TEMAFLOXACIN

Product Name: TEMAFLOXACIN
CAS No.: 108319-06-8
Chemical Name: TEMAFLOXACIN
Synonyms: Teflox;A-63004;A-62254;Omniflox;AKOS 92085;TEMAFLOXACIN;TeMafloxacin HCl;TEMAFLOXACIN USP/EP/BP;Temafloxacin (Omniflox);6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CBNumber: CB4244763
Molecular Formula: C21H18F3N3O3
Formula Weight: 417.38
MOL File: 108319-06-8.mol

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TEMAFLOXACIN Property

Melting point:: >200°C (dec.)
Boiling point:: 608.9±55.0 °C(Predicted)
Density: 1.3372 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 6.02±0.41(Predicted)
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
InChIKey: QKDHBVNJCZBTMR-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(F)C=C2F)C2=C(C=C(F)C(N3CCNC(C)C3)=C2)C(=O)C(C(O)=O)=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17352
Product name: Temafloxacin
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17352
Product name: Temafloxacin
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 17352
Product name: Temafloxacin
Packaging: 10mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17352
Product name: Temafloxacin
Packaging: 25mg
Price: $321
Updated: 2024/03/01

TRC

Product number: T017185
Product name: Temafloxacin
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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TEMAFLOXACIN Chemical Properties,Usage,Production

Description

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

Chemical Properties

Crystallizes in ethanol, melting point 274-276℃.

Uses

Antibacterial (microbial DNA topoisomerase inhibitor).

Uses

Temafloxacin is an antimicrobial quinolone drug.

Definition

ChEBI: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively. It is a quinolone, an amino acid, a monocarboxylic acid, an organofluorine compound, a secondary amino compound, a tertiary amino compound, a N-arylpiperazine and a quinolone antibiotic.

brand name

Omniflox (Abbott);8Omniflox 8Teflox 8Temac.

World Health Organization (WHO)

Temafloxacin, a quinolone antimicrobial, was introduced in 1991. Shortly afterwards, its use became associated with severe adverse effects, including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.

References

[1] M.D. G A P. Temafloxacin: An overview[J]. American Journal of Medicine, 1991, 91 6: Pages S166-S172. DOI: 10.1016/0002-9343(91)90332-r

TEMAFLOXACIN Preparation Products And Raw materials

Raw materials

Sodium hydride 2-Methylpiperazine 2,4-Dichloro-5-fluoroacetophenone 2,4-Difluoroaniline Diethyl carbonate 1,2-Dimethoxyethane

Preparation Products

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TEMAFLOXACIN Suppliers

China 45 Germany 1 India 2 United Kingdom 4 United States 11 Global 63

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1839
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: sales@uhnshanghai.com
Country: China
ProdList: 1984
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

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View Lastest Price from TEMAFLOXACIN manufacturers

Dideu Industries Group Limited

Product: TEMAFLOXACIN 108319-06-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-19

108319-06-8, TEMAFLOXACINRelated Search:

Cisapride Sarafloxacin 4'-PIPERAZINOACETOPHENONE TEMAFLOXACIN 4-FLUORODIPHENYLAMINE AKOS 90679 DESETHYLENE CIPROFLOXACIN 2-FLUORODIPHENYLAMINE TEMAFLOXACIN HYDROCHLORIDE Piperazine, 3-methyl-1-phenyl- (9CI) Benzenamine, 3-(1-piperazinyl)- (9CI)

Teflox

6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

TeMafloxacin HCl

TEMAFLOXACIN

AKOS 92085

1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl) -4-oxo-3-quinoline-carboxylic acid

1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid hydrochloride

A-62254

A-63004

Omniflox

TEMAFLOXACIN USP/EP/BP

Temafloxacin (Omniflox)

3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-

S. aureus,gram-negative,Temafloxacin,Antibiotic,anaerobic,murine pyelonephritis,gram-positive,Bacterial,TMFX,TA167,P. aeruginosa,TA 167,A-62254,TA-167,Inhibitor,E. coli,inhibit,A 62254,A62254

108319-06-8

C21H19ClF3N3O3

C21H18F3N3O3