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N-Boc-L-tert-Leucine

Product Name
N-Boc-L-tert-Leucine
CAS No.
62965-35-9
Chemical Name
N-Boc-L-tert-Leucine
Synonyms
BOC-L-TERT-LEUCINE;BOC-TLE-OH;N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE;BOC-TLE;BOC-L-ALPHA-T-BUTYLGLYCINE;N-Boc-L-tert-leucine,99%e.e.;N-(METHOXYCARBONYL)-L-TERT-LEUCINE;BOC-L-TLE-OH;Boc-Tle-OH-d9;BOC-TBU-GLY-OH
CBNumber
CB3225606
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
62965-35-9.mol
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N-Boc-L-tert-Leucine Property

Melting point:
118-121 °C
alpha 
-4.2 º (c=1% in glacial acetic acid)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Crystalline Powder
color 
White to slightly yellow
optical activity
[α]20/D 4.2±0.5°, c = 1% in glacial acetic acid
BRN 
1962763
InChI
InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3
InChIKey
LRFZIPCTFBPFLX-SSDOTTSWSA-N
SMILES
[C@@H](C(=O)O)(C(C)(C)C)NC(=O)OC(C)(C)C |&1:0,r|
CAS DataBase Reference
62965-35-9(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
2924 19 00
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15451
Product name
Boc-Tle-OH
Purity
≥99.0% (T)
Packaging
5G
Price
$85.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53068
Product name
Boc-L-α-t-butylglycine
Purity
Novabiochem?
Packaging
5G
Price
$788
Updated
2025/07/31
Sigma-Aldrich
Product number
15451
Product name
Boc-Tle-OH
Purity
≥99.0% (T)
Packaging
25g
Price
$156
Updated
2025/07/31
TCI Chemical
Product number
B3754
Product name
N-(tert-Butoxycarbonyl)-L-tert-leucine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
B3754
Product name
N-(tert-Butoxycarbonyl)-L-tert-leucine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$239
Updated
2025/07/31
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N-Boc-L-tert-Leucine Chemical Properties,Usage,Production

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical Properties

White crystalline powder

Uses

Atazanavir Related Compound A

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

20859-02-3

24424-99-5

62965-35-9

Step A: Synthesis of N-Boc-L-tert-Leucine 1. add triethylamine (56mL, 0.4mol) to a methanol (150mL) suspension of L-tert-leucine (26.1g, 0.2mol) at 0°C. 2. slowly add di-tert-butyl dicarbonate (48g, 0.22mol) to a methanol (40mL) solution of N-Boc-L-tert-leucine. 2. a solution of di-tert-butyl dicarbonate (48 g, 0.22 mol) in methanol (40 mL) was added slowly to the above mixture, controlling the reaction temperature between 0 and 5°C. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the solvent was removed under vacuum. 5. The residue was dissolved in ethyl acetate (200 mL) and the organic layer was washed with 10% w/v aqueous citric acid (3 x 100 mL). 6. The organic layer was dried with anhydrous magnesium sulfate, filtered and the solvent was removed in vacuum to afford N-Boc-L-tert-leucine as a light yellow oil (48.9 g, yield >100% with residual solvent). Product characterization: 1H NMR (CDCl3): δ/ppm 9.20 (1H, bs, NH), 5.10 (1H, m, CH), 4.15 (1H, m, CH), 1.45 (9H, s, tert-butyl in Boc), 1.00 (9H, s, tert-butyl in tert-leucine).

References

[1] Patent: US6716878, 2004, B1. Location in patent: Page column 14
[2] Patent: US6716878, 2004, B1. Location in patent: Page column 62
[3] Patent: CN107325025, 2017, A. Location in patent: Paragraph 0086; 0087
[4] Patent: WO2005/73195, 2005, A2. Location in patent: Page/Page column 96-97
[5] Tetrahedron, 2008, vol. 64, # 18, p. 3980 - 3997

N-Boc-L-tert-Leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-L-tert-Leucine Suppliers

Americas 1 Belgium 2 Canada 1 China 366 Europe 3 France 2 Germany 10 Hungary 1 India 16 Japan 3 South Korea 1 Switzerland 7 The Netherlands 2 United Kingdom 10 United States 52 Global 477
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
Country
China
ProdList
301
Advantage
58
Shanghai Chiral Chemicals Inc.
Tel
021-37285021 13472570865
Fax
86-021-51714507
Email
tym7xi@aliyun.com
Country
China
ProdList
308
Advantage
64
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
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View Lastest Price from N-Boc-L-tert-Leucine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Boc-L-tert-Leucine 62965-35-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Henan Aochuang Chemical Co.,Ltd.
Product
N-Boc-L-tert-Leucine 62965-35-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Zibo Hangyu Biotechnology Development Co., Ltd
Product
N-Boc-L-tert-Leucine 62965-35-9
Price
US $65.00-650.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-17

62965-35-9, N-Boc-L-tert-LeucineRelated Search:

3-Aminophenol tert-Butanol ALTRENOGEST N-Carbobenzyloxyglycine L-tert-Leucine 6-Aminocaproic acid Glycine N-CARBOBENZOXY-DL-LEUCINE BOC-L-Prolinol N-Boc-L-Phenylalaninol N-Boc-L-alaninol BOC-L-NORLEUCINE Tris(hydroxymethyl)aminomethane Methoxycarbonyl-L-tert-leucine BOC-D-TERT-LEUCINE,N-BOC-D-TERT-LEUCINE (2S,4R)-N-Boc-4-hydroxy-3,3-dimethylpyrrolidine-2-carboxylic acid (S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid (S)-Boc-1-adamantyl-glycine

  • BOC-TBU-GLYCINE
  • BOC-TBU-GLY-OH
  • BOC-TLE
  • BOC-TLE-OH
  • BOC-ALPHA-BUTYLGLYCINE
  • BOC-ALPHA-T-BUTYLGLYCINE
  • BOC-ALPHA-T-BUTYLGLYCINE-OH
  • BOC-ALPHA-T-BUTYL-GLY-OH
  • BOC-L-TLE-OH
  • BOC-L-T-BUTYLGLYCINE
  • BOC-L-TERT-LEUCINE
  • BOC-L-ALPHA-T-BUTYLGLYCINE
  • RARECHEM EM WB 0082
  • (S)-N-(TERT-BUTOXYCARBONYL)-TERT-LEUCINE
  • (S)-N-BOC-2-AMINO-3,3-DIMETHYLBUTYRIC ACID
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-TERT-BUTYLGLYCINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-T-LEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-ALPHA-T-BUTYL-GLYCINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-T-BUTYLGLYCINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-T-LEUCINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-T-LEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID
  • N-ALPHA-T-BOC-L-T-LEUCINE
  • N-ALPHA-T-BOC-L-ALPHA-T-BUTYL-GLYCINE
  • N-BOC-(L)-T-LEUCINE
  • N-BOC-L-TERT-LEUCINE
  • N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE
  • N-(METHOXYCARBONYL)-L-TERT-LEUCINE
  • L-Valine, N-(1,1-dimethylethoxy)carbonyl-3-methyl-
  • BOC-L-T-LEUCINE
  • Boc-L-α-tert-butylglycine≥ 98% (HPLC)
  • Boc-L-α-tert-butyl-Gly-OH
  • N-Boc-L-tert-leucine,99%e.e.
  • Boc-L-α-t-butylglycine Novabiochem
  • (Tert-Butoxy)Carbonyl Tle-OH
  • Boc-Tle-OH-d9
  • BOC-L-2-AMINO-3,3-DIMETHYLBUTANOIC ACID
  • N-alpha-t-Butyloxycarbonyl-L-t-leucine, N-alpha-t-Butyloxycarbonyl-L-t-butylglycine
  • Boc--t-Butylglycine
  • (S)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoic a
  • BOC-L-TERT-BUTYLGLYCINE
  • (S)-N-Boc-2-amino-3,3-dimethylbutyric acid, Boc-L-tert-leucine
  • Boc-a-tert-Butyl-Gly-OH
  • N-BOC-L-tert-Leucine,98%
  • N-BOC-L-tert-LeucineN-(tert-Butoxycarbonyl)-L-leucine
  • Boc-Tle-OH (Boc-tertleucine)
  • N-BOC-L-tert-Leucine, 98% 5GR
  • (2S)-2-(tert-ButoxycarbonylaMino)-3,3-diMethylbutanoic Acid
  • (S)-2-(((tert-Butoxy)carbonyl)aMino)-3,3-diMethylbutanoic Acid
  • (S)-2-tert-ButoxycarbonylaMino-3,3-diMethylbutyric Acid
  • N-tert-Butoxyc
  • (S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric Acid (S)-2-(Boc-amino)-3,3-dimethylbutyric Acid N-Boc-L-tert-leucine Boc-Tle-OH
  • BOC-L-tert-Leucine,Boc-Alpha-ButylGlycine
  • N-(tert-Butoxycarbonyl)-L-tert-leucine &gt
  • Boc-Tle-OH Boc-?-tert-butyl-Gly-OH
  • (S)-2-(Boc-amino)-3,3-dimethylbutyric Acid
  • N-Boc-L-tert-Leucine USP/EP/BP
  • Boc-L-α-tert-butylglycine