4'-PIPERAZINOACETOPHENONE

Product Name: 4'-PIPERAZINOACETOPHENONE
CAS No.: 51639-48-6
Chemical Name: 4'-PIPERAZINOACETOPHENONE
Synonyms: Ethanone, 1-[4-(1-piperazinyl)phenyl]-;NSC 109890;BUTTPARK 62\14-24;LABOTEST-BB LT00138218;-Piperazinoacetophenone;4-PIPERAZINEACETOPHENONE;4-PIPERAZINOACETOPHENONE;p-Piperazinoacetophenone;4'-PIPERAZINOACETOPHENONE;4-PIPERAZINEOACETOPHENONE
CBNumber: CB2413837
Molecular Formula: C12H16N2O
Formula Weight: 204.27
MOL File: 51639-48-6.mol

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4'-PIPERAZINOACETOPHENONE Property

Melting point:: 107-110 °C(lit.)
Boiling point:: 342.77°C (rough estimate)
Density: 1.0565 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: 2-8°C
solubility: Benzene (Slightly, Heated), Chloroform (Slightly), DMSO (Slightly, Heated)
pka: 8.80±0.10(Predicted)
form: Powder or Chunks
color: Yellow
CAS DataBase Reference: 51639-48-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-34-21/22
Safety Statements: 26-37/39
RIDADR: 3259
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 136468
Product name: 4′-Piperazinoacetophenone
Purity: 94%
Packaging: 5g
Price: $78
Updated: 2023/01/07

TRC

Product number: P481240
Product name: 1-[4-(1-Piperazinyl)phenyl]ethanone
Packaging: 2.5g
Price: $55
Updated: 2021/12/16

TRC

Product number: P481240
Product name: 1-[4-(1-Piperazinyl)phenyl]ethanone
Packaging: 5g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR0219
Product name: 4'-(Piperazin-1-yl)acetophenone
Packaging: 5g
Price: $67
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-1-23
Product name: 1-[4-(Piperazin-1-yl)phenyl]ethan-1-one
Purity: 96.0%
Packaging: 25g
Price: $197
Updated: 2021/12/16

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4'-PIPERAZINOACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

yellow powder or chunks

Uses

1-[4-(1-Piperazinyl)phenyl]ethanone is a useful building block for organic synthesis.

Synthesis

110-85-0

403-42-9

51639-48-6

1. Potassium carbonate (2.99 g, 21.6 mmol) was placed in a round-bottomed flask and dried under vacuum with a hot air gun. 2. Tetrabutylammonium bromide (0.045 g, 0.14 mmol) and piperazine (1.54 g, 17.9 mmol) dissolved in anhydrous dimethyl sulfoxide (5 mL) were added sequentially. 3. The reaction mixture was stirred at 80 °C, followed by the addition of 4-fluoroacetophenone (2 g, 14.4 mmol) and the reaction was refluxed for 15 h at the same temperature. 4. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and the solid was collected by filtration. 5. The filtrate was acidified with dilute hydrochloric acid and subsequently extracted with ethyl acetate. 6. The aqueous layer was alkalized with sodium hydroxide and extracted with chloroform. 7. The chloroform layers were combined, dried over anhydrous sodium sulfate and concentrated to give the light yellow solid product 4'-piperazineacetophenone (2.23 g, 75.25% yield, melting point 109°C). 8. The product was analyzed by 1H NMR. 8. The product was characterized by 1H NMR (200 MHz, CDCl3): δ 1.91 (s, 1H), 2.52 (s, 3H), 2.98-3.05 (m, 4H), 3.28-3.35 (m, 4H), 6.87 (d, J = 8.8 Hz, 2H), 7.87 (d, J = 8.8 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5507 - 5520
[2] Patent: WO2014/132267, 2014, A1. Location in patent: Page/Page column 33
[3] Patent: WO2005/7637, 2005, A1. Location in patent: Page 7-8

4'-PIPERAZINOACETOPHENONE Preparation Products And Raw materials

Raw materials

Sodium chloride Potassium carbonate Piperazine 4-Fluoroacetophenone Dichloromethane Dimethyl sulfoxide Magnesium sulfate

Preparation Products

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4'-PIPERAZINOACETOPHENONE Suppliers

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51639-48-6, 4'-PIPERAZINOACETOPHENONERelated Search:

Piperazine Lomefloxacin Vebufloxacin 4'-PIPERAZINOACETOPHENONE Enrofloxacin Danofloxacin mesylate Norfloxacin Ciprofloxacin hydrochloride hydrate Levofloxacin Ciprofloxacin TEMAFLOXACIN Marbofloxacin 1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-1-ETHANONE 1-[4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYL]-ETHANONE [3-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-OXOPROPYLIDENE](METHYL)AMMONIUMOLATE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-(METHYL[(4-METHYLBENZOYL)OXY]AMINO)-2-PROPEN-1-ONE

4-Piperazinoacetophenone, 94% 25GR

1-(4-Acetylphenyl)piperazine, 1-[4-(Piperazin-1-yl)phenyl]ethan-1-one

N-(4-Acetylphenyl)piperazine

NSC 109890

BUTTPARK 62\14-24

LABOTEST-BB LT00138218

4'-(PIPERAZIN-4-YL)ACETOPHENONE

4'-PIPERAZINOACETOPHENONE

4-PIPERAZINOACETOPHENONE

4-PIPERAZINEACETOPHENONE

1-(4-Piperazin-1-yl-phenyl)-ethanone ,96%

p-(1-Piperazinyl)acetophenone

p-Piperazinoacetophenone

4-Piperazinoacetophenone,94%

4'-(Piperazin-1-yl)acetophenone

1-(4-PIPERAZIN-1-YL-PHENYL)ETHANONE

1-(4-ACETYLPHENYL)PIPERAZINE

piperazin-4-ylacetophenone

4’-(1-Piperazino)acetophenone

4'-(1-piperazino)acetophenone, tech.

1-(4-Acetylphenyl)piperazine 96%

4-PIPERAZINEOACETOPHENONE

1-[4-(1-piperazin-4-iumyl)phenyl]ethanone

Ethanone, 1-[4-(1-piperazinyl)phenyl]-

1-[4-(1-Piperazinyl)phenyl]ethanone

1-(4-Piperazin-1-yl-phenyl)-ethano

-Piperazinoacetophenone

1-(4-(Piperazin-1-yl)phenyl)ethan-1-one - [P3194]

51639-48-6

C12H16N2O

KETONE

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