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TEMAFLOXACIN

Product Name
TEMAFLOXACIN
CAS No.
108319-06-8
Chemical Name
TEMAFLOXACIN
Synonyms
Teflox;A-63004;A-62254;Omniflox;AKOS 92085;TEMAFLOXACIN;TeMafloxacin HCl;TEMAFLOXACIN USP/EP/BP;Temafloxacin (Omniflox);6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CBNumber
CB4244763
Molecular Formula
C21H18F3N3O3
Formula Weight
417.38
MOL File
108319-06-8.mol
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TEMAFLOXACIN Property

Melting point:
>200°C (dec.)
Boiling point:
608.9±55.0 °C(Predicted)
Density 
1.3372 (estimate)
storage temp. 
2-8°C(protect from light)
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.02±0.41(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
InChIKey
QKDHBVNJCZBTMR-UHFFFAOYSA-N
SMILES
N1(C2=CC=C(F)C=C2F)C2=C(C=C(F)C(N3CCNC(C)C3)=C2)C(=O)C(C(O)=O)=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17352
Product name
Temafloxacin
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17352
Product name
Temafloxacin
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
17352
Product name
Temafloxacin
Packaging
10mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
17352
Product name
Temafloxacin
Packaging
25mg
Price
$321
Updated
2024/03/01
TRC
Product number
T017185
Product name
Temafloxacin
Packaging
1mg
Price
$50
Updated
2021/12/16
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TEMAFLOXACIN Chemical Properties,Usage,Production

Description

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

Chemical Properties

Crystallizes in ethanol, melting point 274-276℃.

Uses

Antibacterial (microbial DNA topoisomerase inhibitor).

Uses

Temafloxacin is an antimicrobial quinolone drug.

Definition

ChEBI: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively. It is a quinolone, an amino acid, a monocarboxylic acid, an organofluorine compound, a secondary amino compound, a tertiary amino compound, a N-arylpiperazine and a quinolone antibiotic.

brand name

Omniflox (Abbott);8Omniflox 8Teflox 8Temac.

World Health Organization (WHO)

Temafloxacin, a quinolone antimicrobial, was introduced in 1991. Shortly afterwards, its use became associated with severe adverse effects, including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.

References

[1] M.D. G A P. Temafloxacin: An overview[J]. American Journal of Medicine, 1991, 91 6: Pages S166-S172. DOI: 10.1016/0002-9343(91)90332-r

TEMAFLOXACIN Preparation Products And Raw materials

Raw materials

Sodium hydride 2-Methylpiperazine 2,4-Dichloro-5-fluoroacetophenone 2,4-Difluoroaniline Diethyl carbonate 1,2-Dimethoxyethane

Preparation Products

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View Lastest Price from TEMAFLOXACIN manufacturers

Dideu Industries Group Limited
Product
TEMAFLOXACIN 108319-06-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-19

108319-06-8, TEMAFLOXACINRelated Search:

Cisapride Sarafloxacin 4'-PIPERAZINOACETOPHENONE TEMAFLOXACIN 4-FLUORODIPHENYLAMINE AKOS 90679 DESETHYLENE CIPROFLOXACIN 2-FLUORODIPHENYLAMINE TEMAFLOXACIN HYDROCHLORIDE Piperazine, 3-methyl-1-phenyl- (9CI) Benzenamine, 3-(1-piperazinyl)- (9CI)

  • Teflox
  • 6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • TeMafloxacin HCl
  • TEMAFLOXACIN
  • AKOS 92085
  • 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl) -4-oxo-3-quinoline-carboxylic acid
  • 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid hydrochloride
  • A-62254
  • A-63004
  • Omniflox
  • TEMAFLOXACIN USP/EP/BP
  • Temafloxacin (Omniflox)
  • 3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
  • S. aureus,gram-negative,Temafloxacin,Antibiotic,anaerobic,murine pyelonephritis,gram-positive,Bacterial,TMFX,TA167,P. aeruginosa,TA 167,A-62254,TA-167,Inhibitor,E. coli,inhibit,A 62254,A62254
  • 108319-06-8
  • C21H19ClF3N3O3
  • C21H18F3N3O3