ChemicalBook > CAS DataBase List > 4'-PIPERAZINOACETOPHENONE

4'-PIPERAZINOACETOPHENONE

Product Name
4'-PIPERAZINOACETOPHENONE
CAS No.
51639-48-6
Chemical Name
4'-PIPERAZINOACETOPHENONE
Synonyms
Ethanone, 1-[4-(1-piperazinyl)phenyl]-;NSC 109890;BUTTPARK 62\14-24;LABOTEST-BB LT00138218;-Piperazinoacetophenone;4-PIPERAZINEACETOPHENONE;4-PIPERAZINOACETOPHENONE;p-Piperazinoacetophenone;4'-PIPERAZINOACETOPHENONE;4-PIPERAZINEOACETOPHENONE
CBNumber
CB2413837
Molecular Formula
C12H16N2O
Formula Weight
204.27
MOL File
51639-48-6.mol
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4'-PIPERAZINOACETOPHENONE Property

Melting point:
107-110 °C(lit.)
Boiling point:
342.77°C (rough estimate)
Density 
1.0565 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Benzene (Slightly, Heated), Chloroform (Slightly), DMSO (Slightly, Heated)
pka
8.80±0.10(Predicted)
form 
Powder or Chunks
color 
Yellow
CAS DataBase Reference
51639-48-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-34-21/22
Safety Statements 
26-37/39
RIDADR 
3259
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
8
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
136468
Product name
4′-Piperazinoacetophenone
Purity
94%
Packaging
5g
Price
$78
Updated
2023/01/07
TRC
Product number
P481240
Product name
1-[4-(1-Piperazinyl)phenyl]ethanone
Packaging
2.5g
Price
$55
Updated
2021/12/16
TRC
Product number
P481240
Product name
1-[4-(1-Piperazinyl)phenyl]ethanone
Packaging
5g
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR0219
Product name
4'-(Piperazin-1-yl)acetophenone
Packaging
5g
Price
$67
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-1-23
Product name
1-[4-(Piperazin-1-yl)phenyl]ethan-1-one
Purity
96.0%
Packaging
25g
Price
$197
Updated
2021/12/16
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4'-PIPERAZINOACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

yellow powder or chunks

Uses

1-[4-(1-Piperazinyl)phenyl]ethanone is a useful building block for organic synthesis.

Synthesis

110-85-0

403-42-9

51639-48-6

1. Potassium carbonate (2.99 g, 21.6 mmol) was placed in a round-bottomed flask and dried under vacuum with a hot air gun. 2. Tetrabutylammonium bromide (0.045 g, 0.14 mmol) and piperazine (1.54 g, 17.9 mmol) dissolved in anhydrous dimethyl sulfoxide (5 mL) were added sequentially. 3. The reaction mixture was stirred at 80 °C, followed by the addition of 4-fluoroacetophenone (2 g, 14.4 mmol) and the reaction was refluxed for 15 h at the same temperature. 4. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and the solid was collected by filtration. 5. The filtrate was acidified with dilute hydrochloric acid and subsequently extracted with ethyl acetate. 6. The aqueous layer was alkalized with sodium hydroxide and extracted with chloroform. 7. The chloroform layers were combined, dried over anhydrous sodium sulfate and concentrated to give the light yellow solid product 4'-piperazineacetophenone (2.23 g, 75.25% yield, melting point 109°C). 8. The product was analyzed by 1H NMR. 8. The product was characterized by 1H NMR (200 MHz, CDCl3): δ 1.91 (s, 1H), 2.52 (s, 3H), 2.98-3.05 (m, 4H), 3.28-3.35 (m, 4H), 6.87 (d, J = 8.8 Hz, 2H), 7.87 (d, J = 8.8 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5507 - 5520
[2] Patent: WO2014/132267, 2014, A1. Location in patent: Page/Page column 33
[3] Patent: WO2005/7637, 2005, A1. Location in patent: Page 7-8

4'-PIPERAZINOACETOPHENONE Preparation Products And Raw materials

Raw materials

Sodium chloride Potassium carbonate Piperazine 4-Fluoroacetophenone Dichloromethane Dimethyl sulfoxide Magnesium sulfate

Preparation Products

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51639-48-6, 4'-PIPERAZINOACETOPHENONERelated Search:

Piperazine Lomefloxacin Vebufloxacin 4'-PIPERAZINOACETOPHENONE Enrofloxacin Danofloxacin mesylate Norfloxacin Ciprofloxacin hydrochloride hydrate Levofloxacin Ciprofloxacin TEMAFLOXACIN Marbofloxacin 1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-1-ETHANONE 1-[4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYL]-ETHANONE [3-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-OXOPROPYLIDENE](METHYL)AMMONIUMOLATE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE 1-(4-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)PHENYL)-3-(METHYL[(4-METHYLBENZOYL)OXY]AMINO)-2-PROPEN-1-ONE

  • 4-Piperazinoacetophenone, 94% 25GR
  • 1-(4-Acetylphenyl)piperazine, 1-[4-(Piperazin-1-yl)phenyl]ethan-1-one
  • N-(4-Acetylphenyl)piperazine
  • NSC 109890
  • BUTTPARK 62\14-24
  • LABOTEST-BB LT00138218
  • 4'-(PIPERAZIN-4-YL)ACETOPHENONE
  • 4'-PIPERAZINOACETOPHENONE
  • 4-PIPERAZINOACETOPHENONE
  • 4-PIPERAZINEACETOPHENONE
  • 1-(4-Piperazin-1-yl-phenyl)-ethanone ,96%
  • p-(1-Piperazinyl)acetophenone
  • p-Piperazinoacetophenone
  • 4-Piperazinoacetophenone,94%
  • 4'-(Piperazin-1-yl)acetophenone
  • 1-(4-PIPERAZIN-1-YL-PHENYL)ETHANONE
  • 1-(4-ACETYLPHENYL)PIPERAZINE
  • piperazin-4-ylacetophenone
  • 4’-(1-Piperazino)acetophenone
  • 4'-(1-piperazino)acetophenone, tech.
  • 1-(4-Acetylphenyl)piperazine 96%
  • 4-PIPERAZINEOACETOPHENONE
  • 1-[4-(1-piperazin-4-iumyl)phenyl]ethanone
  • Ethanone, 1-[4-(1-piperazinyl)phenyl]-
  • 1-[4-(1-Piperazinyl)phenyl]ethanone
  • 1-(4-Piperazin-1-yl-phenyl)-ethano
  • -Piperazinoacetophenone
  • 1-(4-(Piperazin-1-yl)phenyl)ethan-1-one - [P3194]
  • 51639-48-6
  • C12H16N2O
  • KETONE
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