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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Product Name
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
CAS No.
171887-03-9
Chemical Name
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Synonyms
N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide;2-Amino-4,6-dichloro-5-pyrimidinyl formamide;JACS-171887-03-9;2-Amino-4,6-dichloro-5-;N-(2-Amino-4,6-Dichloro-5-Pyri;2,5-Diamino-4,6-DichloroformamidoHcl;2-amino-4,6-dichloro-5-formamidopyrimidin;2-Amino-4,6-dichloro-5-formamidopyrimidine;2-Amino-4,6-dichloro-5-carbamoylpyrimidine;2-Amino-4,6-dichloro-5-formanido pyrimidine
CBNumber
CB5547319
Molecular Formula
C5H4Cl2N4O
Formula Weight
207.02
MOL File
171887-03-9.mol
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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Property

Melting point:
>251°C (dec.)
Boiling point:
554.8±60.0 °C(Predicted)
Density 
1.742±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO, Methanol
form 
Solid
pka
10.90±0.70(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C5H4Cl2N4O/c6-3-2(9-1-12)4(7)11-5(8)10-3/h1H,(H,9,12)(H2,8,10,11)
InChIKey
XYWHZUCZNRMJGO-UHFFFAOYSA-N
SMILES
C(NC1=C(Cl)N=C(N)N=C1Cl)=O
CAS DataBase Reference
171887-03-9(CAS DataBase Reference)
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Safety

HS Code 
2933.59.9500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2146
Product name
2-Amino-4,6-dichloro-5-formamidopyrimidine
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
A2146
Product name
2-Amino-4,6-dichloro-5-formamidopyrimidine
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$112
Updated
2025/07/31
TRC
Product number
A604735
Product name
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Packaging
25g
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA11724
Product name
N-(2-Amino-4,6-dichloro-5-pyrimdinyl)formamide
Packaging
250g
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
073126
Product name
N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide
Purity
95+%
Packaging
100g
Price
$150
Updated
2021/12/16
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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Uses

Prasugrel intermediate

Uses

Abacavir intermediate. A purine derivative

Synthesis

64-18-6

55583-59-0

171887-03-9

1. 2,5-diamino-4,6-dichloropyrimidine (0.01 mol, 2.0 g) was mixed with water (0.25 mol, 4.55 mL) at room temperature and stirred. 2. 98% formic acid (0.4 mol, 18.27 g, 14.97 mL) was slowly added to the reaction system. 3. The reaction mixture was heated to 50-55 °C and maintained at this temperature for 3 hours. 4. Upon completion of the reaction, toluene (0.38 mol, 34.6 g, 40 mL) was added to the reaction system at 50 °C for azeotropic distillation. This process was repeated once, using a total of 80 mL of toluene to ensure adequate distillation. 5. After the reaction mixture was cooled, the solid product was collected by filtration and washed with cold water. 6. The washed product was dried under vacuum at 60°C. 7. 7. 2-amino-4,6-dichloro-5-formamidopyrimidine (0.01 mol, 2.0 g) was finally obtained in about 90% yield.

References

[1] Patent: EP1188750, 2002, A1. Location in patent: Page 5

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Preparation Products And Raw materials

Raw materials

Barbituric acid Heptane Aluminium-nickel Ammonium hydroxide Ethanol Sodium sulfate Toluene Formic acid Phosphorus oxitrichloride Diethyl ether Nitric acid Sodium hydroxide N,N-Diethylaniline

Preparation Products

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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Suppliers

Americas 1 Canada 2 China 247 Europe 4 Germany 4 India 70 Japan 1 Russia 1 Slovakia 1 United Kingdom 8 United States 28 Global 367
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Shaanxi Linbang Industrial Co., Ltd
Tel
17709134430
Email
2379795542@qq.com
Country
China
ProdList
4822
Advantage
58
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.
Tel
027-83855312 17771813295 13377865312
Email
2668571332@qq.com
Country
China
ProdList
1000
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58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
918
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
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57
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Suzhou Kaiyuan Minsheng Sci&Tech Corp. Ltd.
Tel
0512-62889106 13814821352;
Fax
0512-62889106
Email
business@minshengpharm.com
Country
China
ProdList
11
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66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
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66
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View Lastest Price from N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide 171887-03-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-11
Shaanxi Dideu Medichem Co. Ltd
Product
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide 171887-03-9
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-05-19
Shaanxi Dideu Medichem Co. Ltd
Product
N-(2-AMINO-4,6-DICHLORO-5-PYRIMIDINYL)FORMAMIDE
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500 tons
Release date
2020-05-20

171887-03-9, N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamideRelated Search:

ALTRENOGEST 4,6-Dichloropyrimidine 2-Amino-4,6-dichloropyrimidine p-Aminobenzamide Benzamide Dichloroacetic acid 6-Aminocaproic acid Formamide Glycine Chlorantraniliprole 2-Aminopyrimidine N,N-Dimethylformamide 5-Cyanophthalide 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride 1,2,3-Triacetyl-5-deoxy-D-ribose Tris(hydroxymethyl)aminomethane 5-Amino-4,6-dichloropyrimidine 2,5-Diamino-4,6-dichloropyrimidine

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  • N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
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  • ForMaMide,N-(2-aMino-4,6-dichloro-5-pyriMidinyl)-
  • JACS-171887-03-9
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  • 2-Amino-4,6-dichloro-5-formamidopyrimidine &gt
  • N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide ISO 9001：2015 REACH
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  • 2-amino-4,6-dichloro-5-formamidopyrimidin
  • N-(2-Amino-4,6-Dichloro- Pyrimidin-5-yl) Formamide(FADCP)
  • 2-Amino-4,6-dichloro-5-carbamoylpyrimidine
  • 171887-03-9
  • Heterocycle-Pyrimidine series
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Heterocyclic Compounds
  • Heterocycle
  • 3