4,6-Dichloro-5-fluoropyrimidine

Product Name: 4,6-Dichloro-5-fluoropyrimidine
CAS No.: 213265-83-9
Chemical Name: 4,6-Dichloro-5-fluoropyrimidine
Synonyms: 6-Dichloro-5-fluoropyriMidine;4,6-Dichloro-5-Fluoro Pyridine;4,6-DICHLORO-5-FLUORO-PYRIMIDINE;4,6-Dichloro-5-fluoro-1,3-diazine;4,6-Dichloro-5-fluoropyriMidinene;Pyrimidine, 4,6-dichloro-5-fluoro-;4,6-Dichloro-5-fluoropyrimidine,98%;4,6-Dichloro-5-fluoropyrimidine ISO 9001：2015 REACH
CBNumber: CB8475240
Molecular Formula: C4HCl2FN2
Formula Weight: 166.97
MOL File: 213265-83-9.mol

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4,6-Dichloro-5-fluoropyrimidine Property

Boiling point:: 50-60℃/14mm
Density: 1.605±0.06 g/cm3(Predicted)
Flash point:: 91°(196°F)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO, Methanol (Slightly)
form: Liquid
pka: -5.42±0.26(Predicted)
color: Colourless
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C4HCl2FN2/c5-3-2(7)4(6)9-1-8-3/h1H
InChIKey: DGMIGAHDDPJOPN-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(F)C(Cl)=N1

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Safety

Safety Statements: 24/25
RIDADR: UN3265
HazardClass: IRRITANT
HazardClass: 8
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D437193
Product name: 4,6-Dichloro-5-fluoropyrimidine
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-87
Product name: 4,6-Dichloro-5-fluoropyrimidine
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 059861
Product name: 4,6-Dichloro-5-fluoropyrimidine
Purity: >96%
Packaging: 5g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD11921
Product name: 4,6-Dichloro-5-fluoropyrimidine
Packaging: 1g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC51025
Product name: 4,6-Dichloro-5-fluoropyrimidine
Packaging: 1g
Price: $70
Updated: 2021/12/16

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4,6-Dichloro-5-fluoropyrimidine Chemical Properties,Usage,Production

Uses

4,6-Dichloro-5-Fluoropyrimidine is an useful intermediate for pharmaceuticals.

Synthesis

106615-61-6

213265-83-9

General procedure for the synthesis of 4,6-dichloro-5-fluoropyrimidine from 5-fluoro-4,6-dihydroxypyrimidine (Method B): phosphoryl chloride (0.593 L, 6.376 mol) was slowly added to a 2 L three-necked round-bottomed flask containing 5-fluoropyrimidine-4,6-diol (276.459 g, 2.125 mol) to form a slurry at room temperature. N,N-dimethylaniline (81 mL, 0.638 mol) was slowly added to this slurry through the addition funnel and the reaction was exothermic. The reaction mixture was continued to be stirred at 110°C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into a 2 L mixture consisting of brine and ice under stirring. The aqueous layer (showing red color) was extracted with dichloromethane (2 x 2 L). The organic layers were combined and washed sequentially with cold 6 N hydrochloric acid (2 × 1 L, showing honey brown color) and saturated sodium bicarbonate solution (1 L). The organic layer was dried with anhydrous sodium sulfate, filtered through glass fiber paper under vacuum, and concentrated under reduced pressure (without heating) to afford 4,6-dichloro-5-fluoropyrimidine (CAS No. 213265-83-9, 347.9 g, 2.084 mol, 98% yield) as an amber colored oil. Nuclear magnetic resonance (NMR) analysis showed traces of dichloromethane in the product. 4,6-Dichloro-5-fluoropyrimidine (420 g, 2.515 mol) was subjected to vacuum distillation, and the fraction with a boiling point of 35°C (pressure 1 torr) was collected to give a colorless oily substance (332.574 g, 1.992 mol, 79% yield). The product solidified at -78°C and remelted to liquid at room temperature. Distillation conditions: oil bath temperature 100°C; product boiling point 35°C; pressure 1 Torr. 1H NMR (400 MHz, DMSO-d6) δ 8.8 (s, 1H).

References

[1] Patent: WO2012/40279, 2012, A1. Location in patent: Page/Page column 86
[2] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 11
[3] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 11
[4] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 12
[5] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 10

4,6-Dichloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-Dichloro-5-fluoropyrimidine Suppliers

China 204 India 2 United Kingdom 6 United States 21 Global 233

Shanghai Arbor Chemical Co., Ltd.

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View Lastest Price from 4,6-Dichloro-5-fluoropyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4,6-Dichloro-5-fluoropyrimidine 213265-83-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 4,6-Dichloro-5-fluoropyrimidine 213265-83-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Henan Fengda Chemical Co., Ltd

Product: 4,6-Dichloro-5-fluoropyrimidine 213265-83-9
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

213265-83-9, 4,6-Dichloro-5-fluoropyrimidineRelated Search:

5-Fluoropyrimidine 2-Chloro-5-fluoropyrimidine 5-Fluorouracil 4,6-Dichloropyrimidine Fluorocytosine 4,6-Dichloro-5-nitropyrimidine 5-Bromo-4,6-dichloropyrimidine 5-Amino-4,6-dichloropyrimidine 4,6-Dichloro-2-methylpyrimidine 2-Fluoro-3,5-dichloropyridine 3,5-DICHLORO-4-FLUOROPYRIDINE 2,4-Dichloro-5-fluoropyrimidine Dichlorofluoroethane Pyrimidine, 4-chloro-5-fluoro- (9CI) 4,6-Dichloro-2-ethyl-5-fluoropyrimidine 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE 4,6-Dichloro-5-fluoropyrimidine

4,6-DICHLORO-5-FLUORO-PYRIMIDINE

4,6-Dichloro-5-fluoropyriMidinene

4,6-Dichloro-5-fluoro-1,3-diazine

4,6-Dichloro-5-Fluoro Pyridine

6-Dichloro-5-fluoropyriMidine

Pyrimidine, 4,6-dichloro-5-fluoro-

4,6-Dichloro-5-fluoropyrimidine,98%

4,6-Dichloro-5-fluoropyrimidine ISO 9001：2015 REACH

213265-83-9

Fluorine series

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