., Ltd
Tel
17381862311; 17381862311
Email
sales2@ruihede.cn
Country
China
ProdList
277
Advantage
58
Suzhou Myland Nutraceuticals Inc.
Tel
66702819 13382131678
Fax
0086-512-66700657
Email
jc@mylandpharm.com
Country
China
ProdList
59
Advantage
55
Shandong Mingfeng Pharmaceutical and Technology Co. Ltd
Tel
053155551677 15315114555
Fax
QQ:1345456643
Email
1345456643@qq.com
Country
China
ProdList
264
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from Boc-D-Ser(Bzl)-OH manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
N-Boc-O-Benzyl-D-serine 47173-80-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-29
Shaanxi Xianhe Biotech Co., Ltd
Product
N-Boc-O-Benzyl-D-serine 47173-80-8
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
1000KG
Release date
2025-05-06
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-D-Ser(Bzl)-OH 47173-80-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-23

47173-80-8, Boc-D-Ser(Bzl)-OHRelated Search:

Benzyl chloride D-Serine Benzyl benzoate L-Homoserine tert-Butanol Boc-Ser(tBu)-OH N-Carbobenzyloxyglycine Benzyl bromide DL-Serine Benzyltriethylammonium chloride Benzyl alcohol L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE Boc-Aib-OH D-Cycloserine Benzyltrimethylammonium chloride Boc-O-benzyl-L-serine, N-(tert-Butoxycarbonyl)-O-benzyl-L-serine,N-BOC-O-Benzyl-L-serine,N-T-BOC-O-BENZYL-L-SERINE CRYSTALLINE BOC-GLY-LEU-OH Boc-His(Trt)-OH

  • (2R)-2-(tert-butoxycarbonylamino)-3-(phenylmethoxy)propanoic acid
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)propanoic acid
  • (2R)-2-[(tert-butoxy-oxomethyl)amino]-3-(phenylmethoxy)propanoic acid
  • (2R)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propionic acid
  • L-Serine, N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-
  • Boc-D-Ser(Bzl)-OH, >=98%
  • BOC-D-SERINE(BZL)-OH
  • BOC-D-SER(BZL)-OH
  • BOC-SER(BZL)-OH
  • BOC-SER(BZL)
  • BOC-SERINE(BZL)-OH
  • BOC-(S)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
  • BOC-O-BENZYL-D-SERINE
  • BOC-O-BENZYL-L-SERINE
  • BOC-(R)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
  • BOC-L-SER(BZL)-OH
  • BOC-L-SERINE (BZL)
  • BOC-L-SER(BZL)
  • <i>O</i>-Benzyl-<i>N</i>-(<i>tert</i>-butoxycarbonyl)-<small>D</small>-serine
  • Boc-O-benzyl-D-serine≥ 99.5% (HPLC)
  • NALPHA-tert-Butoxycarbonyl-O-benzyl-D-serine
  • N-BOC-O-Benzyl-D-serine,98%
  • N-t-BOC-O-Benzyl-D-serine
  • N-Boc-O-Benzyl-D-ser
  • Boc-D-Ser(Bzl)-OH Boc-O-benzyl-D-Serine
  • N-Boc-O-benzyl-D-serine Boc-D-Ser(Bzl)-OH
  • (R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid
  • T-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • T-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE
  • TBOC-L-SERINE (BZL)
  • N-ALPHA-T-BOC-O-BENZYL-L-SERINE
  • N-ALPHA-T-BOC-O-BENZYL-D-SERINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-SERINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • N-ALPHA-TERT-BOC-O-BENZYL-L-SERINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE
  • N-BOC-O-BENZYL-D-SERINE
  • Boc-DL-Ser(Bzl)-OH
  • O-BENZYL-N-(TERT-BUTOXYCARBONYL)-D-SERINE
  • N-TERT-BUTOXYCARBONYL-O-BENZYL-D-SERINE
  • N-T-BUTOXYCARBONYL-O-BENZYL-L-SERINE
  • (Tert-Butoxy)Carbonyl D-Ser(Bzl)-OH
  • (2R)-3-(benzylox
  • BOC-D-SER(BZL)
  • (2R)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
  • O-Benzyl-N-Boc-D-serine
  • O-Benzyl-N-(tert-butoxycarbonyl)-D-serine &gt
  • D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-
  • N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-D-serine
  • (s)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol
  • BOC-D-Ser(OBZL)-OH
  • Boc-<sc>D</sc>-Ser(Bzl)-OH
  • (R)-3-(benzyloxy)-2-((tertbutyloxyoxo)amino)propanoic acid
  • 47173-80-8
  • 47473-80-8
  • 47173-80-6
  • C15H20NO5