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Boc-D-Ser(Bzl)-OH

Product Name
Boc-D-Ser(Bzl)-OH
CAS No.
47173-80-8
Chemical Name
Boc-D-Ser(Bzl)-OH
Synonyms
O-BENZYL-N-(TERT-BUTOXYCARBONYL)-D-SERINE;BOC-SER(BZL)-OH;BOC-SER(BZL);BOC-D-SER(BZL);BOC-O-BENZYL-L-SERINE;(R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid;(2R)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid;BOC-L-SER(BZL);(2R)-3-(benzylox;BOC-D-SER(BZL)-OH
CBNumber
CB5438415
Molecular Formula
C15H21NO5
Formula Weight
295.33
MOL File
47173-80-8.mol
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Boc-D-Ser(Bzl)-OH Property

Melting point:
58-60 °C(lit.)
alpha 
-19 º (c=2 80% alcohol)
Boiling point:
437.02°C (rough estimate)
Density 
1.1454 (rough estimate)
refractive index 
-20 ° (C=2, 80% EtOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Methanol
pka
3.53±0.10(Predicted)
form 
Powder
color 
White
BRN 
2665080
InChI
InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1
InChIKey
DMBKPDOAQVGTST-GFCCVEGCSA-N
SMILES
C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
47173-80-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53111
Product name
Boc-D-Ser(Bzl)-OH
Purity
Novabiochem?
Packaging
25g
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
15078
Product name
Boc-D-Ser(Bzl)-OH
Purity
≥98.0% (HPLC)
Packaging
5g
Price
$413
Updated
2024/03/01
TCI Chemical
Product number
B1863
Product name
O-Benzyl-N-(tert-butoxycarbonyl)-D-serine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
B1863
Product name
O-Benzyl-N-(tert-butoxycarbonyl)-D-serine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$212
Updated
2024/03/01
Alfa Aesar
Product number
B22666
Product name
N-Boc-O-benzyl-D-serine, 99%
Packaging
5g
Price
$180
Updated
2021/12/16
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Boc-D-Ser(Bzl)-OH Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases.

Biological Activity

Boc-O-benzyl-D-serine is an inhibitor of the uptake of galactose and its derivatives. It has potent inhibitory activity against the uptake of galactose, glucose, and lactose. This drug is also effective in inhibiting the uptake of tetrazole, a substance that inhibits glycolysis. Boc-O-benzyl-D-serine is able to inhibit atherosclerotic lesions caused by piperidine, which has been shown to be synthesized from benzyl alcohol and piperidine. The oral administration of this compound can enhance fibroblast cells that are resistant to insulin.

Synthesis

N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification.

Boc-D-Ser(Bzl)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-D-Ser(Bzl)-OH Suppliers

Americas 1 Belgium 1 China 176 Europe 2 France 1 Germany 5 Hungary 1 India 9 Ireland 1 Japan 10 Switzerland 5 United Kingdom 7 United States 43 Global 262
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Boc-D-Ser(Bzl)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-Ser(Bzl)-OH 47173-80-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-D-Ser(Bzl)-OH 47173-80-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-23
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-D-Ser(Bzl)-OH 47173-80-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-21

47173-80-8, Boc-D-Ser(Bzl)-OHRelated Search:

Benzyl chloride D-Serine Benzyl benzoate L-Homoserine tert-Butanol Boc-Ser(tBu)-OH N-Carbobenzyloxyglycine Benzyl bromide DL-Serine Benzyltriethylammonium chloride Benzyl alcohol L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE Boc-Aib-OH D-Cycloserine Benzyltrimethylammonium chloride Boc-O-benzyl-L-serine, N-(tert-Butoxycarbonyl)-O-benzyl-L-serine,N-BOC-O-Benzyl-L-serine,N-T-BOC-O-BENZYL-L-SERINE CRYSTALLINE BOC-GLY-LEU-OH Boc-His(Trt)-OH

  • (2R)-2-(tert-butoxycarbonylamino)-3-(phenylmethoxy)propanoic acid
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)propanoic acid
  • (2R)-2-[(tert-butoxy-oxomethyl)amino]-3-(phenylmethoxy)propanoic acid
  • (2R)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)propionic acid
  • L-Serine, N-((1,1-dimethylethoxy)carbonyl)-O-(phenylmethyl)-
  • Boc-D-Ser(Bzl)-OH, >=98%
  • BOC-D-SERINE(BZL)-OH
  • BOC-D-SER(BZL)-OH
  • BOC-SER(BZL)-OH
  • BOC-SER(BZL)
  • BOC-SERINE(BZL)-OH
  • BOC-(S)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
  • BOC-O-BENZYL-D-SERINE
  • BOC-O-BENZYL-L-SERINE
  • BOC-(R)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
  • BOC-L-SER(BZL)-OH
  • BOC-L-SERINE (BZL)
  • BOC-L-SER(BZL)
  • <i>O</i>-Benzyl-<i>N</i>-(<i>tert</i>-butoxycarbonyl)-<small>D</small>-serine
  • Boc-O-benzyl-D-serine≥ 99.5% (HPLC)
  • NALPHA-tert-Butoxycarbonyl-O-benzyl-D-serine
  • N-BOC-O-Benzyl-D-serine,98%
  • N-t-BOC-O-Benzyl-D-serine
  • N-Boc-O-Benzyl-D-ser
  • Boc-D-Ser(Bzl)-OH Boc-O-benzyl-D-Serine
  • N-Boc-O-benzyl-D-serine Boc-D-Ser(Bzl)-OH
  • (R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoic acid
  • T-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • T-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE
  • TBOC-L-SERINE (BZL)
  • N-ALPHA-T-BOC-O-BENZYL-L-SERINE
  • N-ALPHA-T-BOC-O-BENZYL-D-SERINE
  • N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-SERINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • N-ALPHA-TERT-BOC-O-BENZYL-L-SERINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-L-SERINE
  • N-BOC-O-BENZYL-D-SERINE
  • Boc-DL-Ser(Bzl)-OH
  • O-BENZYL-N-(TERT-BUTOXYCARBONYL)-D-SERINE
  • N-TERT-BUTOXYCARBONYL-O-BENZYL-D-SERINE
  • N-T-BUTOXYCARBONYL-O-BENZYL-L-SERINE
  • (Tert-Butoxy)Carbonyl D-Ser(Bzl)-OH
  • (2R)-3-(benzylox
  • BOC-D-SER(BZL)
  • (2R)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid
  • O-Benzyl-N-Boc-D-serine
  • O-Benzyl-N-(tert-butoxycarbonyl)-D-serine &gt
  • D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-
  • N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-D-serine
  • (s)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol
  • BOC-D-Ser(OBZL)-OH
  • 47173-80-8
  • 47473-80-8
  • 47173-80-6
  • C15H20NO5
  • Specialty Synthesis
  • Peptide Synthesis