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Diisopropylammonium dichloroacetate

Product Name
Diisopropylammonium dichloroacetate
CAS No.
660-27-5
Chemical Name
Diisopropylammonium dichloroacetate
Synonyms
N-isopropylpropan-2-amine;Diisopropylammonium;Dedyl;Dapocel;β-Anoxin;Oxypangam;N-propan-2-ylpropan-2-amine;diisopropylaMini dichlorocacetas;diisopropylammonium dichloroacetate;Diisopropylaminedichloroacetate,95%
CBNumber
CB22130466
Molecular Formula
C8H17Cl2NO2
Formula Weight
230.13208
MOL File
660-27-5.mol
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Diisopropylammonium dichloroacetate Property

Melting point:
119-121°
RTECS 
AG6475000
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
color 
White
Merck 
14,3197
Stability:
Hygroscopic
InChI
InChI=1S/C6H15N.C2H2Cl2O2/c1-5(2)7-6(3)4;3-1(4)2(5)6/h5-7H,1-4H3;1H,(H,5,6)
InChIKey
ILKBHIBYKSHTKQ-UHFFFAOYSA-N
SMILES
C(O)(=O)C(Cl)Cl.CC(NC(C)C)C
CAS DataBase Reference
660-27-5
EPA Substance Registry System
Acetic acid, dichloro-, compd. with N-(1-methylethyl)-2-propanamine (1:1) (660-27-5)
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Safety

TSCA 
Yes
HS Code 
2921199990
Toxicity
LD50 orally in mice: 1700 mg/kg (Kraushaar)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5074
Product name
Diisopropylamine Dichloroacetate
Purity
>98.0%(T)
Packaging
1g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
D5074
Product name
Diisopropylamine Dichloroacetate
Purity
>98.0%(T)
Packaging
5g
Price
$55
Updated
2024/03/01
Alfa Aesar
Product number
H61341
Product name
Diisopropylamine dichloroacetate, 95%
Packaging
1g
Price
$116
Updated
2023/06/20
Alfa Aesar
Product number
H61341
Product name
Diisopropylamine dichloroacetate, 95%
Packaging
5g
Price
$409
Updated
2021/12/16
Alfa Aesar
Product number
H61341
Product name
Diisopropylamine dichloroacetate, 95%
Packaging
250mg
Price
$40.2
Updated
2023/06/20
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Diisopropylammonium dichloroacetate Chemical Properties,Usage,Production

Description

Diisopropylammonium dichloroacetate is a hepatoprotective drug that improves the energy metabolism of hepatocytes, promotes the regeneration of injured hepatocytes, increases the rate of tissue cell respiration and oxygen respiration, and reduces the accumulation of fat in the liver. It is mainly used clinically for the treatment of fatty liver, intrahepatic cholestasis, and general liver dysfunction. It is also used in the treatment of acute and chronic hepatitis, hepatomegaly, and early cirrhosis.

Chemical Properties

White or off-white loose mass or powder, slightly bitter, easily soluble in water, ethanol or chloroform, slightly soluble in ether.

History

In the 1950s, the compound diisopropylammonium dichloroacetate (DIPA) was used in the synthesis of methylated derivatives of a purportedly naturally occurring B vitamin (pangamic acid; dgluconodimethylaminoacetate). Anecdotal clinical reports appeared claimingefficacy in various metabolic and cardiovascular disorders from pharmaceuticalmixtures of pangamic acid and DIPA. In 1970,DCA was identified as themetabolically active moiety of DIPA(Stacpoole & Felts,1970) and it has beenused thereafter almost exclusively as the sodium salt.

Uses

Diisopropylammonium dichloroacetate (DIPA) is known to produce a significant and prolonged hypoglycemic effect in alloxan-diabetic but not in normal rats.
Diisopropylamine 2,2-Dichloroacetate is used in the treatment of antituberculosis drugs-induced liver injury.

Definition

ChEBI: Diisopropylamine dichloroacetate is an organohalogen compound and a carboxylic acid.

Synthesis

Diisopropylammonium dichloroacetate is prepared by the reaction of dichloro-acetic acid and diisopropylamine. The steps are as follows:
1 volume of acetone is mixed with 1.5 volumes of cyclohexane to obtain a mixed solvent; Add 1 mol of diisopropylamine (101.19g, C6H15N, Mr=101.19) into 150ml of mixed solvent, stir evenly, and heat the liquid material to 50°C; slowly add 1mol of dichloroacetic acid (128.94g, C2H2Cl2O2, Mr=128.94) dropwise to the liquid material obtained in step (at a speed of about 10g/min) under heat preservation and stirring conditions,After the feeding is complete, keep warm and continue to stir for 3 hours, then naturally cool to 4-8°C, and then stand at this temperature for 10 hours; Filter the material obtained in step, separate the mother liquor, collect white crystals, and dry at 70° C. to obtain 216.8 g of the diisopropylamine dichloroacetate (C8H17Cl2NO2, Mr=230.13), with a molar yield of 94.2%.

Mode of action

The mechanism of action of diisopropyl dichloroacetate is to enhance the fluidity of hepatocyte membranes by promoting sequential methylation of membrane phospholipids, to increase the activity of Na+-K+-ATPase, which is the main driving force of bile secretion and flow; to promote the functional repair of damaged hepatocytes, to improve the respiratory function and oxygen utilization of tissue cells, to increase the metabolic activity of fatty acids, to accelerate the oxidation of fatty acids, and to create conditions for the recovery of liver function.

Diisopropylammonium dichloroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Diisopropylammonium dichloroacetate Suppliers

Hubei Deli Pharmaceutical Technology Co., Ltd
Tel
13372285931
Email
52519240@qq.com
Country
China
ProdList
95
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58
Jinan Londi Medical Technology Co., LTD
Tel
0531-88996911 15628983711
Fax
0531-88996911
Email
3305202763@qq.com
Country
China
ProdList
125
Advantage
58
shandong XuanHong Pharmaceutical Technology Co.,Ltd
Tel
0531-88801869 15562622698
Fax
0531-88801867
Email
sciencechem@163.com
Country
China
ProdList
276
Advantage
55
Jinan Shengqi Pharmaceutical Co., Ltd
Tel
0531-88892685 18660160628
Email
2153390475@qq.com
Country
China
ProdList
191
Advantage
58
Wuhan Yida Pharmaceutical Co., Ltd
Tel
+86-13401188533 +86-13476102740
Email
3451936732@qq.com
Country
China
ProdList
26
Advantage
58
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
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View Lastest Price from Diisopropylammonium dichloroacetate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Diisopropylammonium dichloroacetate 660-27-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-08-31
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Diisopropylammonium dichloroacetate 660-27-5
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-03-01
shandong perfect biotechnology co.ltd
Product
diisopropylammonium dichloroacetate 660-27-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99% HPLC
Supply Ability
5 TON
Release date
2023-07-06

660-27-5, Diisopropylammonium dichloroacetateRelated Search:


  • Dapocel
  • Dedyl
  • Oxypangam
  • β-Anoxin
  • N-propan-2-ylpropan-2-amine
  • Diisopropylammonium
  • diisopropylammonium dichloroacetate
  • diisopropylaMini dichlorocacetas
  • bis(propan-2-yl)aMino 2,2-dichloroacetate
  • Diisopropylamine 2,2-dichloroacetate
  • Diisopropylamine dichloroacetate 97%
  • N-isopropylpropan-2-amine
  • Diisopropylaminedichloroacetate,95%
  • Diisopropylammonium dichloroacetate USP/EP/BP
  • 660-27-5
  • Liver Disease Series