2,4-Dichloro-5-fluoroacetophenone
Application- Product Name
- 2,4-Dichloro-5-fluoroacetophenone
- CAS No.
- 704-10-9
- Chemical Name
- 2,4-Dichloro-5-fluoroacetophenone
- Synonyms
- 2,4-Dichloro-5-fluor;2,4-dichloro-5-fluoroben;Ciprofloxacin Impurity 18;2',4'-Dichloro-5'-Fluoroacet;2,4- Dichloro -5-fluorohypnone;2,4-DICHLORO-5-FLUOROACETOPHENONE;2,4-Dichloro-5-flouroacetophenone;2,4-Dichloro-5-fluorobenzophenone;2',4'-DICHLORO-5'-FLUOROACETOPHENONE;2,4- twochlorine-5- fluoroAcetophenone
- CBNumber
- CB6118080
- Molecular Formula
- C8H5Cl2FO
- Formula Weight
- 207.03
- MOL File
- 704-10-9.mol
2,4-Dichloro-5-fluoroacetophenone Property
- Melting point:
- 33-36 °C
- Boiling point:
- 167 °C(lit.)
- Density
- 1.425 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.546(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- Specific Gravity
- 1.425
- BRN
- 3090042
- InChI
- InChI=1S/C8H5Cl2FO/c1-4(12)5-2-8(11)7(10)3-6(5)9/h2-3H,1H3
- InChIKey
- FAKJFAMIABOKBW-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(F)=C(Cl)C=C1Cl)C
- CAS DataBase Reference
- 704-10-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Flammable
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 457345
- Product name
- 2′,4′-Dichloro-5′-fluoroacetophenone
- Purity
- 90%
- Packaging
- 5g
- Price
- $30
- Updated
- 2023/06/20
- Product number
- D2385
- Product name
- 2',4'-Dichloro-5'-fluoroacetophenone
- Packaging
- 25g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- D438723
- Product name
- 2'',4''-Dichloro-5''-fluoroacetophenone
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D438723
- Product name
- 2'',4''-Dichloro-5''-fluoroacetophenone
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 019457
- Product name
- 2,4-Dichloro-5-fluoroacetophenone
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2,4-Dichloro-5-fluoroacetophenone Chemical Properties,Usage,Production
Application
2,4-Dichloro-5-fluoroacetophenone is an important chemical raw material used as a pharmaceutical intermediate. It is a major intermediate for the third-generation broad-spectrum and highly effective quinolone antibacterial agents ciprofloxacin and enrofloxacin.
Chemical Properties
white to light yellow cryst. low melting solid
Synthesis
1435-48-9
75-36-5
704-10-9
In a 1000 mL four-necked flask, 15 g (0.091 mol) of 2,4-dichlorofluorobenzene was added and cooled to 20°C. The solution was then purified with aluminum chloride. Subsequently, 200.2 g (1.5 mol) of aluminum chloride was added, the temperature was maintained between 20-30°C, and 78.5 g (1.0 mol) of acetyl chloride was slowly added dropwise, with the dropwise process being controlled to be completed in 2 to 3 hours. The reaction mixture was gradually heated to 40°C and maintained for 30 minutes, then slowly warmed to 70°C and maintained for 1~2 hours. Then, the heating was continued slowly to 110°C and the reaction was carried out at 110±2°C for 3~4 hours. After the reaction was completed, it was cooled to room temperature, 500 g of 5% hydrochloric acid solution was added and hydrolyzed at 80~90°C for 2~3 hours. After the hydrolysis product was washed to neutral, the organic phase was separated and purified by secondary distillation and recrystallization to obtain 168 g of 2',4'-dichloro-5'-fluoroacetophenone with a purity of 99.8% and a yield of 89.3%.
References
[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0020; 0082-0083
[2] Tetrahedron Letters, 2009, vol. 50, # 21, p. 2525 - 2528
[3] Patent: WO2010/58421, 2010, A2. Location in patent: Page/Page column 20-21
[4] Patent: US6967205, 2005, B1. Location in patent: Page/Page column 25-26
2,4-Dichloro-5-fluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dichloro-5-fluoroacetophenone Suppliers
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- --
- Fax
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- brian@chordip.com
- Country
- Jordan
- ProdList
- 704
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View Lastest Price from 2,4-Dichloro-5-fluoroacetophenone manufacturers
- Product
- 2,4-Dichloro-5-fluoroacetophenone 704-10-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 2,4-Dichloro-5-fluoroacetophenone 704-10-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-27
- Product
- 1-(2,4-Dichloro-5-fluorophenyl)ethanone 704-10-9
- Price
- US $9.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-23