ChemicalBook > CAS DataBase List > (+)-Bicuculline

(+)-Bicuculline

Product Name
(+)-Bicuculline
CAS No.
485-49-4
Chemical Name
(+)-Bicuculline
Synonyms
NSC 3219;bicucullin;NSC 32192);Bucuculline;BICUCULLINE;D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline,98%
CBNumber
CB3418662
Molecular Formula
C20H17NO6
Formula Weight
367.35
MOL File
485-49-4.mol
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(+)-Bicuculline Property

Melting point:
193-197 °C
alpha 
D25 +130.5° (CHCl3)
Boiling point:
497.92°C (rough estimate)
Density 
1.3694 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
2-8°C
pka
4.84(at 25℃)
form 
Off-white to yellow powder.
optical activity
[α]20/D +126±6°, c = 1% in chloroform
λmax
325nm(lit.)
Merck 
14,1203
BRN 
98786
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference
485-49-4(CAS DataBase Reference)
EPA Substance Registry System
Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
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Safety

Hazard Codes 
T,N,Xn
Risk Statements 
23/24/25-50-36/37/38-20/21/22
Safety Statements 
36/37-45-61-36-26
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
LV0909840
10-23
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29399990
Toxicity
LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H401Toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
14340
Product name
(+)-Bicuculline
Purity
≥97.0% (TLC)
Packaging
25mg
Price
$64.8
Updated
2021/03/22
Sigma-Aldrich
Product number
14340
Product name
(+)-Bicuculline
Purity
≥97.0% (TLC)
Packaging
100mg
Price
$100
Updated
2021/03/22
TCI Chemical
Product number
B1890
Product name
(+)-Bicuculline
Purity
>98.0%(HPLC)(T)
Packaging
25mg
Price
$54
Updated
2021/03/22
TCI Chemical
Product number
B1890
Product name
(+)-Bicuculline
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$160
Updated
2021/03/22
Cayman Chemical
Product number
11727
Product name
Bicuculline
Purity
≥98%
Packaging
50mg
Price
$35
Updated
2021/03/22
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(+)-Bicuculline Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

GABAA receptor antagonist.

Uses

GABAa antagonist

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

Biological Activity

Classical GABA A antagonist.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

(+)-Bicuculline Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-Bicuculline Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Email
sales@dongfan-chem.com
Country
China
ProdList
5702
Advantage
66
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
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View Lastest Price from (+)-Bicuculline manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
(+)-Bicuculline 485-49-4
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 tons/months
Release date
2021-07-12
Shaanxi Dideu Medichem Co. Ltd
Product
(+)-Bicuculline 485-49-4
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Dideu Industries Group Limited
Product
(+)-Bicuculline USP/EP/BP 485-49-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-16

485-49-4, (+)-BicucullineRelated Search:


  • 5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo(
  • bicucullin
  • Bucuculline
  • d-Bicuculline/(+)-Bicuculline
  • D-alkali than buttoned Spirit
  • Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-
  • 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one
  • (+)-Bicuculline, 99%, a GABAA antagonist
  • Hutchison Agar Medium
  • furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo
  • (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
  • NSC 3219
  • NSC 32192)
  • (6R)-6-[(5S)-6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one
  • 1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv.
  • Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))-
  • (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
  • (+)-Bicuculline,98%
  • PLUS-BICUCULLINE
  • (+)-BICUCULLINE 1(S),9(R)
  • (r-(r*,s*))-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6h)-one
  • [R-(R*,S*)]-6-(5,6,7,8-TETRAHYDRO-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)FURO[3,4-E]-1,3-BENZODIOXOL-8(6H)-ONE
  • (+)-BICUCULINE
  • (+)-BICUCULLINE
  • BICUCULLINE
  • D-BICUCULLINE
  • BICUCULLINE, (+)-(P)
  • (+)-Bicuculline &gt
  • (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one
  • (+)-Bicuculline USP/EP/BP
  • (+) bicuculline DISCONTINUED, offer B382500
  • 485-49-4
  • C20H17NO6
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • GABA/Glycine receptor
  • GABA