ChemicalBook > CAS DataBase List > N-Boc-L-tert-Leucine

N-Boc-L-tert-Leucine

Product Name: N-Boc-L-tert-Leucine
CAS No.: 62965-35-9
Chemical Name: N-Boc-L-tert-Leucine
Synonyms: BOC-L-TERT-LEUCINE;BOC-TLE-OH;N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE;BOC-TLE;BOC-L-ALPHA-T-BUTYLGLYCINE;N-Boc-L-tert-leucine,99%e.e.;N-(METHOXYCARBONYL)-L-TERT-LEUCINE;BOC-L-TLE-OH;Boc-Tle-OH-d9;BOC-TBU-GLY-OH
CBNumber: CB3225606
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 62965-35-9.mol

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N-Boc-L-tert-Leucine Property

Melting point:: 118-121 °C
alpha: -4.2 º (c=1% in glacial acetic acid)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Crystalline Powder
color: White to slightly yellow
optical activity: [α]20/D 4.2±0.5°, c = 1% in glacial acetic acid
BRN: 1962763
InChI: InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3
InChIKey: LRFZIPCTFBPFLX-SSDOTTSWSA-N
SMILES: [C@@H](C(=O)O)(C(C)(C)C)NC(=O)OC(C)(C)C |&1:0,r|
CAS DataBase Reference: 62965-35-9(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 2924 19 00
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15451
Product name: Boc-Tle-OH
Purity: ≥99.0% (T)
Packaging: 5G
Price: $85.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53068
Product name: Boc-L-α-t-butylglycine
Purity: Novabiochem?
Packaging: 5G
Price: $788
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15451
Product name: Boc-Tle-OH
Purity: ≥99.0% (T)
Packaging: 25g
Price: $156
Updated: 2025/07/31

TCI Chemical

Product number: B3754
Product name: N-(tert-Butoxycarbonyl)-L-tert-leucine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B3754
Product name: N-(tert-Butoxycarbonyl)-L-tert-leucine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $239
Updated: 2025/07/31

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N-Boc-L-tert-Leucine Chemical Properties,Usage,Production

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical Properties

White crystalline powder

Uses

Atazanavir Related Compound A

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

20859-02-3

24424-99-5

62965-35-9

Step A: Synthesis of N-Boc-L-tert-Leucine 1. add triethylamine (56mL, 0.4mol) to a methanol (150mL) suspension of L-tert-leucine (26.1g, 0.2mol) at 0°C. 2. slowly add di-tert-butyl dicarbonate (48g, 0.22mol) to a methanol (40mL) solution of N-Boc-L-tert-leucine. 2. a solution of di-tert-butyl dicarbonate (48 g, 0.22 mol) in methanol (40 mL) was added slowly to the above mixture, controlling the reaction temperature between 0 and 5°C. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the solvent was removed under vacuum. 5. The residue was dissolved in ethyl acetate (200 mL) and the organic layer was washed with 10% w/v aqueous citric acid (3 x 100 mL). 6. The organic layer was dried with anhydrous magnesium sulfate, filtered and the solvent was removed in vacuum to afford N-Boc-L-tert-leucine as a light yellow oil (48.9 g, yield >100% with residual solvent). Product characterization: 1H NMR (CDCl3): δ/ppm 9.20 (1H, bs, NH), 5.10 (1H, m, CH), 4.15 (1H, m, CH), 1.45 (9H, s, tert-butyl in Boc), 1.00 (9H, s, tert-butyl in tert-leucine).

References

[1] Patent: US6716878, 2004, B1. Location in patent: Page column 14
[2] Patent: US6716878, 2004, B1. Location in patent: Page column 62
[3] Patent: CN107325025, 2017, A. Location in patent: Paragraph 0086; 0087
[4] Patent: WO2005/73195, 2005, A2. Location in patent: Page/Page column 96-97
[5] Tetrahedron, 2008, vol. 64, # 18, p. 3980 - 3997

N-Boc-L-tert-Leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-L-tert-Leucine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Boc-L-tert-Leucine 62965-35-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: N-Boc-L-tert-Leucine 62965-35-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Zibo Hangyu Biotechnology Development Co., Ltd

Product: N-Boc-L-tert-Leucine 62965-35-9
Price: US $65.00-650.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-17

62965-35-9, N-Boc-L-tert-LeucineRelated Search:

3-Aminophenol tert-Butanol ALTRENOGEST N-Carbobenzyloxyglycine L-tert-Leucine 6-Aminocaproic acid Glycine N-CARBOBENZOXY-DL-LEUCINE BOC-L-Prolinol N-Boc-L-Phenylalaninol N-Boc-L-alaninol BOC-L-NORLEUCINE Tris(hydroxymethyl)aminomethane Methoxycarbonyl-L-tert-leucine BOC-D-TERT-LEUCINE,N-BOC-D-TERT-LEUCINE (2S,4R)-N-Boc-4-hydroxy-3,3-dimethylpyrrolidine-2-carboxylic acid (S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid (S)-Boc-1-adamantyl-glycine

BOC-TBU-GLYCINE

BOC-TBU-GLY-OH

BOC-TLE

BOC-TLE-OH

BOC-ALPHA-BUTYLGLYCINE

BOC-ALPHA-T-BUTYLGLYCINE

BOC-ALPHA-T-BUTYLGLYCINE-OH

BOC-ALPHA-T-BUTYL-GLY-OH

BOC-L-TLE-OH

BOC-L-T-BUTYLGLYCINE

BOC-L-TERT-LEUCINE

BOC-L-ALPHA-T-BUTYLGLYCINE

RARECHEM EM WB 0082

(S)-N-(TERT-BUTOXYCARBONYL)-TERT-LEUCINE

(S)-N-BOC-2-AMINO-3,3-DIMETHYLBUTYRIC ACID

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-TERT-BUTYLGLYCINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-T-LEUCINE

N-ALPHA-T-BUTOXYCARBONYL-L-ALPHA-T-BUTYL-GLYCINE

N-ALPHA-T-BUTOXYCARBONYL-L-T-BUTYLGLYCINE

N-ALPHA-T-BUTOXYCARBONYL-L-T-LEUCINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-T-LEUCINE

N-ALPHA-T-BUTOXYCARBONYL-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID

N-ALPHA-T-BOC-L-T-LEUCINE

N-ALPHA-T-BOC-L-ALPHA-T-BUTYL-GLYCINE

N-BOC-(L)-T-LEUCINE

N-BOC-L-TERT-LEUCINE

N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE

N-(METHOXYCARBONYL)-L-TERT-LEUCINE

L-Valine, N-(1,1-dimethylethoxy)carbonyl-3-methyl-

BOC-L-T-LEUCINE

Boc-L-α-tert-butylglycine≥ 98% (HPLC)

Boc-L-α-tert-butyl-Gly-OH

N-Boc-L-tert-leucine,99%e.e.

Boc-L-α-t-butylglycine Novabiochem

(Tert-Butoxy)Carbonyl Tle-OH

Boc-Tle-OH-d9

BOC-L-2-AMINO-3,3-DIMETHYLBUTANOIC ACID

N-alpha-t-Butyloxycarbonyl-L-t-leucine, N-alpha-t-Butyloxycarbonyl-L-t-butylglycine

Boc--t-Butylglycine

(S)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoic a

BOC-L-TERT-BUTYLGLYCINE

(S)-N-Boc-2-amino-3,3-dimethylbutyric acid, Boc-L-tert-leucine

Boc-a-tert-Butyl-Gly-OH

N-BOC-L-tert-Leucine,98%

N-BOC-L-tert-LeucineN-(tert-Butoxycarbonyl)-L-leucine

Boc-Tle-OH (Boc-tertleucine)

N-BOC-L-tert-Leucine, 98% 5GR

(2S)-2-(tert-ButoxycarbonylaMino)-3,3-diMethylbutanoic Acid

(S)-2-(((tert-Butoxy)carbonyl)aMino)-3,3-diMethylbutanoic Acid

(S)-2-tert-ButoxycarbonylaMino-3,3-diMethylbutyric Acid

N-tert-Butoxyc

(S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric Acid (S)-2-(Boc-amino)-3,3-dimethylbutyric Acid N-Boc-L-tert-leucine Boc-Tle-OH

BOC-L-tert-Leucine,Boc-Alpha-ButylGlycine

N-(tert-Butoxycarbonyl)-L-tert-leucine &gt

Boc-Tle-OH Boc-?-tert-butyl-Gly-OH

(S)-2-(Boc-amino)-3,3-dimethylbutyric Acid

N-Boc-L-tert-Leucine USP/EP/BP

Boc-L-α-tert-butylglycine