ChemicalBook > CAS DataBase List > BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

Product Name
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
CAS No.
166410-05-5
Chemical Name
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
Synonyms
K204;Boc-4-OXO-Pro-OtBu;N-Boc-4-OXO-Pro-OtBu;N-BOC-4-oxo-L-proline t-Butyl Ester;BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;N-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;N-T-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER;(2S)-N-Boc-4-oxo-L-proline t-butyl ester;BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER USP/EP/BP;-Di-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate
CBNumber
CB3338629
Molecular Formula
C14H23NO5
Formula Weight
285.34
MOL File
166410-05-5.mol
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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Property

Melting point:
64-67°C
Boiling point:
366.7±42.0 °C(Predicted)
Density 
1.138±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
solid
pka
-3.86±0.40(Predicted)
color 
White to off-white
optical activity
10.2°(C=1g/100ml CHCL3)
InChI
InChI=1S/C14H23NO5/c1-13(2,3)19-11(17)10-7-9(16)8-15(10)12(18)20-14(4,5)6/h10H,7-8H2,1-6H3/t10-/m0/s1
InChIKey
MPNWQUWKRDADHK-JTQLQIEISA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(=O)C[C@H]1C(OC(C)(C)C)=O
LogP
2.62
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Usbiological
Product number
265614
Product name
Boc-4-oxo-L-proline tert-butyl ester
Packaging
250mg
Price
$347
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50584
Product name
Boc-4-oxo-L-proline tert-butyl ester
Packaging
100g
Price
$400
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
34742
Product name
N-Boc-4-oxo-L-prolinetert-butylester
Packaging
1g
Price
$445
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0011120
Product name
(S)-DI-TERT-BUTYL-4-OXOPYRROLIDINE-1,2-DICARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$500.09
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50584
Product name
Boc-4-oxo-L-proline tert-butyl ester
Packaging
50g
Price
$250
Updated
2021/12/16
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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

84348-37-8

75-65-0

166410-05-5

For the synthesis of di-tert-butyl (S)-4-oxopyrrolidine-1,2-dicarboxylate (16c), (S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid (16b, 1.35 g, 5.9 mmol) was dissolved in anhydrous dichloromethane (27 mL) and the solution was cooled to 0 °C. Subsequently, tert-butanol (1.7 mL, 17.7 mmol) and 4-dimethylaminopyridine (DMAP, 72 mg, 0.59 mmol) were sequentially added to the solution. After stirring for 5 min, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl, 1.19 g, 6.2 mmol) was added. The reaction mixture was gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and extracted three times with dichloromethane. The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by fast column chromatography (eluent: n-hexane/ethyl acetate, 8:1) to afford the target product 16c (0.96 g, 57% yield) as a light yellow oil.

References

[1] Tetrahedron, 1995, vol. 51, # 14, p. 4195 - 4212
[2] Patent: WO2017/53990, 2017, A1. Location in patent: Paragraph 00150

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Suppliers

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View Lastest Price from BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER manufacturers

Hebei Runbin Biotechnology Co. LTD
Product
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 166410-05-5
Price
US $100.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20tons
Release date
2020-09-14
Career Henan Chemical Co
Product
BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER 166410-05-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

166410-05-5, BOC-4-OXO-L-PROLINE TERT-BUTYL ESTERRelated Search:

N-Boc-L-lysine methyl ester hydrochloride N-Boc-D-Phenylalaninol N-Boc-D-alaninol N-BOC-L-Prolinal N-Boc-N'-Cbz-L-lysine N-Boc-4-oxo-L-Proline methyl ester 1-tert-Butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate BOC-N-ME-DL-PHG-OH BOC-D-ABU-OH N-Boc-4-oxo-L-proline 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID H-PRO-OTBU N-Boc-3-pyrrolidinone BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER Methyl 1-Methyl-2-oxopyrrolidine-3-carboxylate 4-OXO-PROLINE BOC-DL-PROLINE ETHYL ESTER N-Boc-5-aminolevulinic acid

  • BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
  • N-T-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
  • N-BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
  • 1,2-di-tert-butyl (2S)-4-oxopyrrolidine-1,2- dicarboxylate
  • (2S) tert-butyl N-(tert-butoxycabonyl)-4-oxoprolinate
  • Boc-4-OXO-Pro-OtBu
  • ditert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate
  • K204
  • -Di-tert-butyl 4-oxopyrrolidine-1,2-dicarboxylate
  • di-tert-butyl (S)-4-oxopyrrolidine-1,2-dicarboxylate
  • (2S)-1,2-Bis(tert-butoxycarbonyl)-4-oxopyrrolidine, 4-Oxo-L-proline tert-butyl ester, N-BOC protected
  • Bis(tert-butyl) (2S)-4-oxopyrrolidine-1,2-dicarboxylate
  • (2S)-4-Oxo-1,2-pyrrolidinedicarboxylic acid 1,2-bis(1,1-dimethylethyl) ester
  • N-Boc-4-OXO-Pro-OtBu
  • (2S) - 1-tert-butoxycarbonyl-4-oxo-proline tert butyl ester
  • N-BOC-4-oxo-L-proline t-Butyl Ester
  • 1,2-Pyrrolidinedicarboxylic acid, 4-oxo-, 1,2-bis(1,1-dimethylethyl) ester, (2S)-
  • (2S)-tert-Butyl-1-tert-butyloxycarbonyl-4-oxo-prolinate
  • BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER USP/EP/BP
  • (2S)-N-Boc-4-oxo-L-proline t-butyl ester
  • 166410-05-5