5-Amino-4,6-dichloropyrimidine

Product Name: 5-Amino-4,6-dichloropyrimidine
CAS No.: 5413-85-4
Chemical Name: 5-Amino-4,6-dichloropyrimidine
Synonyms: 4,6-DICHLOROPYRIMIDIN-5-AMINE;NSC 7851;5-AMino-4;AKOS 91433;TIMTEC-BB SBB003920;5-Amino-4,6-dichloro;4,6-dichloro-5-pyrimidinamin;4,6-DICHLORO-5-PYRIMIDINAMINE;5-AMINO-4,6-DICHLOROPYRIMIDINE;5-AMINO-4,6-DICHLOROPYFIMIDINE
CBNumber: CB3221794
Molecular Formula: C4H3Cl2N3
Formula Weight: 163.99
MOL File: 5413-85-4.mol

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5-Amino-4,6-dichloropyrimidine Property

Melting point:: 145-148 °C (lit.)
Boiling point:: 270.44°C (rough estimate)
Density: 1.6662 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: 2-8°C
solubility: slightly soluble
pka: -3.01±0.26(Predicted)
form: Crystals or Powder
color: Yellow-brown
Water Solubility: slightly soluble
Sensitive: Moisture Sensitive
BRN: 126885
InChIKey: NIGDWBHWHVHOAD-UHFFFAOYSA-N
CAS DataBase Reference: 5413-85-4(CAS DataBase Reference)
NIST Chemistry Reference: 5-Amino-4,6-dichloropyrimidine(5413-85-4)
EPA Substance Registry System: 5-Pyrimidinamine, 4,6-dichloro- (5413-85-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
F: 10-21
TSCA: Yes
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 217735
Product name: 5-Amino-4,6-dichloropyrimidine
Purity: 97%
Packaging: 5g
Price: $50.96
Updated: 2025/07/31

TCI Chemical

Product number: A1395
Product name: 5-Amino-4,6-dichloropyrimidine
Purity: >98.0%(N)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: A1395
Product name: 5-Amino-4,6-dichloropyrimidine
Purity: >98.0%(N)
Packaging: 5g
Price: $39
Updated: 2025/07/31

Sigma-Aldrich

Product number: 217735
Product name: 5-Amino-4,6-dichloropyrimidine
Purity: 97%
Packaging: 25g
Price: $312
Updated: 2025/07/31

TCI Chemical

Product number: A1395
Product name: 5-Amino-4,6-dichloropyrimidine
Purity: >98.0%(N)
Packaging: 25g
Price: $50
Updated: 2025/07/31

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5-Amino-4,6-dichloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Yellowish-brown crystals or powder

Uses

An intermediate in the production of many biological inhibitors.

Uses

5-Amino-4,6-dichloropyrimidine was used in the synthesis of:

oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides
conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane nucleosides
N(7)-substituted purines
chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine
9-alkyl-6-substituted-purine analogs, potent anticonvulsant agents
pyrimido-oxazepines in a three-step process with microwave heating at 150°C

Synthesis

4316-93-2

5413-85-4

GENERAL METHODS: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the reaction solution was filtered through a diatomaceous earth filter to remove the Pd/C catalyst, and the filtrate was concentrated to give the target product 4,6-dichloro-5-aminopyrimidine [46].

References

[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 1, p. 54 - 58
[2] Tetrahedron, 1988, vol. 44, # 19, p. 6207 - 6216
[3] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 212 - 228
[4] Synlett, 2010, # 20, p. 3019 - 3022
[5] Synthetic Communications, 2007, vol. 37, # 16, p. 2777 - 2786

5-Amino-4,6-dichloropyrimidine Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Hexane 4,6-Dihydroxypyrimidine N,N-Diisopropylethylamine Trifluoroacetic acid Phosphorus oxitrichloride Ethyl acetate Nitric acid

Preparation Products

4,5-Diaminopyrimidine

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5-Amino-4,6-dichloropyrimidine Suppliers

Americas 1 Belgium 1 Canada 3 China 312 Europe 3 Germany 4 India 14 Japan 3 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 19 United States 50 Global 415

Liyang Kunlu biological technology co.,ltd

Tel: 0519-87310015 13813530041
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Suzhou Tianhong Medicine Chemical Technology Co.,Ltd.

Tel: 18949937116
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SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

Tel: 400-6106006
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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ShangHai DEMO Chemical Co.,Ltd

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View Lastest Price from 5-Amino-4,6-dichloropyrimidine manufacturers

Dideu Industries Group Limited

Product: 5-Amino-4,6-dichloropyrimidine 5413-85-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Amino-4,6-dichloropyrimidine 5413-85-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Amino-4,6-dichloropyrimidine 5413-85-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

5413-85-4, 5-Amino-4,6-dichloropyrimidineRelated Search:

EC 2.6.1.2 Glucosamine 4,6-Diaminopyrimidine Glycine 6-Aminocaproic acid Dichloroethane 3-Aminophenol ALTRENOGEST 4,6-Dichloro-5-fluoropyrimidine 4,6-Dichloropyrimidine Aminopyrine Acetaminophen Tris(hydroxymethyl)aminomethane 2-AMINO-4,6-DICHLOROPYRIMIDINE 95+%,2-AMINO-4,6-DICHLOROPYRIMIDINE 97+%,2-AMINO-4,6-DICHLOROPYRIMIDINE, TECH. 95%,2-AMINO-4,6-DICHLOROPYRIMIDINE 2,5-Diamino-4,6-dichloropyrimidine 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 5-Amino-4,6-dichloro-2-methylpyrimidine N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

4,6-DICHLORO-5-PYRIMIDINAMINE

4,6-DICHLOROPYRIMIDIN-5-AMINE

4,6-DICHLOROPYRIMIDIN-5-YLAMINE

AKOS 91433

5-PYRIMIDINAMINE, 4,6-DICHLORO-

4,6-Dichloro-5-aminopyrimidine

4,6-dichloro-5-pyrimidinamin

5-AMINO-4,6-DICHLOROPYFIMIDINE

5-AMINO-4,6-DICHLOROPYRIMIDINE

Pyrimidine, 5-amino-4,6-dichloro-

TIMTEC-BB SBB003920

5-Amino-4,6-dichloro

5-AMINO-4,6-DICHLORPYRIMIDIN 97%

5-Amino-4,6-dichloropyrimidine, 98+%

5-amine-4,6-dichloropyrimidine

5-Amino-4,6-dichloropyrimidine,97%

5-AMino-4

5-AMino-4,6-dichloropyriMidine, 97% 1GR

NSC 7851

5-AMino-4,6-dichloripyriMidine

5- aMino-4,6-two chloropyriMidine

4,6-Dichloropyrimidin-5-amine, 5-Amino-4,6-dichloro-1,3-diazine

5-Amino-4,6-dichloropyrimidine ISO 9001：2015 REACH

5-Amino-4,6-dichloropyrimidine, 96%

5413-85-4

1234-23-6

C4H23C12N3

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

Building Blocks

Bases & Related Reagents

Heterocycles

Nucleotides

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Aromatics

Heterocyclic Compounds

Heterocycle-Pyrimidine series

Pyridines, Pyrimidines, Purines and Pteredines

Pyrimidine

Pyrimidines

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