2,5-Diamino-4,6-dichloropyrimidine

Product Name: 2,5-Diamino-4,6-dichloropyrimidine
CAS No.: 55583-59-0
Chemical Name: 2,5-Diamino-4,6-dichloropyrimidine
Synonyms: AKOS 90003;2,5-Diamino-4,6-Dichloropyrimi;dichloropyriMidine-2,5-diaMine;4,6-Dichlorpyrimidin-2,5-diamin;4,6-Dichlorpyrimidine-2,5-diamine;4,6-DICHLOROPYRIMIDINE-2,5-DIAMINE;2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE;4,6-dichloro-2,5-diaminopyrimidine;2,5-PYRIMIDINEDIAMINE, 4,6-DICHLORO;4,6-Dichloro-2,5-diamine pyrimidine
CBNumber: CB1197259
Molecular Formula: C4H4Cl2N4
Formula Weight: 179.01
MOL File: 55583-59-0.mol

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2,5-Diamino-4,6-dichloropyrimidine Property

Melting point:: 188-191 °C (decomp)
Boiling point:: 395.8±52.0 °C(Predicted)
Density: 1.715±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol (Slightly), Water (Slightly)
form: Solid
pka: 1.08±0.10(Predicted)
color: Pale Red to Light Red
InChI: InChI=1S/C4H4Cl2N4/c5-2-1(7)3(6)10-4(8)9-2/h7H2,(H2,8,9,10)
InChIKey: ZXWGHENZKVQKPX-UHFFFAOYSA-N
SMILES: C1(N)=NC(Cl)=C(N)C(Cl)=N1
CAS DataBase Reference: 55583-59-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4231
Product name: 2,5-Diamino-4,6-dichloropyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: D4231
Product name: 2,5-Diamino-4,6-dichloropyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: D415110
Product name: 2,5-Diamino-4,6-dichloropyrimidine
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Usbiological

Product number: 295994
Product name: 2,5-Diamino-4,6-dichloropyrimidine
Packaging: 10g
Price: $531
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD16293
Product name: 2,5-Diamino-4,6-dichloropyrimidine
Packaging: 100g
Price: $400
Updated: 2021/12/16

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2,5-Diamino-4,6-dichloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

2,5-Diamino-4,6-dichloropyrimidine is a useful reagent for the preparation of Abacavir impurities, carbocyclic and hexenopyranosy nucleosides.

Uses

2,5-Diamino-4,6-dichloropyrimidine is used as building block in chemical synthesis.

Synthesis

56830-58-1

55583-59-0

General procedure for the synthesis of 2,5-diamino-4,6-dihydroxypyrimidine hydrochloride from 2,5-diamino-4,6-dichloropyrimidine hydrochloride: 2,5-diamino-4,6-dihydroxypyrimidine hydrochloride (0.14 mol, 25 g) was placed in a dry reactor, and dry 1,2,3-trichloropropane (51.96 mL) was added and stirred. Subsequently, tetramethylammonium chloride (0.29 mol, 31.25 g) and phosphorous trichloride (0.54-0.81 mol, 83.28-124.9 g, 50.6-75.9 mL) were added sequentially. The reaction mixture was heated to reflux (about 115°C) and maintained for 24 hours. Upon completion of the reaction, it was cooled to below 50°C and ice water (24.44 mol, 440.44 g) was added slowly, keeping the temperature below 55°C. The pH was adjusted to 6.5-7.0 with 50% sodium hydroxide solution (3.12 mol, 124.92 g, 163.3 mL), keeping the temperature below 55°C, and stirring was continued for 30 minutes. Subsequently, the reaction mixture was stirred at 50-60°C and tetrahydrofuran (3.7 mol, 267.0 g, 300 mL) was added. Insoluble material was removed by diatomaceous earth filtration and the filter cake was washed with ethyl acetate (20.5 mol, 1806.58 g, 2002.86 mL). The organic phases (tetrahydrofuran and ethyl acetate) were combined, washed three times with water (5.57 mol, 100.32 g, 100.32 L), dried with sodium bicarbonate and filtered. Ethyl acetate was removed by vacuum distillation, hexane (0.77 mol, 66.14 g, 100.36 mL) was added to the residue, cooled to below 10°C, filtered, and the resulting solid was dried in vacuo at 50°C to afford the title product, 2,5-diamino-4,6-dichloropyrimidine (0.09 mol, 15.71 g), as a slightly brownish solid in about 65% yield .

References

[1] Patent: EP1188750, 2002, A1. Location in patent: Page 5
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 2, p. 655 - 668
[3] Patent: US2012/46278, 2012, A1. Location in patent: Page/Page column 75
[4] Patent: US2013/190297, 2013, A1. Location in patent: Paragraph 1123
[5] Patent: US2014/88088, 2014, A1. Location in patent: Paragraph 1138

2,5-Diamino-4,6-dichloropyrimidine Preparation Products And Raw materials

Raw materials

Sodium dithionite Acetonitrile Benzyltriethylammonium chloride Ethanol 2-AMINODIETHYLMALONATE Sodium chloride Sodium Phosphorus oxitrichloride 2-Amino-4,6-dihydroxypyrimidine Sodium nitrite Phosphorus pentachloride Guanidine hydrochloride Ethyl acetate Hydrochloric acid Triethylmethylammonium chloride Sodium hydroxide Magnesium sulfate Ammonia

Preparation Products

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2,5-Diamino-4,6-dichloropyrimidine Suppliers

Americas 1 Canada 2 China 231 Europe 4 Germany 2 India 11 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 10 United States 31 Global 295

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View Lastest Price from 2,5-Diamino-4,6-dichloropyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,5-Diamino-4,6-dichloropyrimidine 55583-59-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,5-Diamino-4,6-dichloropyrimidine 55583-59-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2,5-Diamino-4,6-dichloropyrimidine 55583-59-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

55583-59-0, 2,5-Diamino-4,6-dichloropyrimidineRelated Search:

N,N-Dimethyl-1,4-phenylenediamine 4,6-Diaminopyrimidine 2,5-Dichloropyrimidine 1,3-Diaminoguanidine monohydrochloride 2,3-DIAMINOTOLUENE Dichlorodimethylsilane 2-Amino-4,6-dichloropyrimidine Diisopropylammonium dichloroacetate 4,6-Dichloropyrimidine Iminodiacetonitrile Iminodiacetic acid HYDRAZINE 4,4'-Methylenedianiline 2,5-Diamino-4,6-dichloropyrimidine hydrochloride N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride 2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE,97% 2,5-Diamino-4,6-dichloropyrimidine

AKOS 90003

2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE 98+%

4,6-DICHLOROPYRIMIDINE-2,5-DIAMINE

2,5-PYRIMIDINEDIAMINE, 4,6-DICHLORO

2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE

2,5-Diamino-4,6-Dichloropyrimi

4,6-Dichlorpyrimidine-2,5-diamine

(2-amino-4,6-dichloro-pyrimidin-5-yl)amine

2,5-Diamino-4,6-dichloropyrimidine, 2,5-Diamino-4,6-dichloro-1,3-diazine

dichloropyriMidine-2,5-diaMine

2,5-Diamino-4,6-dichloropyrimidine&gt

2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE,CAS:55583-59-0

4,6-Dichlorpyrimidin-2,5-diamin

4,6-dichloro-2,5-diaminopyrimidine

4,6-Dichloro-2,5-diamine pyrimidine

55583-59-0

55-52-4

5583-59-0

C4H4N4Cl2

C4H4Cl2N4

Heterocycle-Pyrimidine series

Pyrimidines

various pyrimidines

APIs & Intermediate

Pyrimidine